The Ultimate Human with Gary Brecka - 191. Dr. Darshan Shah: Stem Cells, Exosomes, and Plasma Exchange

Starting point is 00:00:00 Your genetics are never your destiny, right? Even if you have two copies, you can still prevent Alzheimer's disease. With preventative medicine, there's incredible diagnostics right now that we can detect heart disease, Alzheimer's, and other brain cognitive diseases, and also cancer very early. The possible early signs of shrinkage in the hippocampus being the leading indicator for things like Alzheimer's dementia, early onset cognitive decline, we're detecting cancers now at what they're calling stage zero.

Starting point is 00:00:25 And that's why we're seeing this massive resurgence of cancer, especially in like young people right now. I think a lot of us think of the immune system as something that protects us from foreign invaders, which it does. But the majority of the immune system's role is to police ourselves. Our immune system is overburden, overtaxed, and can't do everything all at once. And that's what leads to the acceleration of aging over time and also chronic disease. We talk a little bit about where a science of longevity and aging medicine is going. The emerging thought process in longevity medicine right now is one of the key reasons that we age is a

Starting point is 00:00:59 Ultimate Human podcast. I'm your host, human biologist Gary Brecker, where we go down the road of everything anti-aging, longevity, biohacking, and everything in between. And today's guest is not just a personal friend of mine, but I have been a client of his clinic. I have availed myself of many of his services, which are absolutely on the cutting edge of anti-aging and longevity medicine. I truly believe that the market and the science is 25 years ahead of where modern medicine is right now.

Starting point is 00:01:44 And Dr. Darshan Shaw is on the forefront of all of that. So you're in for a treat in today's episode. Welcome to the episode. Oh, that's an awesome intro. Thank you, man. Can you just go everywhere with me and intro me everywhere I go? Guru, Carl. Thank you, bad. Thank you. So, you know, there's so many things that I want to talk to you about.

Starting point is 00:02:05 And I want to get away from the conventional podcasting that I do and really talk about where the science of longevity and anti-aging, bio-optimization is. And we might as well start with my journey because I've had a personal journey with you in your clinic, Next Health. You're one out in L.A. The last time that I flew to Dubai, I had some time in Los Angeles. and I am an enormous fan of Dr. Mark Hyman, and I saw a post in an article where he had done this therapeutic plasma exchange with you. So, of course, I start going down the rabbit hole

Starting point is 00:02:41 and pulling all of the PubMed articles on it. And this was a mechanism to take the plasma out of your body and replace it with sterile albumin. And I'll say it was two needle sticks, but it was a painless procedure. I was chilling the whole time, just chatting it up with you. My wife was there. My pre and post labs were amazing.

Starting point is 00:03:05 I'm happy to share those and put them into the show notes. I'm an open book on those things. We talk a little bit about therapeutic plasma exchange, and then I want to really start picking your brain about where the science of longevity and aging medicine is going. Yeah, absolutely. And I think therapeutic plasma exchange is a perfect example of where the science is going. Because what's really cool about therapeutic plasma exchange is this is a technology.

Starting point is 00:03:30 It was actually FDA approved in 1970 to be used in the hospital. Wow. Was it for sepsis or? No, it was actually for people that had a condition called Wallamstrom's disease. A Wallenstrom's disease. Yeah, exactly. I mean, that's how you're supposed to say it. And it's where the blood gets really thick.

Starting point is 00:03:49 And so when you do this, use this machine, you can remove the thick portion of the blood, the plasma, and then re-infuse the red blood cells. because obviously we need our red blood cells to carry oxygen. Now, this machine that does this is basically a giant centrifuge. It's super complicated, but it's a giant centrifuge that, you know, when you take a vial blood and you put in a centrifuge and you spin it down, it separates into the red cells at the bottom and the top part, the 45% is plasma. That's a liquid portion.

Starting point is 00:04:15 So this just does this on a mass scale for your entire blood volume. So then they started using it for other diseases that built up something toxic inside your plasma. So they're autoimmune diseases that build up immune complexes. And for years, I remember training as a resident, people were coming even with like overdose of certain medications and they would be in the plasma and they would die unless they got the aphoresis done. Aphoresisans of plasma exchange are two kind of interchangeable terms. Okay. Right. So we used to call it aphorias. Yeah, they call it plasma phoresis too. Total plasma phoresis, total plasma exchange. Exactly. Yep. And so we would use this machine in the emergency room when

Starting point is 00:04:56 someone who comes with like a dejoxin toxicity. And so that would completely detoxify that. Because basically anything that's living in your plasma that is toxic to your system can be removed with this machine. And what's cool about it is you're not adding something to your body. We're not giving you a drug or a chemical. You're just removing the bad stuff that's circulating in your plasma. I mean, there's good stuff in the plasma too, right?

Starting point is 00:05:18 You have growth factors and platelets and all kinds of things in there. They're doing a lot of good. So is there any detriment to taking those things out of circulation? and how do they get replaced? Yeah, great question. So absolutely, you know, we need the things that are in our plasma as well, but your body is so incredibly good at regenerating those, mostly within 24 hours.

Starting point is 00:05:37 Your growth factors... 24 hours. Yeah, regenerate everything. The only thing that takes a little bit longer is immune globulins. Immune globulins are, you know, the infection fighting mechanism of a part of our immune system. Those take a little bit longer. So we give people that are at risk, IV, IG, IV immune globulin after the treatment.

Starting point is 00:05:55 if you're at risk for infections. Okay. But otherwise, most of the other things that circulate in our plasma like hormones and growth factors, those are replenished within sometimes even less than 24 hours. Wow.

Starting point is 00:06:08 You know, I noticed that after I had it done, luckily I was actually boarding a flight a few hours later and it was a nonstop flight to Dubai on Emirates, which is actually nicer than spending the night in my house. It's pretty awesome. I'm trying to fast on the airplane, food service is so good they got showers um so i had like the best airplane sleep i've ever had yeah and um because i felt you know just a good kind of tired and then when we landed it was like the light bulb

Starting point is 00:06:39 went on and i felt like i'd taken a limitless pill i was you know i was solving multinational crises in my head it was like you know i just felt like i was really just alert and and just oriented and cognizant i felt very zen, just kind of clean from the inside out. It's a really hard thing to describe. My wife was like, babe, your skin and you're like the whites of your eyes, you know, looks great. And like I just took in a, taking a fresh hour or something. And I felt it for a few days.

Starting point is 00:07:14 And then, you know, I went back to just feeling great because I feel pretty good all the time. But I think that these kinds of therapeutic applications, really dovetail with a theory that I've been embracing a lot lately. You know, I've talked to Dr. Peter Diamantis and a lot of leading minds in longevity medicine and anti-aging, bio-optimization, whatever you want to call it. And there's this, I think, general theory emerging about aging called immunophatigue.

Starting point is 00:07:47 And the sort of progressive overloading of our immune system, you know, and it's multifactorial. It's not like one thing. It's not like just glyphosate or just a vaccine or just poor sleep. But it's, you know, thinking of it like a bucket. It's kind of these just consistent ways that we are just over, you know, burdening our immune system. Right. Absolutely.

Starting point is 00:08:12 And I wonder if you would talk about that a little bit or if you agree with that kind of concept. Oh, not only do I agree, but I think the emerging thought process in longevity medicine right now is one of the key reasons that we age. is immunosinessence and immune aging, as you called it. Because you're right, we are constantly throwing stuff at our immune system more than we ever have in human civilization. You know, there's 150,000 toxins in our environment that were never there just eight decades ago. 150,000.

