The Ultimate Human with Gary Brecka - 226. Gary Brecka Live at the Zenos Health Summit 2025 in Saudi Arabia: Nutrient Deficiencies and Genetic Methylation

Episode Date: December 11, 2025

Live at the Zenos Health Summit, I’ve presented on stage why 22 years of mortality research and 371 million data points prove that every disease pathway has its roots in the absence of oxygen and the specific raw materials your body needs to function. I’ve also exposed fallacies around genetically-inherited diseases, why lowering homocysteine is critical for cardiovascular health, and walked through Dana White’s transformation from brittle hypertensive on three blood pressure medications to canceling his heart ablation procedure entirely. The big data doesn’t lie, and neither does human physiology when you finally give what it needs. What would you do differently if you knew exactly what was shortening your life? CLICK HERE TO BECOME GARY’S VIP!: https://bit.ly/4ai0Xwg Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDCGENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show 03:34 Presence of Oxygen = Absence of Disease 13:15 The Methylation Pathway Chart 13:28 Fallacies on Genetically-Inherited Diseases 14:38 Attention “Overload” (not Deficit) Disorder 18:15 What Drives Anxiety (and Other Mental Illnesses)? 25:59 Inability to Break Down Homocysteine 27:39 Dana White’s Transformation 35:48 Catecholamines as Waking Neurotransmitters 38:22 The Gut-Brain Connection 43:14 The Genesis of Disease 46:01 Insulin Resistance 47:17 Importance of Hydrogen in the Human Body 55:56 Gary’s Morning Routine 57:55 Join the TUH VIP 1:02:49 Extended Life Expectancy = Absence of Processed Food 1:06:10 ADD & ADHD Causes and Treatments 1:15:15 Managing Oxygen 1:17:27 Should You Take NAD+? 1:21:07 Rapid Weight Loss is a Toxic Process The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

Because something runs in a family does not mean that it's genetic. In fact, the human genome is specifically designed to not pass on disease. You would actually have decreasing populace if the DNA was not excellent at removing mutations and keeping them from passing in generation to generation. It twists our mind to start unwinding some of these fallacies that we have accepted in modern medicine. But getting you to subscribe to the fact that you have a genetically inherited disease makes it very easy to get you to subscribe to a lifetime of medication. And we have built a multi-trillion dollar industry treating the expression of disease, not fixing the nutrient deficiency. And so we are

suffering because we are nutrient deficient and we are being treated for the outcome of those deficiencies. And if you want to see magic happen in human beings, you give their body the raw material that it needs to do its job. The best modalities harness the power that we have from Mother Nature, they bring it indoors and make it convenient. The best treatments restore our body's ability to protect and heal itself. The most important thing, and I think the most overlooked thing in all of bariatric medicine is... Thank you. Thank you. Wow, what a beautiful country, what beautiful people, what amazing hospitality. Thank you so much. Zenos Health Summit for putting on this event. So thank you for being so gracious in hosting us. My name is Gary Breka. I'm a human biologist, a biohacker, a researcher. For those of you not familiar with my background, for 22 years, I was a mortality researcher for large life insurance, which meant that if we got 10 years of medical records, on you and 10 years of demographic data, we could tell the insurance company how long you

had to live to the month. And I get a lot of flack for that because people say, well, you really can't predict life expectancy to the month, but I assure you that it is some of the most accurate science in the world. And I would always say during my career there, that if this database, with the 371 million lives that we had access to, this very particular database that knew the day the date, the time, the location, and the cause of death for 371 million lives, if that database could see the light of day, it would permanently change the face of humanity.

It would upend modern medicine in a way that would be catastrophic. Now, sadly, that database will never see the light of day, but the big data doesn't lie. And the sad thing about that career was that, even though I was allowed to have access to your medical records, I could see your demographic data, I could see your divorce decrees, I could see your trust in your entire estate plan, your bank accounts, your brokerage accounts. I was not allowed to have any contact with the patient. I was not allowed to have any contact even with the treating physician.

Even if I saw life-threatening drug interactions, I couldn't pick up the phone and warn that person. So I felt like I was sort of sitting behind a thick glass wall just watching blind people walk into traffic. And eventually one day, over a very specific case, I made a conscious decision and I said, why am I going to spend the rest of my life predicting death when I have so much knowledge on how to help people live healthier, happier, longer, more fulfilling lives? And so that's why I'm standing in front of you today. I left that industry 11 years ago, and I decided to dedicate the balance of my lifetime to helping people live healthier, happier, longer, more fulfilling lives.

So let's get to work. Every time I take the stage, I make this statement. I think it's one of the most important things that you will see for the balance of your lifetime in terms of determining how many more months you have left on Earth, your weight gain, your water retention, your focus and concentration, how well you regulate your hormones. You see the presence of oxygen is the absence of disease. I didn't expect that to be sparkling water that came on. on a lot harder than I anticipated. A little came out the nose.

So we are, the pipes are clear. We're good to go. And the reason why I say that is that in 22 years of research, we did not find a single disease ideological pathway, not one, that did not have its roots in the absence of oxygen or was not exacerbated by the absence of oxygen. And I'm going to give you some context on that in a second. I also make two bold promises every time I take the stage. The first one is that if you do what I ask you to do today,

statistically speaking, and this is very valid, it will add seven years not just to the lifespan, but to the health span of everyone in this room. You'll see that by the end of my talk, you'll see that the overarching theme is that we need to get back to believing more in what God gave us than what man makes us. And over the last 50 years, we have gravitated towards what Mayan makes us and further from what God gave us.

What's fascinating about the vast majority of the longevity, the anti-aging, the bio-optimization research is that, as I mentioned before, it's coming full circle, and we're getting back to the basics. The best modalities harness the power that we have from other nature. They bring it indoors and make it convenient. The best treatments restore our body's ability to protect and heal. itself. I believe deeply in the body's ability to deal itself because I have seen this happen hundreds of thousands of times. When we started our functional medicine clinic 11 years ago, we treated a quarter of a million patients differently than any other clinic at the time

was treating patients because we just restored their natural physiology. So I'm going to try to cut through a lot of the noise today and give you some basics on where do you start. What is the first test that you should do. How do you decide what to supplement with? Because the vast majority of us are supplementing for the sake of supplementing. We are not supplementing for deficiency. And if you want to see magic happen in human beings, you give their body the raw material that it needs to do its job. And so the second bold promise that I make is at the end of my talk, we're going to open it up to Q&A, and I will take any ailment, any ailment that you or loved one suffers from ADD, ADHD, OCD, manic depression, bipolar, hypothyroid,

autoimmune, and right here from this stage in front of a panel of other physicians, I will tell you what raw material is missing from their body that is causing the expression of that disease. You see, I talked about this last night at the YPO or two nights ago. We believe this in plant physiology, and we used to believe this in human physiology. You know, if you had a leaf rotting in any one of the palm trees out here, and you actually called a true arborist, a true botanist, out to look at that tree, they wouldn't even touch the leaf. You know what they would do?

They would courtest the soil. And they would say, you know, there's no nitrogen in this soil, and they would add nitrogen to the soil, and the leaf would heal. I can assure you human beings are no different. When you deprive the body of certain raw material, you get the expression of disease and we have built a multi-trillion dollar industry treating the expression of disease

not fixing the nutrient efficiency and there is scantly a disease ideological process that cannot be traced back to that very very first domino if you heard me speak earlier I said in human beings rarely if ever do multiple systems fail at the same time usually what happens is one thing goes wrong that causes everything. And so this is about getting back to that first domino.

