The Ultimate Human with Gary Brecka - 182. Brigham Buhler: The Peptide Safety Data Reveals 75,000+ Patients With Zero Adverse Events

Starting point is 00:00:00 The FDA makes this decision in a vacuum to essentially ban and shut down accessibility to dozens of peptides. And not because they were harming people, but for what they called a lack of safety data. Historically, the FDA has been controlled and met with the big pharmaceutical institutes. You can't assume that they have a fundamental understanding of peptides. You don't know what they've been told by chemical and farm industry. You're only as good as the intel you have. And if our intel's bad, we can't be shocked when we make bad decisions. Shouldn't we open lanes for people to make choices where the outcome is,

Starting point is 00:00:34 maybe this doesn't work but it's caused no harm? I believe that peptides, all of these things, are crucial pillars to driving healthspan, which indirectly drives lifespan. Some of the best modalities are the ones that harness the body's ability to do its job on its own. The thought that we could just bring that back and make it available en masse, to me, is really exciting. The safety profile is astronomically better than that of a drug, the risk profile is astronomically lower than that of a drug, and the efficacy is phenomenal. Can you talk a little bit about what you see

Starting point is 00:01:05 in this administration for maybe the lane widening and peptides? We're talking about human lives and the human experience. And if we can't keep people healthy and firing on all cylinders, the question is. Woo! Woo! Woo!

Starting point is 00:01:18 Woo! Woo! Woo! Woo! Woo! Woo! Ultimate human. Hey guys, welcome back to the ultimate human podcast. I'm your host, human biologist, Gary Breckow, where we go down the road of everything anti-aging

Starting point is 00:01:35 biohacking, longevity and everything in between. And today we're firing it up right from the White House. This is incredible. And I have been waiting to sit down with this man for actually more than a year ever since you gave me a shout out on Joe Rogan and I've been following your journey. Welcome to the podcast, Brigham Bueller.

Starting point is 00:01:53 Thank you for having me. Exciting times and what a crazy setup. Yeah, it's a crazy setup. I can't believe we're in the White House. I'm like, is anybody doing background checks on us? This is amazing. You and I have such similar missions, you know, the belief in the methylation pathways,

Starting point is 00:02:08 hormone balance, nutrient deficiencies. You know, we've been barking up the same tree for a long time. It's an absolute honor to sit down with your brother. You know, one of the things in this, you know, make America healthy again movement. You know, we've identified that there's a pandemic of chronic disease.

Starting point is 00:02:26 We've looked at some of the genesis of chronic disease, but I wanna move off of that a little bit and talk about the people that are already on this journey and what the possibility, because you and I both had, oh, I used to have functional medicine practices, you still do. We were heavily involved in peptides, you know, amino acid

Starting point is 00:02:46 sequences that are signaling molecules to the body that I am an enormous fan of because peptides are not drugs. They are analogs. They're usually sequences of amino acids. They usually cause the body to do something it would otherwise do on its own, secrete your own natural level of growth hormone, improve your levels of testosterone, help regulate cortisol, improve circulation, all kinds of things. And my favorite mantra for this category of biologics is that the body recognizes them, their amino acid sequences, They're metabolites. You can break them down. You can get rid of the waste.

Starting point is 00:03:27 And recently we saw the FDA come in and wipe out a whole class of these. And not because they were harming people, but for what they called a lack of safety data. Well, safety data could be, 20 million people have been prescribed these things without adverse events. I would say they're pretty safe.

Starting point is 00:03:48 We've never done a clinical trial on parachutes, but I wouldn't jump out of an airplane without one. At least not a placebo controlled randomized clinical trial, right? Who wants to be in group B? So can you talk a little bit about what you see in this administration for maybe the lane widening and peptides and what you've been talking about.