Starting point is 00:08:38 150,000 that we know of that were never there 80 years ago. I think the FDA lets them all go in our food supplies. Yeah, food, air, water, they're everywhere, right? And so what's helping us take care of that, eliminate that? So our immune system, then our immune system is constantly fighting off more and more infections. We're seeing more and more infectious disease. Our immune system is also responsible for fighting off cancer. And that's why we're seeing this massive resurgence of cancer, especially in like young people right now. So many more people are getting cancer

Starting point is 00:09:10 and people are wondering why. Well, it's because our immune system is overburdened, overtaxed, and it can't do everything all at once. And that's what leads to the acceleration of aging over time and also chronic disease. So you're absolutely right. Yeah, I mean, I think a lot of us think of the immune system as something that protects us from foreign invaders, which it does, right? That's one job, that is.

Starting point is 00:09:30 And bacteria viruses, what have you. But the majority of the immune system's role is to police ourselves. Absolutely. Right? I mean, it keeps order in the body. And cellular senescent, these cells that are also called zombie cells,

Starting point is 00:09:46 whatever you want to call them, these are those cells that are kind of hanging around. They're still living. but they can no longer perform their function. Maybe they're a red blood cell that's not carrying oxygen or a platelet that's not capable of transporting growth factors or an immune cell or a white blood cells that can't really mount an infection, you know, a response.

Starting point is 00:10:05 And I think the idea of, you know, cleaning these out, getting rid of the lazy employees in our company and putting people back in those seats that are going to really work hard and do their job, it's kind of a great analogy for how we can bolster the immune system and maybe fight back father time. Absolutely. I mean, you know, senescent cells too. The other thing they do besides just not work well is the actually secrete toxic substances to the neighboring cells, which cause the neighboring cells to then also become senescent

Starting point is 00:10:36 or more not as functional as they could be. And so it's imperative to remove senescent cells from our system. Our immune system does that, but it needs a break from fighting infections, fighting toxins to do that, right? And so what the plasma exchange does is, gives our immune system that break. It's like an oil change for our body. It completely removes all the toxins from the plasma. So immune system can now be like, I can take a breather and I can do my job. Right. And so. And you know, there are other technologies that are out there. I've also done EB-O-2 ozone, which I'm also a big fan of, you know, my daughter and I and my wife actually recently had, I had mild mold exposure, but I also had pretty significant metal toxin.

Starting point is 00:11:21 I had this water machine, a doctor that I trusted because he was very well credentialed. Thankfully, I didn't tell anybody about it on social media or anything. So I had this water machine and it was a modified welder from China. And he convinced me that it was restructuring my water and basically, you know, there were a lot of, there's a lot of heavy metal toxicity coming out of it. And my son and I, my daughter, to a lesser extent, my wife, I was drinking two to four liters of this water a day. Structured water. Structured water. Yeah, structured water.

Starting point is 00:11:52 And, you know, I noticed that I started having some of the symptoms of heavy metal toxicity. Lo and behold, I did this provoked metal test with, you know, chelation. Yep. And then an eight-hour urine test. In DMSA. Yeah, yeah, DMSA. Which, by the way, if you really think that you have heavy metal poisoning, you know,

Starting point is 00:12:10 sometimes it's difficult to find the metals. Yeah. Right. Not like a lot of time you urine test and they don't really show up. Right. Well, the problem is because the heavy metals and the, toxins, they end up in your organ tissues. And so when you're doing a urine test, for example, or even a blood test, if you're not doing a provoked test, you're not going to get an accurate

Starting point is 00:12:29 representation of what's really living in your tissues. So we actually do the same thing before a plasma exchange. Oh, wow. We provoke it out of the tissues, get it into your plasma, and then get rid of all of it. Oh, wow. So you'll do like a chelation. Exactly. And then a plasma exchange. Right. Immediately after. Wow. So if you're suffering for every metal toxicity, this is like, you know, chelation on steroids. Wow, that's, that's really good. I did an oral chelation protocol and then I did some EBO2.

Starting point is 00:12:55 Talk to me a little bit about the differences maybe between therapeutic plasm exchange and EBO2 because there's also a filtration system there. And they add ozone. So what are the main differences there? Absolutely, yeah. So there are two different treatments. And even though there's some overlap and what they're useful for, we do both of them in our clinic and some patients get both of them.

Starting point is 00:13:15 And so EBO2, the main effect is exerted through. exposure of the blood to ozone, which creates an oxidative stress that causes cells to renew and also can kill bacteria viruses, fungi that live in your system. Okay. Now, the filter that they also put on the machine can also filter your blood as well. What plasma exchange does is it does a complete removal. And so there's no oxidative stress that's really put on to your cells. It's just removing whatever's in the plasma. Right. And so there's different applications for both. A lot of times, if someone comes with like mold or lime toxicity, we recommend EBO2. If they come in with heavy metals, we'll do the provoked plasma exchange.

Starting point is 00:13:56 And if someone's just doing it for longevity purposes, we'll kind of talk about both of them. But I'm a big believer in plasma exchange being one of the keys, I think, to longevity. We can talk about some of the science behind that too. Yeah, I'd love for you to go into the science behind it and maybe even talk about how, I mean, right now these are not inexpensive treatments. Because, you know, the machine is very sophisticated. A practitioner has to be on site. the entire time, lots of sterile vials of albumin because, I mean, I got, I think, about two liters of, I mean, it was a big.

Starting point is 00:14:26 You had almost three liters of plasma that we removed. Yeah, I was really surprised that all of that came out of my body. But I think as time goes on, you know, these therapies will become more accessible, more affordable, obviously. That's what I'm going for. As in everything in modern medicine, you know, the science kind of leads, um, in know, it stays maybe a decade, decade and a half ahead of where, you know, the actual mainstream is. But it's nice for people to know that we're not stuck in the state that

Starting point is 00:15:00 we're in. You know, there are things that we can do to extend our health span, potentially even extend our lifespan. And I think, sadly, when you look at aging, one of the things I talked to Peter DeMontas about was, you know, he said, you know, right now, you know, before we even open the discussion about life extension. Sure. We should really open up the discussion about health extension. Absolutely. That's what I talk about all the time.

Starting point is 00:15:24 Yeah. Because people are dying, let's say, at 82, but you really began to die in your 70s. Exactly. And your quality of life went down so bad. And I think most of the people that are listening to this podcast would say, rather than extend me another 10 miserable years, I'd rather slide into the grave, you know, like margarita in one hand, jukebox on my shoulder. Right.

Starting point is 00:15:45 Right. Yeah. I mean, to me, people ask me like, what kind of doctor are you? And I say, you know, I'm a longevity and health optimization doctor, but I want to redefine the term longevity. To me, longevity means adding healthy, productive, vibrant years to your life up until the very end. Because you can add 30 years to an 80 year old's life and get them to live 30 more miserable years. Like you said, you can live up to 85 and feel incredible. Like, you know, the blue zones. And there's this guy, Errington, who works out of Gold's, gym in Venice Beach and he's 91 years old. He's buff like you and he's super sharp. Yeah. He can lift more weight and he can also think faster than people's half his age. And I've talked to this guy. Wow. And so I look at that guy.

Starting point is 00:16:29 I'm like, it's absolutely possible for people living right now to achieve this. It's just getting into the right routines and habits. And it doesn't even need to take expensive procedure, which we are trying to bring down the cost exponentially. Just like, you know, you just had a full body MRI. You're telling me that used to cost 20. $20,000 to do it. Now it's like $2,000, right?

Starting point is 00:16:49 Yeah, yeah. Everything goes down. Right, exactly. And I think, you know, for right now, it's such an exciting time to be, like, I wake up every day like a little kid like I get like giddy excited about it. You know, we were walking around looking at all my biohacking devices before the podcast, which is a lot of fun. But, you know, this is such an exciting time in medicine and functional medicine and

Starting point is 00:17:13 and longevity research because, you know, you've got. artificial intelligence coming together with big data, with things like early detection, and you put these three components together and, you know, we're detecting cancers now at what they're calling stage zero, right, circulating tumor cells before they become a nodular tumor. And I think the old, you know, a lot of the old diagnostic mechanisms waited until you actually had a disease process. But it's exciting with AI to think that, you know, you're on the pre-path to this and we can nip it in the bud now.