And so I always start with this chart. There's a quiz on this later. So I want to take notes, commit this to memory. So I show you this chart for a reason. It's purposely confusing, right? This is a chart of what's called your methylation pathway. This is what's happening inside of 32 trillion cells in your body every second of every every minute, of every hour, of every day. You realize that of the 32 trillion cells that you have in your body, 300 billion cells that you woke up with yesterday would not be with you tomorrow.

Which means that about every 84 days, we turn over nearly every live cellular structure in the body. If I met you today and met you 84 days from today, you would be a completely different cellular human being. So why is it that we cannot heal from nearly everything that we face if we turn over all of the live cellular structures in the body in 84 days. The question is, what frequency are we sending those cells? What nutrition are we sending those cells?

How are we helping them to eliminate waste, repair, detoxify, and regenerate? Miracle cures are not miracle cures. They are the restoration of healthy cellular physiology. And inside of every single cell in your body, nearly every cell, you have your DNA. You have 32 trillion strands of this DNA. If it is broken in one cell, it is broken in every single cell in your body.

The DNA is not only responsible for replicating itself, it is responsible for every message that goes into the cell, called transcription, to give it a command to eliminate waste, to repair, to detoxify, to regenerate, and yet we never talk about what does that DNA need to do its job. Again, if it's broken in one cell, it's broken in every cell.

Do you know that of every strand of DNA in your body, only 60% of it is human DNA? 40% of every DNA strand in your body is viral. 40% of us is viral. And for your immune system, this is a walk in the park. Every time that DNA unwinds and rewinds and unzips and rezips and unzips and unzips and rezips, it silences these viruses, and it can do it for decades over and over. over and over again until it is deprived of certain raw material, and then it breaks down.

And as that expression of disease emerges, we start treating that expression of disease. And modern medicine has had a convenient way of developing a lot of fallacies around this so that we can get you to subscribe to lifetimes of medication. One of them is that the vast majority of disease is genetically inherited, which is patently false. You know, you can get paralysis of analysis by

chasing the genome right all of your predispositions to all of these diseases create all of this anxiety and the truth is rarely if ever do we pass disease from generation to generation in fact the human genome is specifically designed to not pass on disease you would actually have decreasing populace if the DNA was not excellent at removing mutations and keeping them from passing from generation to generation so if you have a crime condition. Let's say that you have high blood pressure, hypertension, and you go to your doctor, and they say, well, you know what? Yeah, I need still water, so it doesn't come out my nose again. Thank you. Always my wife to the rescue. Thank you, babe. If you go to your doctor and they diagnose

you with high blood pressure and they do a full cardiac workup and there's nothing wrong with your heart. Your EKG is normal. Your EEG is normal. Your heart and lung sounds are normal. All your advanced testing is normal and they can't find anything wrong with your heart. Right before they medicate your heart for a crime, they can't prove that it's committing, they're going to look at your genetic history. They're going to ask you for your family history and they're going to say, oh my goodness, your mom's brother has high blood pressure. Your father's brother has hypertension. You have familial hypertension. You have a genetically inherited disease. We do this for hypothyroid. We do this for type 2 diabetes. We do this for drug and alcohol

addiction, we do it for anxiety, for depression, for all kinds of conditions that run in families. Because something runs in a family does not mean that it's genetic. If you actually look your physician in the eye and said, well, if I have high blood pressure because my ancestor gave it to me, what gene did I inherit from my ancestor that caused this condition to exist? You see, that's when their face would go blank, because in the vast majority of cases, that gene does not exist.

And if that gene does not exist, that means that that disease does not exist. And so it twists our mind to start unwinding some of these fallacies that we have accepted in modern medicine. But getting you to subscribe to the fact that you have a genetically inherited disease makes it very easy to get you to subscribe to a lifetime of medication. So the fascinating thing about this chart, and the reason why I show you this chart, is not to prove to you how smart I am because I've committed that to memory. But it is actually to show you that if I were to blow this chart up, and I'm going to do this in a moment, nearly every person in this audience would recognize nearly every single thing on that chart. They are common vitamins, minerals, amino acids, and nutrients. And as you start to remove minerals, amino acids, vitamins, and nutrients from this very important chart called the methylation pathway chart, you begin to break down and express certain forms of disease. So, how many of you, if we're going to be honest here for a minute,

how many of you know someone or you actually suffer from attention deficit disorder? ADD, ADHD, I'm 40% of you. Wow. How about anxiety? How many of you know someone, okay, or you suffer from anxiety? How many of you are not going to raise your hand no matter what I say? One honest woman back there. Thank you.

Comp her ticket, please. Give her a refund. So if I were to just go into this chart for a moment and say, well, you know, because when I was very young, I was diagnosed with attention deficit disorder. Back then they called it hyperactivity and impulse control disorder. I was put into a special needs program at University of Maryland, taken out to the regular school of children. What they later found out was I was clinically photographic. So I had a clinical level of photographic recall at the time they thought maybe that was idiot savant or autism. And so I have an overdeveloped area for photographic recall.

I learned differently than other children. I recall voluminous amounts of information, so I can't read for pleasure, but I can read to record information. And I was diagnosed with attention deficit disorder. Thankfully, Ritalin and Adderall Vivianns weren't around by then, or I would have been heavily medicated. But if I were to go into this chart, and I was to say, well, if you have ADD or you have ADHD, I bet that no one has actually told you what it really is.

You see, in the human mind, we don't just create thought. We also break thought down. We actually dismantle thought. So the neurotransmitters that create thought are actually neutralized through a process called methylation, one carbon metabolism, and we actually break this thought down. So if you are creating thought at a faster rate than you break thought down, then this means you're opening windows faster than you.

you are closing them. So attention deficit disorder is actually not an attention deficit at all. It's the opposite. It's an attention overload disorder. It's too many windows open at the same time. And so if too many windows are opening at the same time, shouldn't the answer be, well, how do we close some of these windows? But that's not what we do.

In modern medicine, we say, well, if the mind is racing, let's put an amphetamine into the body to race the central nervous system to match the pace of the mind. Right? And this is exactly what Vyvans, Rital and Adderall do. They're an amphetamine. They race the central nervous system, improve the processing speed, so that it can match the pace of the mind. So this is like, this is what I said yesterday. It's likening, you know, getting a flat tire and getting out of your car and slashing your other three tires. Just create equilibrium. Right? So let's take the system that's not broken and let's break it to match the system that is.

So if attention deficit disorder isn't an overload, it's too many windows open at the same time, what causes these windows to open? Well, we have a set of neurotransmitters in our body. They're called catacolamines, the same neurotransmitters that are involved in a fight or flight response. I use the analogy that if any of you walked out this door this afternoon, and when you exited this door, somebody was standing in front of you with a knife. Very real threat. Your pupils would dilate. Your heart rate would increase. Your extremities would flood with blood. You would begin to have a fight or flight response. How did you begin to have a fight or flight response? You didn't put anything into your body. Nothing changed. What caused this response to happen? You had a rise in four neurotransmitters. They are called catacolamines, norophenephenephrine, epinephedron, dopamine. When these neurotransmitters rise, the very first feeling that you have is anxiousness. You begin to feel anxiousness. You begin to feel anxious. If they rise from a two to a four, you will start to feel mild anxiety.

You will begin to feel the presence of a fear without the presence of a fear. The genesis of anxiety does not come from your outside environment. It comes from your inside environment. So if you've ever suffered from anxiety, as so many of you graciously admitted, or you know someone who has suffered from anxiety, no one has told them that their anxiety is a rise in catecholamines, because we don't treat anxiety by reducing catecholamines. We treat anxiety by tranquilizing people with high catecholamines. And so if you've suffered from anxiety, you know that it has three common characteristics.