Starting point is 00:04:07 Absolutely, and thank you for having me and thank you for all you've been doing. I've been a fan from afar and listened to a lot of your talk track and I believe wholeheartedly in a lot of what you've been preaching for years and the proof's in the pudding. If you look at what you've been able to achieve with folks like Dana and the cascade effect of how that impacts so many lives. And so for me, I always bring

Starting point is 00:04:28 it back to like, we're talking about human lives and the human experience. And if we can't keep people healthy and firing on all cylinders, the question is why? And as we got into this study and what, and what this maha study shows, diet, lifestyle, nutrition, but a huge proponent is getting proactive, predictive, and personalized. And I believe that peptides and deep dive into biomarkers, all of these things are crucial pillars to driving health span, which indirectly drives lifespan. I think the American people voted for change. I think that people were excited to see Bobby, RFK, and Secretary Kennedy's push for better transparency and more trustworthy FDA.

Starting point is 00:05:14 And I can say early, I mean, we're what, 100 something days in, right before you and I started recording, I was just sharing with you, I had reached out to Secretary Kennedy and Stephanie, his chief of staff, and just said, hey, I would love the opportunity to just bend the ear of the FDA on these topics, peptides, the GLP-1, epockel, stem cells, and these regenerative treatment modalities, and just talk to them and try and understand. What's been your messaging to the FDA about that? I mean, where do you start with them?

Starting point is 00:05:47 Because you can't assume that they have a fundamental understanding of peptides. They may only hear, you don't know what they've been told by chemical pharma industry. They do. You could tell a lot of what they've been told was just talk track from big pharma, which is tough because even lobbying at the state level in Texas, when you lobby on food, you begin to realize, oh my God, everything that they're being told is just a lobbyist. They're parroting what the lobbyist said. So with peptides, their thing was, candidly in the meeting, one of the folks said there's

Starting point is 00:06:14 no clinical need for peptides. And I said, you do understand insulin is a peptide. The GLP-1s that are this blockbuster drug, you know, good, bad, or indifferent, like it's a tool in the tool belt. It's a peptide. These are signaling molecules that allow the body, like what you've talked about so much were deficient in the raw materials and elements essential to driving our health. And we're attempting to fix the food system, to fix and overhaul all these challenges that

Starting point is 00:06:41 Bonnie and folks like you have been ringing the bell on. But another integral part of that is providing a life raft, providing that optimization and providing accessibility to these modalities that we know are safe. Yeah. Like you were just saying, I mean, this is safe. This is available in nature. These are short chain amino acids. The safety profiles, astronomically better than that of a drug.

Starting point is 00:07:02 The risk profiles, astronaut, astronomically lower than that of a drug, the risk profiles astronomically lower than that of a drug, and the efficacy is phenomenal. Yes. So candidly, the feedback was more of them learning. It seemed like a lot of learning, a lot of note taking, a lot of listening, which I'm optimistic about. Yeah. And then we know, you know, personally,

Starting point is 00:07:20 from having interacted with Secretary Kennedy, he is a fan, he even tweeted about- Very pro-peptide, yeah. We is a fan, he even tweeted about, we are going to the war on peptides, stem cells, I think it was hyperbaric, all of this is over. I think he put psychedelics, yeah, yeah. There's a couple of categories in it, he goes, it's over. Which is great because the idea that we could open up

Starting point is 00:07:40 some of these lanes, right, for an informed consumer to say, yeah, you know what, I'm not just interested in being not diseased and not having diabetes or not having an autoimmune condition. I actually wanna thrive. I wanna think the best, feel the best, you know, sleep, you know, sleep deep.

Starting point is 00:07:58 I wanna have a strong libido. I wanna have a healthy response to exercise. Like I want it all. I mean, God put us here to thrive. And so if there are mechanisms that we can access like peptides under the guise of a physician, you know, supervised, that have these long safety records, I mean, I think Sir Morland, you know,

Starting point is 00:08:20 one of the first GHR pace growth hormone hormone releasing peptides, was first approved in like 1983, 1984. And so, FDA approved. And so, a lot of these have been around for decades. Well, look at testosterone. Yeah. Like, why are primary carriers in America terrified of testosterone? It goes back to a study from the 1930s that's been debunked. The dogma carries forward and people get analysis paralysis. And I think it's easy to historically prior to this new world where there's podcast and free speech and all of us able to think openly in the public eye and have, you know, lively discussions and deep dive into these things.