Starting point is 00:17:47 You know, I remember when we first started our clinic. Initially, we started in an urgent care center and we had a doctor that was an urgent care doctor. And so we tried to go the traditional like insurance route, which was brutal. Brutal. I lived in that world for 20 years. So difficult.

Starting point is 00:18:06 And for a board certified physician to spend the majority of their time negotiating with an insurance company about whether or not they have the authority to order a biopsy or a certain set of tests is amazing because I remember how frustrated this physician was because he's like, man, I just literally spent two hours on the phone with a, you know, a 20-year-old non-college graduate debating about whether or not I had the authority to order a biopsy. Yeah, that's crazy.

Starting point is 00:18:29 And so that administrative burden. And one of the things we saw over and over again was there was no attention to the predisposition of disease. We would have hundreds and hundreds of, you know, patients come through this clinic and they would be pre-diabetic, for example, and the insurance company say, we don't do anything for that. Oh, exactly. And sometimes they would even say, well, he's really close to being insulin dependent.

Starting point is 00:18:53 And as soon as he becomes insulin dependent, you know, we'll take care of him. Right. And I was like, man, it's just so amazing. It's just so incredible that mentality. If you want protein to build lean muscle, but without the caloric impact or need to cut, you need perfect amino. It's pure essential amino acids, the building blocks of proteins in a precise form and ratio that allows for near 100% utilization in building lean muscle and no caloric impact.

Starting point is 00:19:19 So we build protein six times as much as way, but without the excess body fat we normally get during bulking. This is the new era of protein supplementation and it's real. If you want to build lean muscle without having to cut, you need perfect amino. Now let's get back to the Ultimate Human podcast. Well, I mean, that's why I left traditional medicine, right? because with traditional medicine, you can't get anything paid for. And, you know, where the financial incentives are, that's where the business goes.

Starting point is 00:19:47 You can't get anything paid for until there's a diagnosis of a disease. So there has to be either a numerical one, like you said, you have to be diagnosed with diabetes or an anatomical one that you need to have a surgery done. Everything else before that, that system was not built for that, right? It was built to, you know, thank God we have the Western medical system. If you get hit by a bus, if you get a heart attack, you get diagnosed with stage four cancer. Thank God we have that system.

Starting point is 00:20:13 But we really need to focus on creating a new system, which is what you did and what I'm doing at Next Health, that is a health-focused system. And this prevents you from going into that Western medical system. Right. So I feel that, you know, I think there's a lot of frustration with the Western medical system, and I totally get it, right?

Starting point is 00:20:30 But I think just people need to get their heads wrapped around. That's there for a reason. Another reason is taking your health into your own hands and focusing on your health and clinics like, you know, what you had and next health, we're going to keep you away from the disease management system because there's never built to reverse chronic disease in the first place. Right. Yeah, it's so true.

Starting point is 00:20:51 So I would love to talk more about, you know, the additional science behind longevity. Yes. Behind aging because, you know, in addition to this theory on immunophatigue, there's a lot of research now around mitochondria, mitochondrial health, you know, the powerhouse. our cell. I think we ignored these 110 trillion little organelles for for decades. And now we're realizing that, you know, as the powerhouse of our cell becomes metabolically sick, the cell follows. And as the cell follows, the organ system and the organism follows. And it's so fascinating now that we're down to this little organelle, this little battery house, and trying to find ways to service

Starting point is 00:21:34 this and maybe even increase, you know, its density, proliferate these. as a way of, you know, helping the body function better. And it reminds me of the fact that most of the really good anti-aging medicine is really just trying to get back to what God gave us and less of what man makes us. Right. Because the greatest pharmacy is right here. I always say, you know, we're all born with a hundred billion dollar pharmacy. It's living in your gut, you know.

Starting point is 00:22:06 We'll say you mind for 25 million right now. Yeah, exactly. We're all born with it. We just have to use it right and give it the substrates and the tools and the environment it needs to give us what we need back. And then you can avoid all the pharmaceuticals, you know? Yeah. So somebody that's beginning this journey, you know, it's sadly can be really confusing.

Starting point is 00:22:25 I mean, if you get online right now and start Googling around, you will get paralysis of analysis, right? It's like trying to buy a stock chart with 50 different charts, one time you buy, sell, hold. And I think people get paralysis of analysis. this. They don't know what works, what doesn't. So somebody that has the basics covered. And by the basics, I mean, they're paying attention to their sleep. They're eating a whole food diet. They're getting decent amount of exercise, right? And it may be a psycho biohacker. They got a good handle on basic biomarkers or taking some supplementations. Where did they start

Starting point is 00:23:00 this next level of their journey? So we have this entire program laid out for our patients. And I put it together when I first started my clinics and it's worked extremely well for thousands of our patients right now. And we call the wellness wheel. Basically a wheel of 12 aspects of your health divided up into four categories. What you just mentioned was lifestyle medicine, right? That's... Love that word. Yeah. Nutrition, metabolic health, exercise and movement and sleep and recovery. Those all come first. If you don't do those three things first, everything else is harder to make any gains on, right? Second aspect of our program is preventative medicine.

Starting point is 00:23:38 That's where we focus on heart health, brain health, and your immune system would prevent you from cancer. With preventative medicine, there's incredible diagnostics right now that we can detect heart disease, Alzheimer's, and other brain cognitive diseases, and also cancer very early. So then we check those three boxes for all of our patients. Then we move on to my favorite topic, which is functional medicine, right? Yeah. Functional medicine is focusing on.

Starting point is 00:24:04 on gut health and optimizing that, optimizing your hormone health, detoxifying your system and getting your mental health and stress management right. And so that's what Dr. Hyman talks a lot about in his books and he and I work very closely together. Once you get to that functional medicine part of it, I say it's my favorite because not only does it help you reverse and prevent chronic disease, but getting those right, you start feeling great. Right. You feel vital again, you know? I try to set that hook for my clients early on. Like, you know, dietary and lifestyle and supplement changes. You know, I try to give them a win out of the gate so that they really subscribe to that journey, right?

Starting point is 00:24:44 I mean, that's what we did with Dana White. You know, we had a fascinating conversation before we came on the podcast, and you were talking about the new Pernovo scan, or it was Pernovo, right? That is scanning the brain and looking at the hippocampus. and the possible early signs of shrinkage in the hippocampus being the leading indicator for things like Alzheimer's dementia, early onset cognitive decline, because, you know, I feel like the majority of these diseases we don't start to address until not only do we have them, but we're pretty far progressed. That's the problem, right?

Starting point is 00:25:25 In the disease pathway because, you know, you can't find your keys in your wallet. And then you find your keys, but they're in the refrigerator. Then you start parking in the neighbor's driveway. And then finally a spouse or a loved one goes, we need to get this checked out. And then bang, you've got early onset dementia or Parkinson's or Alzheimer's or what have you. And now that process has taken hold. Yeah.

Starting point is 00:25:51 Then it's hard to write the ship, right? Right. And now you're on the hamster wheel too. You're on the pharmaceutical hamster wheel. A lot of that is disease maintenance and symptom. management. But I was really fascinated by it. So, you know, in stage two, when you look at some of these diagnostics, talk to me a little bit about the shrinking hippocampus. Yeah, absolutely. Okay, so what you're referring to there is, I'm going to have mind check next. Is preemptive of

Starting point is 00:26:17 Alzheimer's disease before it's too late. And there's a couple of incredible innovations in that field right now. One is we can use artificial intelligence and look at the hippocampal volume. The hippocampus is the memory center of your brain. And before, Before you start losing your memories, your hippocampus start shrinking. And then we can compare that volume through an MRI of the brain to people that have normal cognitive powers in your same age group, right? And so then we know that your hippocampus is maybe a little bit smaller than somebody else. And then we can start taking proactive steps to reverse that tie, to write the ship. Because like you said, the earlier you write that ship, the easier it is to sail it in the right direction, right?