Number one, you've very likely had it in your entire lifetime, on and off throughout your life. You also know that it's very hard sometimes to point to the specific trigger that causes it. And if you can't point to the specific trigger that causes it, you don't have situational anxiety. This is not something that's happening to you. It's something that's happening within you. And the vast majority of people that try anti-anxiety medications will say they just make me feel like a zombie.

They don't actually fix the problem. So I have to choose between mood numbness or the sensation of anxiety. So the question is, where are these made? How does the body regulate them? You know, for decades, we developed a theory in depression called the serotonin hypothesis of depression. It was essentially that if you suffered from depression, that you had low serotonin. Serotonin is the main driver of mood. It is the main driver of emotion.

When this neurotransmitter is deficient, we express the disease or the outpath of depression. And so it's fascinating to me that we would define depression as low serotonin, and you would think that the treatment would be to raise serotonin. That's also not what we do. We take people that are low serotonin. We put them on something called an SSRI, a selective serotonin reuptake inhibitor, which essentially rations what little serotonin you have. So by its own definition, it doesn't raise serotonin.

So by its own definition, it doesn't end depression. I can't tell you how many people I have sat across from. Then I've asked them, they're suffering from depression. I say, well, how long have you been on an antidepressant? And they'll say, 12, 15 years. I'll go, great. When did you think it was going to kick in? Like, should we run this for like another two years just to see if

maybe 17 years is the right time frame? Because we're not fixing the deficiency. We're getting, I'm getting us back to the deficiency. So the question is, how is this? serotonin made in the body. Is this a laser pointer? Serotonin's made in the body by taking a simple amino acid called tryptophan and converting it into the neurotransmitter serotonin. So in the U.S. we're famous for falling asleep on Thanksgiving.

That's because Turkey has a lot of triptophan. So that amino acid gets them converted by a process called methylation into the neurotransmitter serotonin. This is governed by two genes. If you have a break in either one of these two genes, and I'll tell you what they are in a moment. But if you have a break in either one of these two genes, you have a poor capacity to convert tryptophan into serotonin. And if you are low in serotonin, you will express things like depression, mood numbness, the elevated moods, passion, elation, joy, arousal, libido start to leave the building. So do the lower tears of emotion? And all of a sudden,

you have a mood disorder because you have a deficiency in serotonin. Now what does travel in families is the poor ability to methylate serotonin. Not the disease depression, not to condition attention deficit disorder, not the expression of anxiety. There's no gene for anxiety. There is no gene for depression. There is no gene for attention deficit disorder, but they do travel in families. What's traveling in that family is the deficiency, the inability or the impaired ability to convert tryptophan to serotonin. Do you know what the body needs to convert? triptophan into serotonin. It needs the complex of B vitamins. It needs a very specific form of B12 called methylcobalamin, and it needs a very specific form of folate called methylfolate or folinic

acid. In the absence of those, you have impaired conversion. The consequence is just what we talked about. The same thing happens when we convert things like tyrosine and phenylalanine into the neurotransmitter dopamine. You know that there is an inherited gene mutation that impairs your ability to take these two amino acids and convert them into dopamine. What happens if you have a dopamine deficiency? You begin to engage in dopamine-seeking behavior. We had a saying in the mortality space, if I actually saw this gene mutation, and I saw that you were in drug and alcohol treatment center, or you had an addiction that you were struggling with, if I knew that you were unaware of that genetic

mutation, I would give you, in our model, a zero chance of conquering that addiction. In fact, if you know anything about addiction, you've ever been an addict or you've ever known a true addict, you know that addiction has a tendency to shift. It never really goes away. Drug addicts become alcoholics, alcoholics become workaholics, workaholics become workoutaholics. So this dopamine deficiency, which drives us to engage in dopamine seeking behavior is what drives addiction. We used to say that the absence of dopamine is the presence of addiction. I used to want to, I would just suffer because I'd want to pick up the phone and say, listen, when you come out of drug and alcohol addiction program, here's exactly what

you're going to take. You're going to take this methylated multivitamin. You're going to supplement with methyl folate. You're going to take something called Sam E, esedenosomythionine, and I want you to put this kind of B12 back into your body. This is going to fix the dopamine deficiency and you'll never have to worry about addiction again but I didn't have the ability to do that and that's why I'm I'm doing what I do today and so I saw this over and over and over again people being told that they inherited an addiction they inherited hypothyroid they inherited hypertension they inherited anxiety they inherited type 2 diabetes that these were actually things that were passed on to

them in the genome and never discussed the deficiency What happens when you put the raw material back into the human body and turn this cycle back on? In fact, I'll tell you another one, a big one, and this happened with Dana White. There's an interesting part of the methylation cycle where every person in this, I feel like I'm walking in front of all these cameras. So there's a cycle in our body. the human body is just so fascinating. You know, the more I study human physiology, the more I am certain that this was created by God,

it didn't happen by accident. You'll never convince me that two bacteria made love in a mud puddle a billion years ago and a lizard crawled out and eventually we had primates and then boom, we had human beings. It's too fascinating of a machine. But what's astounding is, you know that saying one man's trash is another man's treasure? This is exactly how the body works.

You put a raw material, a vitamin, a mineral, an amino acid, a protein, a carbohydrate of some kind into your body. And it starts here, and he uses that in his transaction, and his waist gets passed into the next transaction. And then that gets used, and that weights get passed on. And this is a sequence of things being converted. So homocysteine, which I'm going to explain here in a minute, which is an amino acid, gets broken down into something called methionine.

Now, methionine then goes up and it helps quiet the mind. When it's done quieting the mind, methionine gets converted into acedenicel methionine. And ascendinol methyanin converts into esedinosal homocysteine. It makes homocysteine again. It's this fascinating cycle of taking nutrients and passing them along so they can actually complete the sequence of transactions. So what happens if you have this amino acid in your blood, which all of you do? And you inherited, which is inherited, a poor ability to break down this amino acid.

it. Well, the first thing that happens is homocysteine, since you can't break it down, it rises. Well, homocysteine is really fascinating because in the right levels, it's amazing. As it rises, and it's cruising by the inside lining of your artery, it begins to irritate your artery. And if you irritate an artery, it will clamp down. And if you make the pipes smaller in a fixed system, the pressure goes up. And so, is it possible? that when the pipes narrow and the pressure goes up, you go see your doctor, and now you have been diagnosed with hypertension. And they look at the family history, your uncle had it,

and your mom's brother had it. So you have two uncles that had hypertension. You had two uncles that had genetically inherited hypertension. Or is it possible that you inherited a poor ability to methylate homocysteine? And you actually don't have a genetically inherited disease. You have an inability to break down a common nutrient in the human body. So this is what happened to Dana White. That's probably the case that I was made most famous for.

I sent my water down, but I don't know where I put it, and I don't want to drink yours. So I'll drink yours. Thank you. So when I met Dana White, Dana had, he was what was called a brittle hypertensive. He was on three blood pressure medications. In addition to that, he was also on a diuretic. They were using to get water out of his body. Unfortunately, he wasn't on a potassium sparing diuretic,

so he kept ending up in the emergency room with a potassium deficiency. And so he was on these three medications. They couldn't control his blood pressure. And when it got so bad, they decided that they were actually going to do a heart ablation. They were going to go in through the rib cage. They were going to burn the avidode of his heart. They were going to permanently disable the heart to try to lower the blood pressure. I had to pull 10 years of medical records on Dana and lay the record out in front of him

and say, Dana, in 10 years, you've never had an abnormal EKG, you've never had abnormal EEG, you've never had abnormal heart sounds, never had abnormal lung sounds. You had advanced cardiac testing done, imaging x-rays, cardiac cath, and a di-contrast study, all normal. There's nothing wrong with your heart. And so when we looked at his homocysteine level, and we looked at the fact that he had a gene mutation

that impaired his ability to convert homocysteine into methamphetamine into methionine, it was one of the highest homocysteine levels I had ever seen. Homo Sistine in the double digits is very scary. As it gets into the 20s, and for the first time I'd ever seen in the 30s, it is very, very scary. There's a lot of irritation going on in those arteries. And by the way, we have 63,000 miles of blood vessel in our body. 63,000 miles. Our heart is only responsible for circulating 30% of that blood.