Starting point is 00:09:03 But it comes down a lot of times it's dogma and it's improper information. And I said this earlier, I don't want to, I don't want to, you know, villainize the FDA. You're only as good as the Intel you have. Right. And if our Intel's bad and our loopback feed is bad and the information we're getting is bad, then we can't be shocked when we make bad decisions because we're getting bad inputs. Historically, the FDA has been controlled and met with the big pharmaceutical institutes

Starting point is 00:09:34 because that was their model. And in this new world with RFK and this new administration, I think they're willing to sit down and meet with other folks like you and myself and other people. It is fascinating, man. I mean, the level of acceptance for my message, which when I began messaging 10 years ago, heavily called a charlatan, heavily called pseudoscience,

Starting point is 00:09:58 heavily attacked for not being a physician, which I've never held myself out as a physician. I'm not licensed to practice medicine. I have deep respect for the people that are. But the messaging about how nutrient deficient we've become and how amino acid and fatty acid deficient we've become and the consequences of that leading to things like this pandemic of chronic disease and that it's a lot easier to fix than we think it is.

Starting point is 00:10:22 It starts with some self responsibility. But I'm really excited about the future of peptides because in our practice, you know, we use BPC 157, TB 5000, thymus and alpha, which was also pulled. And you can get nutritional grade versions of these, but getting a good pharmaceutical compounded, highly sourced peptide where you know stability, sterility, potency, and you have some belief in the efficacy

Starting point is 00:10:54 because it was compounded effectively. The thought that we could just bring that back and make it available en masse to me is really exciting because we saw thousands of patients benefit from these. And I can tell you, I don't think, not I don't think, I do not recall a single adverse event. Same, same. Having a waste well now, I think we have over 75,000 patients

Starting point is 00:11:17 and we have not had any adverse events with any of the peptides. It's mind boggling. Distounding that level of safety and efficacy, man. And so the beauty is, like back to the FDA, I do think with bad information, you make bad decisions, but with good information, can we embolden and empower these folks

Starting point is 00:11:35 to make good decisions? And part of it's giving them the full story. You know, I just saw it with the GLP-1s. I don't know where your stance is. I personally feel like the GLP-1s are a great tool in the tool belt. I do too. I'm not anti-GLP-1s, I don't know where your stance is. I personally feel like the GLP-1s are a great tool in the tool belt. I do too. I'm not anti-GLP-1.

Starting point is 00:11:47 I mean, as long as, you know, patients understand, clients understand that we make GLP-1 in our gut. I mean, this is a hormone that we make and we make it in response to satiation, which is largely responsive to nutrient density. And so it should be a multifactorial approach, not continue to bathe your cellular biology in a toxic soup and take this injection,

Starting point is 00:12:07 but maybe stop bathing your cellular biology in this toxic soup. So let's get you on a whole food diet, nutrient-dense diet. Let's get movement and exercise, weight-bearing exercise as a part of your daily habits, and use the GLP-1s as a way to either accelerate that or to pull you back from the brink of disaster You know Smiling because literally I say all the time prescribing a GLP one without talking about diet lifestyle nutrition is

Starting point is 00:12:35 Literally like brushing your teeth while eating Oreos Yeah, it's pretty counterintuitive But as a tool in the tool belt for these obese and chronically, metabolically, disease-riddled people, putting a win on the board and creating momentum is crucial. And one of the things that happened right before Secretary Kennedy took power was the FDA redacted the exemption for compounding pharmacies. Literally weeks before he was sworn in, they removed the compounding pharmacies exemptions that allowed patients

Starting point is 00:13:05 accessibility to cost effective GLP ones. Right. So the average compounded price, I think in the U S is $150 in the average retail price through big pharma is $1250. So how many people are going to be left high and dry? And I say all that because it goes back to what we saw with peptides. What is happening is they're getting half stories, half truths. So Big Pharma, when they met with the FDA, told them we fixed the backlog. And so when

Starting point is 00:13:30 I met with the FDA, I said, well, where did they give you data? Did they give you it? Because we called 30,000 pharmacies a month for 12 months and less than 6% of prescriptions were available for Phil. So it's not, the backlog is still very much real. And what's happening because of media platforms like yourself and Bobby escalating, our secretary, Kenny, escalating these things is that voice is now resonating with the American people and they have line of sight into the truth.