Starting point is 00:26:59 And it gets too hard when you've already been diagnosed with full-blown Alzheimer's. Right. Now, there's another test. I don't know if you know about this one, the P-Tal-217 test. Have you heard of this? No. Is this a genetic test? This is an incredible blood test that measures a protein biomarker of Alzheimer's disease.

Starting point is 00:27:16 Wow. And actually gives you a level. There are genetic markers for Alzheimer's. There's APOE, which is a genetic marker, right? And that gives you some indication of your risk of Alzheimer's. So if you have two copies is 16x and one copies, four X. Your genetics are never your destiny, right? You can still, even if you have two copies,

Starting point is 00:27:32 you can still prevent Alzheimer's disease. You just have to be intentional and diligent about it. You need to look at all the root causes of why we age and don't have longevity and work on all of them. But Ptow 217 is incredible because this is actually a blood biomarker that's highly correlated to the scans of the brain that tell us whether or not you have Alzheimer's. So this, and actually has a level.

Starting point is 00:27:54 It goes from like zero all the way up to, you know, hundreds. And so the higher your level, the more likely you are to have Alzheimer's disease, but was really great about this biomarker. It can tell us decades before you have Alzheimer's, if you're, and go ahead. Decades. Decades. And you can track your interventions and see if they're working because you can see the biomarker actually come down.

Starting point is 00:28:15 So Dr. Dale Bredesen, he wrote the book, End of Alzheimer's. Incredible guy. He's one of the main scientists talking about this. And it's truly an incredible world we live in right now. So somebody has this protein. say they have the api gene and they have a predisposition, one or two copies. And obviously that raises a level of concern. And then they do this protein test.

Starting point is 00:28:37 What are they going to get from this protein test? And like what are kind of some of the actual steps they would take? Yeah. So they're going to get a number or a level. It'll tell them how far they, how far along you are in the disease progression towards Alzheimer's. And what you want to start doing then is putting into place lifestyle changes. A lot of the ones, you know, we talk about eating whole foods and staying away from seed oil. and processed food and getting better sleep and exercising more and having less sedentary time,

Starting point is 00:29:02 obviously. But then there's additional things that you won't need to do to reverse this. And one of the biggest reasons people develop Alzheimer's disease is a massive amount of toxic exposure as well. So you want to test for heavy metals, mold, Lyme disease, et cetera. Those can also increase your risk of Alzheimer's. Plasma exchange has been shown in a really great research study called the Ambar study that Dr. Kiprov did to actually slow down the progression of Alzheimer's disease by removing a lot of

Starting point is 00:29:30 these toxic substances from your blood as well. So there's a lot of things you can do that are free and a lot of things that you can do that might cost a little bit of money, but it can absolutely arrest the process and turn it around. Wow. You know, I've, I've met people in my travels from all over the world that have had all kinds of conditions that have now gone into remission. And what's amazing about a lot of these conversations is I had a woman, for example, I spoke at a conference. She was not a client of mine for the record. But I had seen her at the same conference almost two years earlier.

Starting point is 00:30:13 And she had just begun to lose sight almost completely in one eye because of multiple sclerosis. And we were having a conversation. She found a great functional medicine doctor. and this functional medicine doctor didn't believe that she actually had multiple sclerosis. He said, I'm not going to accept the diagnosis until I do mold mycotoxin, heavy metal, virus, and some parasite testing. And lo and behold, she had severe heavy metal toxicity, which had flown under the radar for years, probably why she was unresponsive to therapy.

Starting point is 00:30:47 And she had a, I want to say it was chronic Lyme, either chronic Lyme. the Chronic Lime or Chronic West Nile. And she got those addressed. And within six months, her eyesight was fully restored. And now they've recanted this diagnosis of MS diagnosis. And I think a lot of time, you know, I'm not a physician. You are. I'm not licensed practice medicine.

Starting point is 00:31:10 But I think a lot of time, just looking from the outside in and watching, you know, 150,000 clients come through our clinic system and just reading medical records for so many years, I think what happens very often in medicine is someone is diagnosed with a condition and call it whatever you want and anchor diagnosis. Once that's in the medical record, as they get passed from doctor to doctor or specialist to specialist, no one ever really goes back and says, I wonder if, you know, Dr. Shaw did, he says she has rheumatoid arthritis, I want to look at the said rates and, you know, the rheumatoid factors and all these other things. And so once you are diagnosed as that patient, you are kind of always that patient. Absolutely. And there tends to be this kind of continuity of care where we take whatever disease we're told the client or the patient has.

Starting point is 00:32:04 And we just sort of continue along that path. So true. And this is purely observational and don't have a clinical study to back this up. But I would say if you were diagnosed with any kind of severe condition, I would first go look for these kinds of pathogenic invaders, your toxicity level, your heavy metals, your mold mycotoxins, viruses, you know, where do you fall on that? Right. I'm a hundred percent believer in that.

Starting point is 00:32:33 And, you know, when I trained in medicine, this was 30 years ago now. I'm aging myself, but it was a while ago. Well, you look great, man. Thank you, man. But 30 years ago, and this is still true today, medicine is trained in silos, right? And so the problem with that entire model is it doesn't take into account the effect of all these systems working together and pathogens affecting multiple systems at the same time. So no one's really looking at what could be affecting the brain and the joints and the gut.

Starting point is 00:33:07 No one's looking at that. Yeah, you've got a GI for this. You've got a rheumatologist for that. You've got a therapist or a neurologist for that. That's exactly what happens. Super bifurcated, right. Right, right. So there are certain categories of diagnosis.

Starting point is 00:33:18 that people need to do when they have something that's bad or they're not recovering from and they're just frustrated. And these indolent infections, you know, molds, Lyme disease, heavy metal toxicity, gut health issues, leaky gut. These are all diagnoses that were never considered until we got to root cause medicine, functional medicine, where we're like, wait a minute, all these systems functioned together. And there's these root causes of disease that can be leading to all of this. So let's look for that stuff. And so, you know, thank goodness for Jeffrey Bland, Mark Hyman, and these guys really bringing that to the consciousness of medicine. The problem is functional medicine is not taught in medical school.

Starting point is 00:33:58 So once again, the Western medical system has its role, right? You have people, thank God they're rheumatologists and there's neurologists. Oh, yeah, yeah, very good at interventional medicine, crisis medicine. I mean, we're probably the best in the world. Best in the world, right? I mean, the stuff we do for people, save lives. Yeah. But if you are frustrated with the typical, you know, referral to multiple doctors and you're not

Starting point is 00:34:18 getting anywhere, you're getting worse? Absolutely. One needs to see a functional medicine doctor bring it all together and just press a reset button and see what else could be going on. Yeah. And I think when you look at human physiology and the effect on methylation and all of these other multifaceted systems, very often, you know, it looks like if you think about all these spokes on a wheel and they all have a hub, you know, very often we're out there chasing the spokes of the wheel. This person has a mental issue. They have an autoimmune issue. They have an inflammatory issue. They have a gut issue. They have a cardiac issue. And it's not like the whole world went to hell in a handbasket at one time. You know, very often one thing goes

Starting point is 00:34:56 wrong that causes everything. And if we can find that thing, that underlying chronic viral, that severe heavy metal toxicity, that undiscovered, you know, mold toxicity, which I hear a lot of folks online talking about how that mold is just completely made up. And I'm telling you it's not um uh everybody has mold and you know human beings have had mold for centuries and we've never gotten sick from it i i find that to be patently false um and and so you know getting back to you know the one thing that could have potentially caused everything i think such a message of hope for a lot of people hey guys let me tell you about one of my favorite new hydration drinks now this is for distance athletes hits cardio exercises people that sweat a lot or

Starting point is 00:35:42 exercise intensely and a game is a hydration drink it has a eight essential vitamins. It has all of the electrolytes, the entire suite of B vitamins. Before you freak out and read that it has 21 grams of sugar, which it does, the sugar is coming from natural cane sugar and honey, my preferred mechanisms for getting glucose into the blood during intense exercise. It also has natural flavors, but these natural flavors don't come from bacterial fermentation. They actually come from real citrus fruits, and the color is from vegetable juice, not artificial dyes. So next time you're looking for a great hydration drink and you're exercising intensely, a game is your choice.