Most of us think that the heart circulates all the blood in the body. it doesn't. It circulates 30% of the blood in the body. The other 70% of our circulation, which is microvascular, venules and capillaries, there is no pressure in that system. It is circulated by an activity called vasomotor. I always liken it to a snake swallowing a mouse, right? It's not the pressure pushing the mouse along. It's an actual vasomotor constriction that is moving that bolus of blood along. We never even examine the 70% of our circulation, that the heart doesn't do. We blame the cardiac system very often for crimes.

It's not committing. It doesn't take much arterial narrowing in 63,000 miles to drive pressure up. So I explained to Dana. I said, listen, I am not a physician. I'm not licensed to practice medicine. I cannot tell you to stop taking your medication. What it can tell you is that we're going to put you on an amino acid that your body is missing. It is called trimethylglycine, TMG.

I'm going to put you on this amino acid, and over time, your body is going to, for the first time in your adult lifetime, begin to metabolize this homocysteine. And as your homocysteine level falls, your vascular system should relax. And as the vascular system relaxes, the pressure should return to normal. I don't think that he believed me at the time.

He believes me now. But he didn't believe me at the time. So we started this treatment. I put him on it. I looked at his gene mutations, and I actually supplemented for each of those deficiencies, which was why I like genes of methylation. I think if you want to get paralysis,

of analysis, start doing down the genome pathway. The vast majority of that is just data, data that you cannot do anything with. Methylation genes are actionable. You cannot fix the gene, but you can supplement for its deficiency. And if you supplement for its deficiency and fix it in one cell,

you fix it in every cell in the human body. And so I put him on this trimethylicine, amongst other things, and over the next 21 weeks, his homocysteine started to fall. I'll never forget the day that he called me, and he said, Gary, something's really wrong. And I was like, you know, what's up? And he said, you know, every time I go into the gym for the last few days, as soon as I step on the treadmill or I pick up a weight, I get immediately lightheaded. I'm feeling like woozy lately.

I go, Dana, that's a great sign. And he goes, what the heck do you mean? I said, you know, when your blood pressure is high, your blood pressure medication will make it normal. As your blood pressure normalizes, it will actually make you hyposis dog. It will actually push your blood pressure down. This is the first sign that we need to talk to your cardiologist about titrating you off of your medication. And luckily, we found a physician that was willing to titrate him off. And at week 21, he was off all of his hypertensive medication.

This is going back two years. He is perfectly normal blood pressure now. He has not been medicated in two years. And his blood pressure returned to normal. And he canceled the heart ablation. I'll never forget the call that I got from the cardiac. at Cedar Sinai when Dana called to cancel this heart ablation. That was a very nasty one, wasn't it?

Maybe, yeah. We were actually dinner one night, and my phone started ringing. It was going, bz, bz, bz, and it was like this number from L.A. It was a 303 number. Finally, it had it called so many times, and I didn't answer it, and then they called again, and didn't answer it, called again. And so I picked up the phone, and I said, hello, and he said, Gary Breka, and I said, Yeah, and he said, this is Dr. Ram, Dan Delaya.

I had a cardiothoracic surgery, Cedar, Sinai, and Los Angeles. And I was like, oh, boy, here we go. And he said, listen, Gary, I don't know who you are. I don't know what you're doing, but I think that you're playing with people's lives. I don't believe in a thing that you're doing. And I still didn't even know who he was or why he was yelling at me. But, and I had on speakerphone, so Sage was listening. And he said, I've asked Mr. White to come out to Cedar and repeat his entire cardiothoracic

workup. And he said, so help me God, Gary, if it's not perfect, this will not be the last call you get from me. And he hung up the phone. I go, well, okay, that went well. So Dana did that. He went out to the cedar for three days, and he had a complete cardiothoracic workup. And to Dr. Dandelaya's credit, if you know Dr. Ram Dandelai is a phenomenal cardiac surgeon. We're actually best friends now.

We actually sit on a complicated case committee together, so things work out. But he went out, he did three-day work up. His cardiothorast exam was perfectly normal. And to Dr. Dandelius-Credit, he called me back and said, I owe you an apology. Would you humor me? Would you walk me through how you got this patient off? Brital hypertensive medication? And we talked about the homocysteine cycle and the damage to the endothelium

and microvascular circulation for three hours. And at the end of that call, we were best friends. And so very often I find, too, even in these case committees, how we intentionally try to overcomplicate things. But the truth is, getting back to the basics, vitamins, minerals, amino acids, nutrients. Does this body have the raw material that it needs to do its job? That should be our first question. That's where we should start.

And those genes, these are the genes right here. By the way, I don't offer a gene test in Saudi Arabia. I would love to, so I have nothing to sell you. These are the genes of methylation that we look at, and I can give you the specific reason behind every single one of these. But what's fascinating about these genes is that if I actually looked at your genetic profile, if you gave me those genes, and I did not know you at all, had never met you, I can tell you how do you go to sleep at night, I can tell you how you wake up in the morning,

I can tell you whether or not the souls of your feet or sore and achy when you get out of bed in the morning and walk to the bathroom to take your first feet. I can tell whether or not you wake up sore and achy like you had a workout the night before when you haven't. How soon libido will leave the building. Whether or not you lay down to go to sleep at night and as your environment quiets, your mind wakes up.

My way, how many of you fall into that category? You just lay there and ruminate at night. Why is it that when your environment quiets, your mind wakes up? because you do not break down catecholamines at the right rate. Catecholamines are waking neurotransmitters. If you have a break in a gene called comtee, catacole-o-methyl transferase, you are not able to regulate these neurotransmitters. It is, by the way, very easy to fix.

And so what happens is, as your environment quiets, your mind wakes up. And so you lay there and you think about the most ridiculous stuff right if i was actually going to your mind you'd be embarrassed right because it's not like life-changing earth-shattering you are not solving the world problems no you're not fixing humanity you're you're wondering if your belt matched your shoes that day if you got everything on your grocery list if you should have a dinner party with green dishes right this is the kind of thing that goes through your mind at night it is a wake-and-state from catacola means it's one of the first things i fix when i work with people as i put their catacola means

back into proper balance, they start sleeping like a baby. And by the way, if you fix sleep, that is the human superpower. That's the foundation of longevity. And so these people that have this same kind of wake and state are also the ones that generally suffer from anxiety. And they have that type of anxiety where you can't point to the specific trigger that causes it. It seemingly comes and goes without a trigger

because those catacolamines rise and fall without a trigger. you can go into a full-blown panic attack laying in your bed thinking about getting eaten by a shark. Not too many shark attacks in Saudi Arabia lately. I've read the news, right? But you could still think yourself into a panic attack. And so we are suffering because we are nutrient deficient and we are being treated for the outcome of those deficiencies.