Starting point is 00:13:58 And it makes it really hard for decisions to be made in a back room where nobody knows why or how. Right. Because there's enough data out there now we can do the digging. And so, you know, through these opportunities, I was able to provide the FDA with just information highlighting for them. Here are the court testimonies of these pharmaceutical companies themselves. We're in court. You actually pulled court testaments.

Starting point is 00:14:21 In the state of Texas under oath, they, we've never actually met the volumes that we told the FDA. We've never done it. In their own documents. And so I've provided all that over. And again, it's all it is, is through line of sight, we can give the FDA the ability to at least have line of sight into the truth, right? Whereas historically, because of the closed door,

Starting point is 00:14:45 you know, method of how they decide things, I don't think that was there. Yeah, and shouldn't we open lanes for people to make choices where the outcome is, maybe this doesn't work, but it's caused no harm? Because a lot of times, the choices that they make are chemical, synthetic, or pharmaceutical, and the outcome may be permanent harm, permanent dependency, tachyphylaxis, building a desensitization

Starting point is 00:15:10 response, something is materially going to change, you know, the trajectory of their life and, and yet they still had the downside that they didn't get what they were what they were after. I do like it's spot, because even with stem cells, that's one of the things. The whole stem cell market in the United States was hampered by the fear of the unknown

Starting point is 00:15:32 of what it could do. A potential theoretical framework that was never shown in actual utilization and practice. So one of the big fears is, historically, this is 20-year-old information, but the FDA was worried that stem cells would become something. And if they become something, then they could become a cancer cell. And if we treat people with these, are they going to exasperate cancer?

Starting point is 00:15:52 And all of a sudden we have cancer popping up. And the truth of the matter is now with research and time and practice, we realize these MSCs are signaling cells, just like peptides. They actually cannot differentiate. Like the MSCs utilized from umbilical cord derived tissues don't differentiate, they don't become a tendon. They heal, they begin to steal from you, through providing your body with the raw elements

Starting point is 00:16:15 and the raw materials to be able to heal and rebuild itself. Signaling to your body and then giving it your body cytokines, exosomes, extracellular vesicles, then they transfer their mitochondria, refueling your older, tired, weary cells, and then they're gone. Right. But the dogma that still lasts, just like the dogma from testosterone, is, oh my God, it's going to cause cancer.

Starting point is 00:16:39 If it can become a tendon or a ligament or a bone or a tissue, then what else could it become? I totally agree with you. In signaling molecules, you know, some of the best modalities, which is why I'm such a huge fan of peptides, are the ones that harness the body's ability to do its job on its own. So, you know, platelet-rich plasma, you know, PRP is one of those, you know, widely acceptable treatments for knees, hips, shoulder, rotator cuff, you know, repetitive use injuries. And you're essentially just capturing the patient's platelets, concentrating them in the site of

Starting point is 00:17:10 injury and sort of focus, not sort of, but directly focusing the healing power of the human body in a small area to accelerate healing. Well, you can do the same thing very similar mechanism through things like BBC 157, you know, this body protection compound actually enhances the body's awareness that there's an injury. And it calls the platelets and and other healing factors to that site. And you heal yourself by accelerating your body's own innate ability

Starting point is 00:17:39 to you. That's what I love about all this. That's what I love about it. It's like it's nature working. It makes so much sense. And yet it's met with so much resistance. I mean, I'm much easier convinced that I can enhance my body's ability to heal itself at an accelerated rate than that I can take something that my body doesn't recognize,

Starting point is 00:18:00 that you can't find a nature that is not found anywhere on the surface of the earth, somehow stick it in and magically is going to cause us to heal. And if you, this is how you know that what you're saying is spot on. While in one breath, the FDA makes this decision in a vacuum to essentially ban and shut down accessibility to dozens of peptides. At the same time, Merck and several of the big pharmaceutical companies