Starting point is 00:36:18 Now, let's get back to the Ultimate Human podcast. It really is. And, you know, I can tell you at our clinics, you know, just from patients I've talked to, when you completely figure something out for someone and reverse the entire destiny of their health and they're, and some of these people, they are so sad and depressed over what they're going through that they just don't want to live anymore. And you find out that one thing and you treat it within six months, I mean, it's a game change it for people. So, you know, like I always say, you know, if you're frustrated with what's going on

Starting point is 00:36:49 right now, you have to take your health into your own hands, become the CEO of your own health, learn about your biomarkers, learn about your disease, and start getting a team together of people to figure this out. Yeah. You know, I think the pandemic, if it did have any favors, and it's hard to think about the pandemic doing its favors, but I think if it did, it sort of woke people up to their own wellness and said, you know, I need to become a little bit of a citizen scientist, take this kind of into my own hands and go on this journey on my own behalf. So I want to move on to the next level. You know, there's a lot of talk and I think a lot of misconceptions,

Starting point is 00:37:25 misunderstanding about stem cells, exosomes, what I would call these biologics that can have phenomenal impacts in the human body. And, you know, I for a while was the health services director for the NFL alumni association of Athletica. So we saw lots of repetitive use injuries, you know, like knees, hips, shoulders, rotator cuffs. And our physician did a lot of intraarticular injections with a lot of stem cells, exosomes, other biologics, and saw some phenomenal results. The one thing that we did notice was that when you put even great biologics into an unhealthy biome, people that had severe insulin resistance, a really elevated hemoglobin A1C, high fasting glucose, super high inflammatory markers like C-reactive protein or their liver was under stress or the kidney

Starting point is 00:38:24 function was low, low EGFRs on some of these other conditions, they had demonstratively worse outcomes or by worse outcomes, I mean, they just didn't have any no resolution or the benefit. So I wonder if you might just talk a little bit about stem cells to my audience and what is the difference between, I mean,

Starting point is 00:38:46 not all stem cells are created equally. No. Right? They come from amnion, corion, um, billicle cord, cord, cord, cord, blood. Um, you know, blood, uh, cord blood. They come from all kinds of places. Um, first of all, do you guys use stem cells? We do. Okay. We do use them. And, um, so you're a believer. Yes, absolutely.

Starting point is 00:39:02 And what type of stem cell and why? Where do they come from? Right. So, you know, the whole stem cell world, because of the FDA has severe restriction on the United States, it is not allowed the stem cell science to really proliferate as a should of, right? And you can get all, you know, you can get. I think that might change, you know, under Bobby Kennedy.

Starting point is 00:39:22 I think a lot of these ceiling might get raised a little bit. Well, we should do what Japan did. Japan, you know, they recognize the value of stem cells and they just created a new body to deal with regenerative. medicine, a new governing body to deal with regenerative medical science that was separate from the FDA. Because the FDA is graded, you know, evaluating chemical compounds for drugs, but they're not great at looking at regenerative therapies. And you could argue as, you know, not to get conspiracy theory on it, but stem cells can put a lot of these pharmaceutical companies out of

Starting point is 00:39:50 business, right? Because they have so many varied applications. And so, yes, you know, I was just talking to your people here about stem cells. You have to be extremely careful where do you get your stem cells from? We know some common friends. that have had lots of problems with stem cells. I know people that I've had, you call it miracles happen, and I know people that have had debilitating, even life-threatening types of infection. And these were very well-credentialed clients in them of themselves.

Starting point is 00:40:19 Some of them icons in our industry, two of them that come to mine readily. So talk a little bit about the stem cells. Where do they come from, where they harvested, what are some of the applications that you find that they're a really good thing? So there's a couple different places you can get stem cells from in general terms. One is from your own body, right? Yeah, host-arized.

Starting point is 00:40:39 Yep, exactly. And so you can get either your blood, stem cells live in your blood. They live in your bone marrow. They live in your fat. And you could take those stem cells and then you can multiply them and give them to your, give them back to yourself where you need them. And you can't multiply them in the United States, but you can go out of the country to get the multiply.

Starting point is 00:40:57 That's what they call expand or minimally manipulate. Right. He's that term. Right. So in the United States, we need to not manipulate the stem cells. In other countries, they can, and they put them into petri dishes, and then they expand the cell lines. So say you extracted a million stem cells, you can then expand it into 10, 100 million stem cells.

Starting point is 00:41:19 And that's what they can do. In this case, if they're derived from the host, those are your own stem cells. So they can either tap your bone marrow, like your hip or your fat, like a little liposuction. And for the most part, you can take. those stem cells if you don't expand them and you can put them back into the host right um and joints knees hip shoulders rotator cough and people do that people do that a lot and people even do that with PRP they'll just take even the plasma from your blood and they'll put it into your shoulders and your knees we do that therapy as well and that's that's also helpful um the problem with your older stem cells is that

Starting point is 00:41:53 they're older right they don't have they're the age of the host right so i'm 54 so they're my age Your age, right? And especially if you're unhealthy to begin with, they have the same health qualities as your overall biology, right? So if you are, say you have diabetes or you have inflammation, your stem cells are not going to be healthy. So you're just injecting unhealthy stem cells back into the joint. And they can't do anything powerful there. That's probably why what you guys are seeing there in your clinics with the NFL, right? Now, you can get also stem cells from basically donated blood or placenta from babies that are just born, right?

Starting point is 00:42:33 Now, this is where it gets a little bit hairy because you need to make sure that the sores, the baby... They're not actually from the fetus. No, they're not for the fetus. They're from the... Yes, totally illegal. Yes. Because I think there is also, like,

Starting point is 00:42:47 people get online, there's all these sinister things that they're ground up fetuses or that they harvest the fetus and make the stem cells. That would be very unethical and immoral. but these are placentas and umbilical cords that are otherwise going to be discarded at first. They're going to be thrown away so they're donated for science and then they actually harvest the blood or they harvest other parts of the umbilical cord or even the placenta

Starting point is 00:43:11 and then they take those, purify them, test them, and then inject those. Now, these have a lot more power behind them because they're younger, they have more exosomes and they don't have all the, they haven't been exposed to a lot of inflammation in their life. Yeah, they're very early stage of life, right? Brand new, right, exactly. So that is important to understand the sourcing of these, but it's also important to understand that when you take these cells and you multiply them in a petri dish, you're also, it's a petri dish.

Starting point is 00:43:38 It can grow infections. It can grow other bacteria and you can inject those into people and that can get you into trouble as well. So you have to be really cognizant about the lab that's getting these, right? And also, obviously, you want to make sure the mother and the baby are, don't have any other infections. they don't have anything else going on in their biology, viruses, you know, things that are being tested for as well. So as long as you're sourcing your stem cells responsibly, you're dividing

Starting point is 00:44:06 them responsibly. You know, a lot of countries like Panama, they have excellent labs that can divide the stem cells, then you're going to be safe. And they could have massive amounts of applications, not just joint injuries. People are looking at stem cells IV to create regenerative effects because the stem cells can hone in on where you have inflammation. Yeah. They can go to those tissues and encourage healing of any area of inflammation, you know, um, wherever, wherever you might have it, liver, bone, anywhere. And did they work by, um, if I did, um, an intravenous infusion of, of stem cells, let's say, what's called mesenchymal stem cells, right, from umbilical core blood or

Starting point is 00:44:43 Wharton Shelley or, or what have you, you put these into the body. What I find fascinating is they get into the bloodstream and how do they know where to go? Yeah, they have an incredible ability to hone in. areas of inflammation and that need repair. And that's what stem cells are built to do, right? And so they are attracted by cytokines. So cytokines are signals that injured areas produce. And the stem cells just follow those to those injured areas. And they get there. And then the stem cells have exosomes within them. These are little packets of basically healing substances that get secreted into the tissues. Growth factors. And then they encourage the tissues in those areas to heal

Starting point is 00:45:23 and the stem cells in that area to divide. Yeah. I mean, it seems to me that if you do the chain of custody and the research on the cell line first, and you know that you have a sterile product, you know, you have, or at least aseptic product, you know that it's gone through the right pathology testing, you know, viruses, bacteria, what have you. It seems like for the, you know, in the grand scheme of things, for the volume of procedures, these are very safe. They can be very safe, right? Absolutely. And so we've never had, knock on wood, any problems with any stem cells that we've done ever. We source all of our stem cells from the United States. We follow the entire chain of custody. And they are extremely safe because their body's natural molecules and signals that we've evolved to live with for all of humanity. Yeah. You know, I know that there's a concern sometimes that these stem cells could carry the MRI vaccines, other things, because. because, you know, these vaccines can become intertwined into the DNA.