Nearly every form of pathology and disease can be traced back to the initial breakdown. in cellular metabolism all cancer regardless of its form or its origin was at one time a healthy cell why do we believe that healthy cells can become metabolically sick but we don't believe that metabolically sick cells can become healthy as patently false and i can prove that to you and so and that goes back to the theory where i say generally one thing goes wrong that causes everything and so So I also, in working with thousands and thousands of clients that suffer from anxiety, I have never once, not once, in my entire career, met someone who suffers from anxiety,

who does not also have gut issues. But it's not the gut issues that you think. They suffer from either gas, bloating, diarrhea, constipation, irritability. Can I say diarrhea? I said it, so, okay. Gas, bloating, diarrhea, constipation, they have irritability, they have cramping. And what they do is they try to link it to what they last ate. But it's odd because they eat the same thing on Monday, and they're fine,

and then they eat the exact same thing on Wednesday, and they blow up like a tick. Well, right there, you know it's not an allergy, right? Allergies are consistent. Allergies are not transient, but you're doing food testing. You're doing allergy testing. You're doing food sensitivity testing, and you're down the road, and you clean up your diet, and you go on MAP's diet or some other diet, and it doesn't work. you still have the same symptoms

because you're actually chasing the byproduct, the outcome because the most important thing, and I think the most overlooked thing in all of bariatric medicine is not even the microbiome. The microbiome is extraordinarily important. We don't eat to feed ourselves. We eat to feed

our microbiome and it eats to feed us. But it's not the microbiome. It's not food allergies. It's not food sensitivities. It is the pace of the gut. You see the human intestinal tract is a 35 foot-long conveyor belt. We put contents on it at one end as they exit the stomach. 30 feet later, they exit the rectum. The pace of that conveyor belt is extraordinarily important.

If you walked into any factory in the world that worked on a conveyor belt system and you walked into that factory and you doubled the speed of the conveyor belt, the entire factory would break down. Nothing wrong with anything there. Conveyor belt's not broken. People working there are fine. The part that's on the conveyor belt is fine. Nothing wrong. You just change the speed of the conveyor belt, too fast diarrhea, to slow constipation, pause, cramping, bloating, and what we feel like menstrual cramps. And so, and if it pauses, by the way, for too long, you start to get the ituses, diverticulitis, ulcerative colitis. And eventually, if you develop tears and leaks in this single cell layer, you will have contents leaking

from the gut, leaky gut, going into areas of the body where they don't belong, that will call the immune system to that location. The immune system will show up. It will begin to wage a war. And then in the process of waging that war, it will manufacture an antibody. And now you are told that you have an autoimmune disease that for no reason at all, you woke up one day and your immune system decided to attack the colon. I'm sorry to tell you you have Crohn's.

Right? Again, rarely is that the case. In fact, I'm not going to go down the whole autoimmune bandwagon, but the best demonstration I can give you is this. In the human body, if this was a mold spore or a mycotoxin or a parasite or a virus or a pathogen of some kind, and this was a healthy cell, this does not hide like this. It hides like this. That's the most important distinction I can tell you.

because the immune system is hyper-vigilant. It wants to get to that. It's trying to protect you. In an effort to get to the villain, which is inside of a cell, when the immune system reaches a healthy cell but needs to attack a villain, it doesn't have permission to go inside. Do you know the immune system gains permission to enter a cell? Manufactures an antibody.

So what happens when heavy metals get embedded in the thyroid, and the immune system is called to the thyroid, and it lights up to thyroid tissue. You have Hashimoto's. What happens when the immune system gets called to the colon because you have a leaky gut and it's lit up against pathogens escaping the gut? You have Crohn's.

And we can go on and on. What happens when Helmuth parasites and sestoed nematodes corkscrew burrow into the myelin sheath and the immune system lights up at that location? You have multiple sclerosis. but you're told that you have an autoimmune disease for no reason at all you woke up one day and the immune system just decided to attack you well why did it decide to attack me did youopathic we don't know it just went haywire for no reason but we noticed that your mother-in-law

your your mom's sister had this maybe you inherited it maybe it's a familial condition your dad's brother had it too and there you go it's a familial condition so if we would just get back to that first domino, which is why I think methylation is so important. When we do not eliminate waste from the body, and I'm not talking about stool or urine, I'm talking about cellular waste, when cells do not have the ability to eliminate waste, repair, detoxify, and regenerate. This is the genesis of disease. You have a shift in cellular metabolism. Very often because those cells are nutrient deficient, not pathologic. Cancer is not something that happens to us. It's something that happens within us. And so this is why I am such a fan of methylation testing

and supplementing for deficiency. So if you want to know where to start and you want my opinion, you start by finding out the deficiency in your body. You fix the deficiency first, and then you can go down the road to supplementation. I am a huge fan of NED, Resveratrol, KU10, Oshuaganda, St. John's Ward, NMN, nicotinamide riboside. I'm a fan of all of it. But the fact is, you will get paralysis of analysis and supplement your way into a conundrum if you do not have a roadmap to what your body needs. And just like the example with the nitrogen missing from the soil, if you didn't find the nitrogen, nothing else matters. Everybody has their opinion on what's good for trees. We should add some water. Water is good for trees. Well, I've been watering it for three weeks. Nothing changed.

Sulfur is good for, let's add sulfur. What's that phosphorus? Phosphorus is amazing for plants. nitrogen. If you didn't find the nitrogen missing in the soil, nothing else mattered. And so that's why when I try to distill down, you know, where people should start, that's where I think you should start. What you should supplement with, let your body tell you what you're deficient in. If you have the MTHR gene mutation, which I won't tell you what the nickname is for that gene. I've already said diarrhea, so I won't say that. If you have that gene mutation, which, by the way, 46% of the population has. 46% of the people in this room

cannot take folic acid or folate, which you get from green leafy vegetables, and turn it into the form your body needs, which is called methylfolate. So you have a deficiency in methylfolate, and you have an excess of folic acid, which, by the way, folic acid, just for the record,

is an entirely man-made chemical. You cannot find folic acid anywhere on the surface of the earth. It does not exist naturally in nature. We make it in a laboratory. It didn't even exist until 1993. Somebody explained to me how a synthetic nutrient that we make in a laboratory that doesn't exist on the surface of the earth

is somehow essential for a healthy pregnancy. It's not. folic acid doesn't prevent neural tube defects. Methyl folate does. That stops as phase arrest in the DNA and prevents a neural tube defect. So, again, if we just get back to what God gave us, not what man makes us back to what god gave us we would find and we would advance the health and welfare of our society by leaps and bounds this is getting us back to that theory that i have of getting

back to the basics um so um insulin resistance is one of the big ones uh i'm not going to spend a lot of time on this this is one of the first dominoes to fall in the vast majority of of patients that i i don't have patients i'm not a physician clients that i see that have cardiovascular disease, hormone disruption, PCOS, endometriosis, positional with the static tachycardia syndrome, all of these conditions where we are, again, chasing the diagnosis and not the root,

insulin resistance is one of the big first dominoes to fall. In fact, now there is a whole theory in Alzheimer's called type 3 diabetes. Some physicians will tell you, and some neurologists will tell you that Alzheimer's is type 3 diabetes. it is insulin resistance in the brain. That is the genesis before the neurofibrillary tangles, before the amyloid placking. Those are outcomes of prolonged insulin resistance.

So I also am not a person that stands on stage and pushes products. I actually have nothing to sell you. I don't believe that there is any miracle supplement or miracle nutrient. However, I have been for the last three years, down the rabbit hole of hydrogen and why hydrogen is so important in the human body, hydrogen gas and the hydrogen ion. Again, without boring you to tears, I believe that the discovery of how hydrogen is acting in the human body and how we have had an increase, a decrease in hydrogen gas, both in the hydrophiles in our gut, in our gut, in our bloodstream, intracellular concentrations, over time because of depletion

in our soil, in our air, in our water, that hydrogen, which is the smallest, lightest element in the universe, which is also 10% of your body weight, is a miracle molecule in the human body. It is the only truly selective antioxidant that I'm aware of. We know that oxidative stress, right? causes ourselves to rust. What are things that cause us oxidative stress? Can I get nerdy for a second?