Starting point is 00:18:27 are attempting to patent over 200 different peptides. The very peptides that have been in the marketplace for 15 years that have been helping your patients, and our patients at Wayswell, people throughout the nation with amazing efficacy and minimal side effects, if any. And now big pharma is attempting to capture that. throughout the nation with amazing efficacy and minimal side effects, if any. And now Big Pharma's attempting to capture that. And so the truth always rises to the top

Starting point is 00:18:51 and we find it when we look a little deeper. But I'm just a huge proponent. I'm very optimistic that the future's bright and we're gonna be in a golden age. I think you even said it on Joe, like a golden age of regenerative and preventative care. I agree, man. If you're alive over the next five years, it's going to be your choice whether or not

Starting point is 00:19:08 you want to live to age 120 or 140. I truly believe that. And you know, the merger of big data, artificial intelligence and early detection now is giving people a chance to really get a hold of things at such an early stage. We're starting to detect cancers at stage zero. Yes. Right. I mean, how amazing is that?

Starting point is 00:19:29 We run that cancer screening. It's 200 types of cancer at stage zero with, you know, you can't say 100% survival rate. But when you catch it at stage zero. Is that the VOC? Which one is that that you're? I can't remember the genetics lab that we're using. But it's the same one that everyone's.

Starting point is 00:19:43 Yeah, we'll link it in the show notes if we figure it out. But it's amazing. And like the other thing we talked about with the DOD and a lot of these VA hospitals, our special forces operators and our military personnel are at a disproportionate likelihood of developing cancer in their lifetime. Same thing with our firefighters and first responders.

Starting point is 00:20:02 From all the chemicals and fire pits and all the things they've been around. Why would we not get proactive, predictive and pre-screen these people and make sure that we stop chronic disease in its tracks? And the same thing with blood work. Like I've heard you talk about the importance of blood work. We're using large language models now to assess the blood work, to tie into your wearables, to monitor your REM sleep, your deep sleep, your

Starting point is 00:20:26 heart rate variability. If you capture a DEXA and a VO2 max, and you begin to combine all those things into these large language models in the AI, it can assess and begin to predict out and model out all cause mortality. Yeah, it's so fascinating that artificial intelligence can take 700 trillion independent variables and create an actionable result. And I actually saw a model the other day of clinical trial being run in vitro

Starting point is 00:20:54 through nothing other than artificial intelligence. And what it was able to do was assemble so much information from tens of thousands of other clinical trials, from meta-analyses, and from a microbiological data, and say, if you expose this cell to this compound, in this media, this is going to be the result. And it predicted it with absolute precision accuracy. And so there's the possibility that we could actually run

Starting point is 00:21:21 fully randomized clinical trials in AI in an artificial intelligence lab without spending the 10 years to grow because it can take so many independent variables and say, I can weigh every single one of these potential outcomes and tell you exactly where this result. And then you run a side-by-side experiment and you realize, oh my God,

Starting point is 00:21:45 it reached the exact same outcome as the AI predicted. It just took us three years to get here. So it's a really exciting time. Brother, I'm so excited to be on this journey with you and other leaders like yourself that are outspoken, that are driving a stake in the ground for humanity and putting their reputations out there and really giving your time selflessly to this

Starting point is 00:22:05 Maha movement. It's a pleasure. Thank you, man. Thank you for all you're doing. We're all in it together and I know we can drive change. I truly, truly am more optimistic than I've ever been. After 25 plus years in health care, this is the first time I truly believe there is an opportunity to really reform and improve and drive health span. And we're all here hammering for it. I agree with that, Sam.

Starting point is 00:22:32 Thank you for coming on the Ultra Human Podcast, brother. And until next time, guys, that's just science.

The Ultimate Human with Gary Brecka - 182. Brigham Buhler: The Peptide Safety Data Reveals 75,000+ Patients With Zero Adverse Events

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