Starting point is 00:46:27 And stem cells have DNA, unlike exosomes, which don't carry DNA. They just carry high molecular rate, high ol'uronic acid, growth factors, other really beneficial things. So do you store stem cells that are pre-COVID or is there any way to test to see if maybe that mother was vaccinated for people that don't want to take that risk? You can definitely ask about the sourcing of the stem cells if they came from but unvaccinated individual or not. Now, because these are mostly babies that are, you know, the donated umbilical cords,

Starting point is 00:47:00 the stem cells of these babies, the babies have not been vaccinated yet, right? And so we feel pretty safe that there's no mRNA in these particular cells. I see. Because the donated umbilical cords in placentas, those babies that are just born have not been vaccinated. Right, yeah. Because, and I think that's, you know, when we talk about different. biologics like stem cells versus exosomes. I mean, exosomes are these nanosecretions, what they call them secretomes. They're secreted from stem cells. And what I find really fascinating.

Starting point is 00:47:36 See, this gets back to just the fascination with the human body and this $100 million pharmacy you're talking about. You can take stem cells, from my understanding, and you can bathe them in certain media and solicit a response and kind of target direct the response, meaning what kind of exosomes they secrete, and you can get exosomes targeted at skin regeneration or hairy growth or inflammation or tissue regeneration. And that to me is really fascinating because you're taking a live tissue product and your manipulating it in a way, you're exposing it to this media that causes it to secrete something. It's almost like you're going to the pharmacy and you're writing this script for, hey, I want to

Starting point is 00:48:29 something for collagen, elastin, fibrin, and the skin. Okay, we're going to put the stem cells in this media. It's going to create exosomes and that are more geared towards those kinds of growth factors. And, you know, like I say, high molecular weight, hyloronic acid and some of these other things are really beneficial for skin. And then you apply those topically. or to the scalp or what have you. So do you also use the exosome biologics? Yeah, we also use exosomes as well. What kind of applications?

Starting point is 00:48:57 So we use them in conjunction with our stem cells, and frankly, exosomes are less expensive. So if people, you know, the price tag on stem cells is too much, then we can use exosomes. But we're using it for many of the similar applications as stem cells as well. So what do you find that they're really proficient to treating?

Starting point is 00:49:14 Like, you know, skin regeneration, fine lines and wrinkles, hair, restoration? Great for skin care. You know, we do a lot of exosome injection into the scalp as well for hair regeneration. They're actually pretty helpful for joints as well. And so a lot of people like them as a substitute to stem cells or as an upgrade to PRP for joints as well. So I think one thing that everyone to know is that stem cells are going to affect differently depending on your own personal biology. I think you mentioned this earlier as well.

Starting point is 00:49:44 So if you're going to go in for stem cells and you're looking for hair regenerative, or skin, even exosomes, wrinkle reduction is really imperative, in my view, to get the rest of your biology in order. Yeah, I agree. This is why, you know, I like this sort of wheel or the sequence of events that you put people through because you're not starting them at the top. You're saying, let's get the root foundation done, make sure that we've got dietary, lifestyle, sleep, you know, whole foods, let's maybe clean up the blood, maybe one of these

Starting point is 00:50:17 filtration technologies, EBO2 or therapeutic plasm exchange. And if you want to continue on this journey, let's talk about how we can take a clean, healthy functioning biome and enhance it even, enhance it even further. That's exactly right. And that's what I love about this. It's like I feel like we're just scratching the surface of it. But in your practice at Next Health, what has been, as an overseeing physician, like, what's been your biggest aha moment that you see in your patients that are on this journey?

Starting point is 00:50:50 What do you find that most people have that they're surprised about? Or what are some of the outcomes that you find really, like, fascinating and exciting for them? When it comes to snacking, Masa is flipping the script on what real food should look like. Masa chips are crafted with grass-fed beef tallow, one of the healthiest fats on the planet. These chips are packed with essential vitamins like vitamin A, D, E, and vitamin Kills. too, all of which play a role in keeping your skin vibrant, your immune system strong, and your bone solid. But here's the real magic about Masa. Masa's corn goes through an ancient process called Nix-stimilization, which makes it way easier to digest, and it amps up its

Starting point is 00:51:30 nutrient profile. Plus, these chips are low in poofas, so you won't find any of the inflammatory seed oils that you find in most snacks, and instead, Masa uses pure Redmond sea salt, giving you a natural hit of minerals that keep your cells hydrated and your energy steady. So don't just snack. Reach for Masa. It's real food, real health without any of the junk. Grab a bag and I promise you'll feel the difference. Now let's get back to the Ultimate Human podcast.

Starting point is 00:51:56 The thing that surprises a lot of people is when we do total toxin testing. Oh, shocked me, man. Right? Yeah, we did yours too. Yeah. No, crazy. Yeah. I think that's when we discovered mold, right?

Starting point is 00:52:07 And we were like talking about it. Yeah. So I think. Aflotoxin A, aflatoxin B. Yeah. I had biz phenols, the, the microplastic. glyphosate. I had the April little A.

Starting point is 00:52:19 And, you know, I take really good care of myself. Yeah, one of the healthiest people I know, exactly. But we all. And so it means that, you know, the average populace that's unaware of these things. And I don't mean to seem that I'm not average. I'm very average. But the average populace is unaware of these. And I don't think the modern medical.

Starting point is 00:52:45 system even really looks at or even considers toxic. Not at all, right? So that's the biggest one. Yeah. Well, that was one of the biggest ones. I think, you know, there used to be three legs of the stool. There's nutrition, exercise, and sleep. Toxins is definitely the fourth leg of the stool, in my opinion.

Starting point is 00:53:02 I think it needs to be addressed. And it usually is now the root cause of many people's health issues. Because most people know, you know, how to eat better. They know they need to sleep. They know they need to work out and exercise. Almost, most people get that stuff right as they're going through their health journey if they're trying to fix something. But toxins are not considered.

Starting point is 00:53:24 And then when we measure them and we show people, their heavy metals are mold. It's a big surprise. But the good news is there's things you can do about it, right? And so a lot of what you talk about is reducing your exposure. That's the Pareto principle, right? That's the 20% of actions you could take that will get you 80% of the result is reduce your exposure. Right. And then on top of that, we can do some things to detoxify you like Igbo,

Starting point is 00:53:46 total plasma chain, but even sauna detoxifies even high-intensity training, glutathione. Right, IV therapy, right. Sauna, they don't have to be the really expensive treatments. You know, I think that has been a big aha moment for me too. Someone just forwarded me recently a post-mortem study, and I've only cursory read it, but it was looking at the post-mortem autopsies on MS patients. And at least in this study, 100% of these multiple sclerosis patients had parasites.