Can we, why don't we do this? Why don't we, before I go to the whiteboard, can we just actually take an obnoxiously deep breath together in through our nose? Just sit comfortably, face me. We are going to take the most obnoxious deep breath that you've ever taken in your life. We're going to pause at the top

and we're going to exhale through a straw, an imaginary straw. Ready? Hold and exhale through a straw. We're going to do that two more times. Ready? And exhale through a straw. Last one.

And exhale through a straw. So we developed a thing. called the oxidative theory of aging. And I would assume that a lot of the practitioners in here would agree with that. You agree that oxidation stress, free radical oxidation causes damage to our cells. The fascinating thing about oxidation is that without oxidation, none of us would be alive. Right? We actually don't want to suppress inflammation, oxidation, the cytokine response.

We actually do not want to suppress this too far. That is as dangerous as the oxidation itself. We have very important free radicals in the human body. I'll give you a couple of the big ones. We have something called superoxide. I always ask them to check these before, and they never do. On 100% of my talks, I get bad. What was the budget for this?

Did we? I mean, was this really where we had to save the money? Right here. We have superoxide. You don't need to know what that. is. Just know that we haven't in ourselves. It is excellent for human beings until there's too much. We have hydrogen peroxide. That is absolutely necessary for cellular function until there's too much. We have oxygen singlets. We know that oxygen is absolutely critical for human

survival and for cellular respiration and for our mitochondria until there's too much. Oxygen, an oxygen singly can be one of the most damaging things to your phospholipid bilayer. It can cause them to rust. And then we have a hydroxyl free radical. There is no known benefit in the human body for the hydroxyl free radical, so we want that at zero. And we could go on and on. But there are these different free radicals. And when something is a free radical, the counter to that is an antioxidant.

Blueberries are antioxidants. Does anyone know why they're antioxidants? what do they do they make some an antioxidant they donate electrons they what polyphenols but what do the polyphenols do that you're right they donate electrons and so something that is an antioxidant is donating electrons and reducing oxidation but if you oversuppress that you fall out of something called redux homeostasis In human beings, for us to thrive, we don't just need to suppress oxidation. We need something called redox homeostasis, a balance between oxidation and reduction. You can actually have that going on in the cell membrane and inside the cell at the same time.

And so what if there was a molecule that when you put it into the body was a selective antioxidant? It only suppressed oxidation down to neutrality and actually raised inflammation if it needed to, to neutrality. What if it targeted homeostasis? That's what hydrogen does. That's why hydrogen is so unique. It is a selective antioxidant. It uses the intelligence inside of your cell. If I go inside of a cell and I find the DNA, which we just talked about giving the DNA,

the raw material it needs to do its job. The DNA has the capacity to regulate these superoxide, dysmutase, oxygen singlets, oxygen-free radicals. There is a pathway into the DNA. I won't bore you to tears with this, called the NRF2 pathway.

If you take that pathway into the DNA, then the DNA will take over the suppression of oxidation and the increase of redox reactions. It will actually restore perfect balance. Hydrogen gas uses that pathway to access oxidation.

It is the only absolute selective antioxidant that you can put into the body in abundance, if even overabundance, with no risk of oversuppression. You can drink hydrogen gas. I take a tablet called H2 tab. It is an elemental magnesium tablet. You drop it into water. It efferveses into pure hydrogen gas.

and you drink that hydrogen gas while it is in the water, and the hydrogen will go to work. And I will link all of these studies. Hydrogen administration decreases the expression of various oxidative stress markers, such as myeloproxidase. In clinical studies, it reduced generalized markers of inflammation, high sensitivity C-reactive protein, reduces, it lowers inflammation and irritation in the liver

by restoring liver enzymes to normal. A 2001 study found that breathing high pressure, hydrogen could cure parasite-induced liver inflammation. This was a very, very interesting study that was done in the Journal of Experimental Gerontology because it was done in an older age population. They measured sit-stand ratios. They used markers of methylation to check their methylation cycle.

Every marker of short-term memory, recall, function, timing, improved by adding hydrogen water to their routine. and it reduced markers of oxidative stress, including improving insulin sensitivity. It doesn't act like other antioxidants. There is not a professional athlete I work with in the world, including one that lives here in this country, that is not drinking hydrogen water on a regular basis.

I am not a believer in the hydrogen water bottles. I am a believer in taking an elemental magnesium tablet, which is called H2 tab, and putting it into water and having it ever vests. In fact, I just did with my wife, reluctantly on her part. I was excited about it. We did 14 cities in 18 days. And I changed time zones every day for 14 days. And I'm talking Los Angeles to Sydney, to Melbourne. If you guys follow me, maybe you saw that journey. My sleep scores didn't drop below 88%. I used hydrogen

water to help me adjust to time zones and turn the lights on in the morning rather than stimulants. So if there were one thing that I was to say that I think should be in everybody's routine, it's hydrogen tablets. So I'm not going to bore you again with it. That's the one that I take. It's called H2 tab. It's elemental magnesium effervesce into hydrogen water. The reason why I use that exact tablet is that all 25 of the peer-reviewed studies that I will cite after this lecture are all using that tablet. They compare it to the Rice protocol in orthopedic injuries. It is a phenomenal, phenomenal compound.

I get asked a lot about what my morning routine is. That's my morning routine, if you want to know. It's very simple. This is what I use to turn the lights on in the morning. I take an amino acid supplement. I take a multivitamin. I take something called Baja Gold C salt, which has all 91 trace minerals. You would not believe the expression of mineral deficiency in human beings.

About 85% of us are clinically deficient in key minerals. I don't mean the big electrolytes, potassium, magnesium, sodium. I mean the minerals nobody talks about, molybdom, manganese, boron, zinc, silica. These can all be found in mineral salts. And so I believe that supplementing with a mineral salt is one of those, if there was a catch-all supplementing with a mineral salt is excellent. In fact, we were talking about this at lunch. You know, I spoke at a bone conference a while ago called Osteo-strong,

and fascinating to me how many even practitioners and functional medicine doctors still think that our bones are calcium. They're actually not calcium. They are calcium combined with something called phosphorus. We talked about this at lunch. Phosphorus and calcium combined to form something called hydroxyapit, and our bones are hydroxyapatite. Yes, you need to apply a load, load to the bone to start that bone remineralizing.

But if you are missing any one of 12 minerals, You cannot combine phosphorus and calcium into hydroxyapitite. The vast majority of people with osteopenia and osteoporosis are not calcium deficient. They are mineral deficient. In fact, if you go to cystic care living facilities all over the world, you will find elderly men and women, plethora of them, that have osteopenia and osteoporosis that have been on calcium supplements for 15 years. The answer is not excess calcium. The answer is the minerals the body needs to combine calcium and phosphorus.

So the last thing before I go to open it up for questions, and I hope you have a few minutes for questions, is I want to invite you guys to join my VIP community so we can keep this conversation going. This is a community that I am building of like-minded people, where I do live Q&As like this for hours every single month. I have put into that community mold detoxification guides, heavy metal detoxification guides. What is the best testing to find out if you have a lot? mold, metals, viruses, parasites. Where do you get that testing done? And then once you find out

the results, what do you do with them? I built a 10-month course called becoming the ultimate human. It starts with what you test with, what you supplement, how you eat, how do you go to sleep? What is the best sleep routine, proven sleep routine to improve your sleep scores? What is the best thing to do within 30 minutes of waking? What is the difference between whole food diet in a highly processed diet. So, and I gave you guys all think of 50% discount on that, but this is a community that

I'm building that I believe will actually change the world. We know that community and connection is so important and so missing from our society. So that is, I really hope that you guys will join that community and we can keep this dialogue going. Okay, so do

want to open it up for questions? Yes, sir. Why did I know you would have one sitting right there in the front? Thank you very much. First of all, I thank you. I've been following you, and I wrote it here a few things I want to say because I don't want to take too much of your time. It was meant to be gone. Basically, I don't listen to scholars to what they say until I look how they say it. And if they say it with humbleness and humility, then I know they are scientists. And you are one of them. So that's why I do. follow you. Oh, thank you so much. Socrates says... That is so kind of you. Socrates says it was meant to be, not for me to read what I wrote.

Socrates says there is only God, only God is wise. And the only thing is that I feel I'm wiser than others because I know, I don't know. And to be honest with you, I love what you say. Our body is much, much wiser than

No comparison. And the fact that we have to believe in God's creation more than man-made creation is the key element of success. I'm going to tell you macro, what's my diagnosis and my treatment and correct me anatomy. Yes. My diagnosis, number one, arrogance. We humans became so arrogant that we think that we have the medications to treat people. and I believe we're too arrogant.

We're underestimating the power of our self-healing, number one. Number two, greed. We're running by corporations and CEOs. They found that they can make more money out of our illness than our wellness. And those who think that they make money out of our wellness, especially pharmaceuticals, causing more damage than those who are intended to make us ill. Because number one cause of death is pharmaceuticals, medications.

So my diagnosis, my treatment of over 25 years of working with wellness. By the way, my hospital, I put the mission. In 1997, when I said mind, body, heart, and spirit, they used to laugh at me of the CEOs. What are you talking about? And I show you today how cause growth when he came. I convinced him he went back and he started the function medicine in Cleveland Clinic. My treatment is the following. Number one, that we have to just regain, help patients regain their balance, period, and allow the self-healing.

Yes. And number two, we have to help patients awaken their being, their value. I am worth it. Only with this, they have the right motivation to begin to follow the lifestyles. Number three, make the lifestyle so accessible to. them and somehow it has to be connected to them with the feedback that you have it sustainable. If we do that, I believe we can eradicate more than 80% of the diseases over us. Correct me, add to what I said.

Yeah, I'm first of all, I agree with everything that you're saying and I'll just be very quick on this so I can get to the next question. But you know, if we have this data, the data is already in, the big data already proves this, right? zone studies, there was no continuity between diet. So it's not keto, paleo, pescatarian, vegan, vegetarian, raw food, carnivore. That's not where we find life extension. We find life extension in the absence of processed foods.

That's what extended life in the blue zones. Sardinia had the highest meat, carbohydrate consumption in the world, extraordinarily long life expectancy. Singapore had the highest meat consumption per capita. Very long life expectancy. The Mediterranean, fatty fish, fatty oil. If you told your cardiologist, you were going to drink a liter of it. of olive oil a week, they tell you're going to die in two years, virtually no

cardiovascular disease. And then the French screwed up the whole model because they're smoking cigarettes, eating cheese, and drinking wine, and they're living to a hundred years old. So it was the absence of processed food. What was not exchangeable in any of the blue zones, not exchangeable, was a sense of community and purpose, which I likened to faith. I think faith, if you don't have it, you should find it, and a sense of community and purpose. These are true medicine. Yes. Faith is medicine. Connection is medicine. Nature is medicine. Those are facts. So I agree with you. Thank you so much, doctor, for a wonderful talk. I listen to everything. So here's

the thing. I'm a child psychiatrist and I'm also a functional psychiatry fellow and I work directly with Greenbelt. So my concern about this talk and I'm extremely distrously. disturb and concern. I saw so many people taking clips, and these clips will be forwarded to an ADHD patient or a mother of an ADHD child, and they'll come tomorrow and discontinue these medications. These medications are important. I do not believe of the absolute truth when it comes to science, because science change every day, the guidelines changes every day, but an information coming from somebody as influencer

as you are, it really hurt the other people. So the thing about this, I'm not going to go over a scientific aspect because I really disagree with it when it comes to SSRI and the pathways and the thing. There are so many logistic that goes behind it beyond what we just talked about. And the last thing that everybody is missing to mention, how much does that cost? The doctor is not your enemy. I am stuck with four hours clinics, seeing hundreds of patients in 10, 15 minutes. So I felt attacked as an allopathic medicine practitioner.

I felt I'm being trashed, and there is a huge mistrust between us and patient and population. I have no investment on giving medications. I don't want to give medication, but I have to stop a crisis. Each one of these intervention will cost thousands of dollars. You're talking about a family that needs to have at least six figures. Do you know how much does it cost? What costs thousands of dollars? So, genetic map.

How much does it taste, this dual analysis? $149 you do it once in your lifetime. $400? $149 you do it once in your lifetime. So, because I did that process, and I sent a lot of patients to do this. So the estimation for the first visit is about $1,500. Okay, that doesn't happen with me. I mean, you can get my genetic test online and comes to your house.

And then the gluten diet, for example, when we're talking about, we want to do restriction or we want to eat clean food. People don't eat McDonald's, I'm sorry, I don't want to mention a company. People don't eat 99 cents sandwich because they want to. They cannot afford whole food. I worked in Bellevue. Insurance doesn't cover. The system does not support.

So we're leaving people in a very tough spot. So this is not a medical crisis. This is a financial crisis that we cannot provide the best care to our patient. Thank you so much. I agree with that, too. So let me address your concern there. So let's take ADHD since we brought up ADHD. So attention deficit disorder, the vast majority of time when you diagnose someone with

attention deficit disorder, it's by act or observation. There's not you haven't diagnosed. There's not a modality you've found neuroinflammatory condition in the brain. there's not a blood biomarker that you're using. Okay, so the vast majority of time when we arrive at that diagnosis based on observation. So based on the outcome of patient behavior and other symptoms, you arrive at this diagnosis. The diagnosis itself is idiopathic. The source of the ADHD is of unknown origin.

And then the solution, let's say Vivan, Ritalin, Adderall. If you actually were to open the package insert of Vivin, Ritalin, or Adderall, in the first three lines of the third paragraph, it will open by saying the mechanism of action for this medication is unknown. So you have an unknown origin and an unknown mechanism of action trying to solve an unknown problem. That's the challenge. because in human physiology, these are absolutes.

If you actually deprive the body of serotonin, if you do not methylated catecholomines, if you actually have catecholomethylase, and you are a slow methylator of catecholamines, you will have symptoms of attention deficit disorder. But these are not unknown. This is not an idiopathic diagnosis. This is a hypercatecholamineic diagnosis.

a specific diagnosis. And then the treatment is not an unknown mechanism. The mechanism is actually known. Human physiology is absolute. If you lower catacola means you reduce the presence of fear, you reduce the presence of anxiety. So on the one hand, I empathize with you because you have to come up with an undone diagnosis, right, an idiopathic diagnosis, and then treat it with an unknown mechanism of action. So how can an unknown diagnosis be be treated with an unknown mechanism of action when the physiology is absolute. If you allow me. I'm a psychiatric geneticist, so this is my field and I know how we can't tackle this problem.