Starting point is 00:54:19 And, you know, sometimes when you think about lesions in the myelin sheath or on these nerves, you wonder, well, what could cause these legions? And all of us have parasites. I mean, sorry, guys, everybody listening to this podcast right now has parasites. You've got good ones and bad ones. Right. Right. You know, sometimes, you know, I think as our immune system gets less and less accurate and maybe, you know, more and more fatigued, these little things slip by, you know, circulating tumor cells slips by. In the DNA methylation process, you know, an old virus, like a mono virus starts to raise its ugly head as Epstein bar or you had chickenpox as a child and now you have shingles. And I think a lot of people don't realize that very often some of these ailments that we suffer from. are not things that are happening to us.

Starting point is 00:55:09 There are actually things that are happening within us. Absolutely. Right? And clinics like yours and I think functional medicine in general is really trying to strengthen the body back to the point where it can do its job on its own. Yeah. We haven't even talked about gut health yet. That's the other number two.

Starting point is 00:55:24 Yeah. Let's get into that one. Yeah. That's another. So we measure a serum zonulin level and also we do stool testing on most of our patients and especially if they're having any sort of weird symptomatology. Serum Zonulin. The serum zonulin is a marker of, it's actually the protein that holds our gut cells together,

Starting point is 00:55:44 our enterocytes. And when the enterocytes separate from each other, this protein gets released, it ends up in your bloodstream. And that's how you can know if someone has leaky gut or not. Yeah. So it's an incredibly useful biomarker of leaky gut. Yeah. And then you can actually follow the levels as you heal someone's gut as well.

Starting point is 00:56:00 Wow. And so we do this testing on our patients and it's a game change. So that level should be zero, theoretically, right? And I think it's fascinating that we only have a single cell layer that really truly is separating our inside environment from our outside environment. You know, I like to think of our gut as being actually outside of the body. Yes. It runs through us. Yeah.

Starting point is 00:56:21 It's the size of a football field. Yeah. But like a pipe, you know, it's contiguous with the side of your cheek, you know. And, you know, when you get internally, you only have a single cell layer really protecting you. Yeah. That's just incredible. So think about all the ways that that could go wrong. Absolutely.

Starting point is 00:56:40 And then all of the consequences it could cause. What does a gut healing protocol look like? Your gut has, you're right, one layer of enterocytes that you have, but you also have another layer of your microbiome. And your microbiome is also working hard to protect you from the outside environment. Keep toxins out and help you absorb nutrients, right? Now, if your microbiome is off and or your enteric, if your microbiome is off, your enterocytes then start separating and you get this leaky gut.

Starting point is 00:57:07 So a gut healing protocol involves, number one, getting your microbiome healthy again, right? And then number two, it involves giving your enterocytes what they need to regenerate themselves. So they need collagen, they need glutamine. Your enterocytes also need a break from substances that cause them to get inflamed. So they need a break from like gluten, some people are dairy as well. we do a lot of gluten sensitivity testing, dairy sensitivity testing, and we figure, I can't tell you the number of people we find that have gluten sensitivity. It's almost everybody.

Starting point is 00:57:42 It's kind of crazy. And so I think you give your gut a break from all the things that are damaging it. And then you give it some of the substrates and needs to heal. And you at the same time help your microbiome be healthy by taking in more fiber, by eating, you know, fermented foods. And then you can heal your gut over time. So bone broth is also extremely useful in helium, a lot of collagen. Yeah.

Starting point is 00:58:07 I do a lot of kettle and fire bone broth. I love kettle and fire. I love those guys too. Big shout out to Justin. What's up? But, you know, I'm a huge fan of that. I actually use it to get into and out of a fast. Yeah.

Starting point is 00:58:20 I find that just going cold turkey into a fast for me is a little bit harder. So, you know, the day before, I'll have a bone broth at noon. I'll have a bone broth at 6 o'clock at night. which really helps you get through that first 24 hours. And it's very satiating. Is this where your water fast when you're doing a long-term water fast? And then days two and three, when I'll do these fasting challenges, then we'll switch to just a mineralized water in the morning.

Starting point is 00:58:46 Maybe black coffee, if a lot of people can't just cold turkey on coffee. But black coffee or teas and then just with no cream or sugars or anything, obviously. And then easing into that last, that second and third day. And I find that that gets 70% of the people 100% of the way, right? Does that statistic even make sense? Did I make that up? It sounds like Ron Burgundy and Anchorman. So 60% of the time, it works every time.

Starting point is 00:59:18 But, you know, then it's just not too much too fast. Sure, sure. Because especially people that have poor insulin regulation because that drop in glucose and the drop in insulin just drives hunger and then you just binge eat in the middle of fast. Absolutely. Which is kind of the worst thing for.

Starting point is 00:59:42 But bone broths are excellent. What kind of gut healing protocols do you put most of your clients on? Is it probiotics? Do you ever use things like BPC 157? Absolutely. So oral BPC 157. We also do Ivy. glutamine as well and then those are the supplements to the actual you know

Starting point is 01:00:05 dietary program that we use as well and so we always tie them with a nutritionist that they need help as well to really modify their diet and then yeah those are those are the big highlights pretty much yeah and then and then also probiotics and also we use probiotics later on okay we try not to put too much into the gut at the same time. And then after we start seeing some healing and we try, we try to rebuild their microbiome. And this is also really important for people like on gLP ones, right? One of the main reasons we have this massive deficiency of gLP one in our population is because ultra-processed food has destroyed the bacteria that make gLP one, nor help us make our own

Starting point is 01:00:48 GLP one. Wow. Yeah. And so anytime we have someone on a GLP one, we also start them on probiotics to regenerate that bacteria that can help us make. our own GLP1. And so, you know, there's a lot of talk about being on GLP ones forever. Right. I don't think you need to be. You just have to use the time that you're on GLP ones to regenerate your bacteria in your gut that help you make the GLP1. Yeah. And you know, a lot of GLP1 responds to nutrient density. Absolutely. You know, so when we eat non-nutrient dense foods and in some of the studies that compared ultra-process diets to whole food diets, you see that, you know, Mark Hyman talks about

Starting point is 01:01:25 this all the time. You see that the people on ultra-processed foods have a tendency to dramatically overeat. Yes. And even on, even if given the same caloric density, one is a whole nutrient-dense food and one is a highly processed food that the highly processed participants, you know, had a tendency. I want to say it was either 500 or 800 extra calories a day, but those will add up fast. And they got hungry or faster. They also got hungrier more frequently. And they felt less satiated. And a lot of times are, you know, again, back to pharmacy, the pharmacy responds to nutrient density. If your brain is like, hey, we don't have, I don't have the raw materials I need, just get, put more in. Keep putting more in. And you keep shoveling more in. And it's, it's not ringing

Starting point is 01:02:10 the bell because you're not actually giving your body the, you know, the nutrients it needs, right. Nutrients it needs. And guess what's coming? So the big food companies have reengaged with the food scientist to make new chemicals and new foods that they can add and make their foods GLP1 resistant. Wow. Yes. So I just read some articles on this. And it's kind of in secrecy, but they've, some got leaked that the food companies have

Starting point is 01:02:41 been engaged to start making GLP1 resistant foods. So now you'll be on a GOP1 and you'll eat this processed food and you, the GOP1 won't work and you just keep eating it. So what I tell all of my patients is, look, it's insane. Yeah. I mean, this is a multi-billion dollar industry. That seems so intentionally sinister to me. Yeah.

Starting point is 01:03:01 Yeah. It's a multi-billion dollar industry. And these companies are going to, you know, do what they need to do to maintain their value, unfortunately. And so what I tell all my patients is, look, I understand you need this GLP one right now. But we're going to use this time to not just regenerate your gut bacteria, but to completely change your relationship with food. Yes. And I think that's key. Right.

Starting point is 01:03:23 Yeah. And then you, you, I imagine you titrate them up and you can titrate them off. Exactly. Which, you know, physicians in my previous clinic have done that with clients. I mean, I know that everybody's supposed to be on these for life. I mean, look, with the, you know, the American Pediatric Association has approved these down to, you know, age nine. Yeah. And I understand that there's a push to get that to age six.

Starting point is 01:03:47 I mean, can you imagine starting on a GLP1 when you're six years old? and still being on it when you're 50? It's crazy. That is mind-numbing to me. Yeah, I mean, it's just a massive subscription revenue for the companies that are making these GLP-1s. And we always have a goal with our patients. This is when we're going to get you off-GLP one,

Starting point is 01:04:05 but you have to have that clear off-boarding program. So it involves probiotics, nutrient-dense food, changing relationship with food, and a really good tool that we use on that, too, Gary, is a CGM. It really... Constant glucose monitor. Continuous glucose monitor, right? Oh, continuous glucose monitor, yeah.

Starting point is 01:04:21 so that they actually get an idea. You know, those are pretty fascinating because you start to see some of the magic in the human body. I remember when we started using those, too, I would get calls all the time. And so I would say, I woke up in the morning and I haven't even eaten. I started moving around on my blood sugar rose.

Starting point is 01:04:36 And I was like, good. That means your liver's working, you know. Means you're alive. Yeah, yeah, it means you're alive. But they're like, how's my blood sugar going up? I'm not even eating. I literally didn't even have water. And I was like, you know, we store glucose in the form of glycogen.

Starting point is 01:04:50 and obviously one of your liver's roles is to take this stored glucose, this glycogen, and then turn it back into glucose when you need it for fuel. So this gluconeogenic process is what you're seeing. And that's really amazing that you're seeing that, even in patients or clients that are on ketogenic diets, they'll see these same kind of weird rises in blood sugar. And I'm like, well, you know, your liver is actually converting it back in, to sugar and putting it in your blood.

Starting point is 01:05:22 Excuse me, that's how dependent we are on, on, and how crack addicted we are to sugar. Right. And back to your previous point, you know, I've read several articles on, you know, labs around the country that are specifically looking at ways to stimulate dopamine receptors and dopamine agonis in the body so that you get not just a flavor reward, you get this sort of emotional reward from food so they can get addicted to this dopamine cycle specifically designed to great addiction so you don't just like the food you're addicted to the food right um was the commercial can't eat just one i mean yeah why can't we just eat just one you

Starting point is 01:06:07 know some scientists figured out how they how they get us addicted to it um so what else is really exciting you about this field of longevity and and anti-aging bio optimization yes Yeah, so, you know, there's a couple of things. You had mentioned AI earlier. I think we are headed into this golden age where AI and quantum computing combined with just sheer computing power that we have right now, even before quantum computing, can be used to create digital cellular twins and also create new peptides. Digital cellular twins. Right. Not letting you off the hook on that.

Starting point is 01:06:43 Okay. Hell is a digital cellular twin. We will be able to replicate a cell within the brain of a computer and test models. molecules against it at scale, okay? And so when we can do this, and Stanford just did this. There was a news article yesterday. Stanford created a new GLP1 that has a specific response just to the hunger centers and doesn't have any response.

Starting point is 01:07:04 It doesn't create a nauseating response or some of the other side effects. Wow, or some of the paralytic bowel or, you know, gastropresis. Gastropresis, that was the word. And so they found this peptide molecule with a computer, AI-enabled computer program. And so we are going to develop these peptides, these molecules, rapid speed. And so, you know, that's my other thing is peptides. Peptides are the holy grill of medicine, I believe. These are natural drugs that our body makes and our $100 billion pharmaceutical inside

Starting point is 01:07:36 of us, right, that we've made for all of humanity. And so now we're going to discover more and more of these peptides by using computing power. And, you know, peptides are incredibly low cost to make. And, you know, you can get them from your compounding pharmacy, for example. And they have lots of great effects. And their side effects are also not as bad as regular pharmaceuticals. Right. So I'm really excited about peptide science expanding and also getting some political power behind it as well.

Starting point is 01:08:09 Yes. I'm really excited about that too. You know, the whole Maha movement, you know, this opportunity to affect public policy and come top down where you can actually really impact the masses. What would be really exciting is if we saw, you know, the healthcare model change. There's whole societies in the world, Singapore being one of them, Japan being another one, where they have actually engineered their health, their health system, and they are extending life expectancy. Yes.

Starting point is 01:08:39 Their life expectancy is continuing to go up by, now some of these countries, it was not by military force, but it was essentially by force because they would restrict people's ability to access to health care, but they would, they reward things like walking, they reward things like exercise, they reward things like lean diets. They don't have a, let's say a subsidy program that would cover things like, you know, high fructose scorn certain blatant foods, highly processed foods, cigarettes, you know, pay pens, alcohol, you know, and foods with high fructic corn, served sodas, things like that, they actually cover the kinds of foods that serve their cellular biology. And it's astounding. I'm going to dig more into this because I was fascinated

Starting point is 01:09:27 that there are governments out there that are looking at this crisis that don't have a health care system like ours that is profiting off of symptom maintenance and disease management. They don't have a profit center for type two diabetes. They don't have a profit center for cancer. They have a profit center for autoimmune conditions. They actually have the opposite. They're losing money as a government, right? Yeah, because here we socialize the expenses and we privatize the cost. Exactly. I mean, sorry, we socialize the cost and we privatize the profit. Right. You know, so the profit goes to private industry, but the cost goes to taxpayer, public, Medicare, Medicaid. All of us being into health insurance as well. It's crazy. Yeah. And so, you know, I think the incentives are totally

Starting point is 01:10:13 misaligned. And that's why our health care system costs is going up every single year. It's $3 trillion. A massive portion of our GDP goes to our health expenses because people make money off us being sick. Right. So true. And you look at other countries and like, we can't have this much sickness and illness. We have to fix it. We recognize ultra-process food is one of the number one enemies. We also recognize that probably close behind or equal to that is sedentary behavior. And so we're just going to legislate against that. And then people will get healthier. And we don't want to spend so much money on this stuff, you know?

Starting point is 01:10:47 Yeah, it's not about eliminating free choice. You know, it's about getting poisoned out of the food supply. Well, Dr. Darshan Shaw, this has been amazing. I absolutely want to have you back for a series on the podcast. I'm excited about the expansion of your Next Health franchise. Thank you. How does my audience find you? Yeah.

Starting point is 01:11:07 We'll find out more about it next time. Yeah, yeah. Next Help on the Internet. dash health.com. Okay. Me personally, I'm at social media at Darshan Shah-M-D. I have a website, Dr. Shaw.com. People can ask me questions on my website.

Starting point is 01:11:22 I try to respond to as many as possible or also social media. Yeah, yeah. And those are the main places to find me. And I'm happy to, you know, engage with the audience and help anyone along their journey. That's super. Well, I have a VIP group, a community that I'm building. And this is a community that I really pour myself into. We do, you know, live group Q&As, we do private podcasts, we do challenges.

Starting point is 01:11:46 We, um, I wrote an entire course. I put a course together on becoming the ultimate human and gave it into this community. So we're going to go into a private room now so they can ask you a couple of questions. If you're interested in becoming an ultimate human VIP, you can go over to theultimatehuman.com forward slash VIP. Sign up to be a VIP client. Um, and we will see you in that private room. otherwise I wind all my podcast down by asking my guests the same question and that is what does it

Starting point is 01:12:19 mean to you to be an ultimate human? I think for me being an ultimate human means to feel good in my own skin, have time for myself, time for my family, and time for my children and also to wake up every day with a positive outlook on life. Yeah. That's it. So amazing, man. So amazing. well guys um i'll vipes i'll see you over in the private podcast room and the rest of you guys make sure that you look in the show notes below follow dr darshan jaw and check out next health if you're interested in living forever and until next time that's just science

The Ultimate Human with Gary Brecka - 191. Dr. Darshan Shah: Stem Cells, Exosomes, and Plasma Exchange

There aren't comments yet for this episode. Click on any sentence in the transcript to leave a comment.