I'm a biohacker as myself, we published in nature, we published in many places. The thing is, in psychiatric genetics in general or complex genetics, it is not inherited as like from the parents directly. It's a burden of number of mutations that's associated. to the disease. So whatever you said about methylation, I agree portionally because there is mutations in those genes that cause the disease, that's for sure. However, it's not the only cause. We know that there is many genes associated with ADHD and others. We can measure them by burden analysis. And this is what I do. It's like looking into your genome and look

for the burden that can cause the disease to assess you as a preventive measure. If you're going to develop that, we will start cognitive therapy and others. What kind of therapy would you start if somebody had a predisposition to attention deficit disorder? Well, we can improve the education. We can improve the education. Let's be specific. What are you going to, somebody has a predisposition for attention deficit disorder. What do you do?

You educate them. I'm not in education. I'm talking to you as a biohacker, as a geneticist, where is the causality? The causality is in the genes. and we definitely know that. Okay, so now that you have the cause, how do you treat it? I'm not talking about the treatment now. I'm a scientist, so I'm talking your language.

The treatment is in the hand of educators, doctors, others. For my side, I can give you the predisposition of diseases, cancer, diapetus, hypertension. I can't predict that. Yes, if you have a family. These are predisposition. Yes. Once you have predisposition, what do you do? You can do many things.

If we're going to talk about mental illness, at least you would know that certain triggers, food, hormonal problems, whatever, you can already control yourself from the beginning. I'm against diagnosing psychiatry with genetics because it's like raising panics and raise harm more than benefit. And I'm against like diagnosing mental illness, though I do this. I do it genetically, bioinformatically. However, we cannot tell the people that everything in methylation. Methalation is portion of it. There's many things associated with the disease pathway.

We have disc gene, which is completely inherited. If there is a translocation between chromosome 1 and 11, you will get the disease inevitably. So I'm not going to give the patient or the individual the risk that raise... I think you and I are agreeing more than you think. My solution, my suggestion is, we start with methylation, and first, the first intention should be, does this body have the raw material that needs to do its job? That should be where we start.

We should start when someone has an autoimmune disease. We should say, what called the autoimmune disease? What called the immune system to this? But it's also, in other hand, it's like raising panic. If I knew that I'm going to develop schizophrenia from your test. I don't test for schizophrenia. The 12 genes that I test are all actionable genes. That's why we look at these genes.

Comtee also associated with schizophrenia and bipolar. Yes, Comtee is associated with schizophrenia and bipolar. I would sure like to know if I had a predisposition to schizophrenia and bipolar, but I had a gene that was actionable. And you're right. Comtee is also on a Dutch test for women's female hormones. It's overlooked by the vast majority of OBGYNs because Comtee sends estrogen down the E2 pathway. If you're not eliminating estrogen, you have an overabundance of estrogen.

And now a woman has excess estrogen, but no hormonal issues at all. She has an elimination problem. So the genes that we look at should be genes that are actionable. Otherwise, they are just data. If I'm flying from Saudi Arabia to Dubai, I don't care what the weather is in New York. It's good data, but it's not actionable. And so, as a psychiatrist or a psychotherapist, if you actually had a gene with a deficiency that caused an actionable nutrient deficiency,

why wouldn't we start there? And you also said we would give them diet and lifestyle changes. The diet and lifestyle changes that you're recommending are replacing the deficiency that is coming from that genetic mutation. So it is the nutrient. Why would dietary changes have an impact on mental health? Because they provide the nutrients for the body to behave normally. They drive one carbon metabolism.

So, if the results are negative, again, I'm not against medication. I'm against the over-medicalization of our society because we start with an unknown cause, idiopathic diagnosis, and we end with an unknown mechanism of action. Those are not two ways to create a solution. That is disease management and symptom maintenance. If we first said, does this body have? the raw material it needs to do its job. Put that raw material back. If you don't see a change, then by all means take the next step, but we should always start by restoring physiology. And those

are the genes to start with. Gary. We have a question over here. Over here? Yes, sir. Gary, thank you so much. I'm happy to continue that debate. But yeah.

Thank you so much for the time and the wisdom. You're welcome. Thank you for stopping us for three conscious breaths. As a fellow holistic health practitioner, I've learned the importance of the breath as it correlates to whole body health. I have a saying, breathe to achieve. Can you speak briefly as to how the breath can provide both fast and meaningful benefits towards our health? Breath is everything.

You know, it's really interesting. We are slowly becoming progressively more and more and more hypoxic. As we age, our respiratory rate gets more shallow. We rarely bleed with the lobes of our lungs. We breathe with the apex of our lungs. We are slowly suffocating. I'm not saying suffocating to death, but we are coming increasingly more hypoxic.

In fact, in the mortality space, We would place you on something called a hypoxic curve. We would actually look at how well your body managed oxygen. The more poorly you manage oxygen, the more quickly, the more fast you are accelerating towards the grave. The better you manage oxygen, the slower you are accelerating towards the grave. There were big comorbidity factors, things like anemia that would exacerbate many more conditions than just being low on blood oxygen, right? Anemic patients actually slept very poorly because their respiratory rate would drop, their blood oxygen would get too low and the brain would wake them up at night by pulsing cortisol.

This is why people that are the most exhausted sleep the worst. There was a statistic that I read, and I actually discussed it with Dr. Vonda right yesterday. She read the same statistic that after the age of 30, less than 5% of us will ever sprint again for the rest of our lives. I don't know if that's true. I don't know if there was a study run, but it means 95% of us after the age of 30 will never sprint again. We stop using our auxiliary muscles of respiration.

We stop using our diaphragm, which also circulates lymph. So breath is everything. I mean, I do breathwork every day. You see it on my eye chart. It's the way that I acclimate to a new time zone as I do breathwork in the morning. There are a lot of these simple practices that are just so overlooked. Fasting, which has been used by every religion on the surface of the earth for centuries. If you look at really the true physiology of fasting, it's essentially your own metabolic reset.

I'm not saying it's a cure-all for disease, but it does reset. the immune system. It decreases the amount of senescent cells. It bolsters our growth hormone and it improves our insulin sensitivity. If we had a pharmaceutical that would do all of those things, it would be the leading pharmaceutical in the world. We can get that. We can access through breathwork, through fasting. It's, again, just back to human physiology first. All right. So I agree with you. I don't know if I answer your question or just rambled for five minutes, but I agree with you. Yes, sir. How are we doing on time, guys? Hi.

Yeah, or you can just yell and I'll repeat it. Yeah, I would give the NAD if somebody was suffering from, you know, cold, the flu, or actually was trying to heal or repair the immune system. But what makes NED is something called nicotinamide riboside or nicotinic acid. It's actually the foundational B-Vitamin nutrient that we use to make NAD. And so we look at the deficiency in NAD without looking at the raw material deficiency that's used to make NED. It's just like about 70% of the time when someone comes in and I look at a hormone panel. And again, I'm not a physician.

But when you look at a hormone panel and you see that no one has no D-H-E-A, no vitamin D3, they don't have the raw material to make hormones. If I was magically suck the DHEA out of your bloodstream, your testosterone and free testosterone would drop. So does plethora of things like sexual hormone binding globulence. When we don't have the right levels of boron, a mineral, what happens is a protein in the blood rises called sex hormone binding protein. This sex hormone binding protein does exactly what its name sounds like. It binds to sex hormones and artificially lowers them. It essentially renders them neutral.

And so you see people with suppressed hormone function that actually are, mineral deficient, leading to proteins that bind to these hormones and artificially suppress them. When you restore the mineral balance, you put boron back into the body and lower the sex hormone binding globulent, the hormones return to normal. Very often, people that are hormone imbalanced are not hormone deficient. It's not an inability to produce the hormone. It's an absence of raw material that the body needs to make that hormone. So I'm saying we need to keep going back into the soil. If you can't draw the physiologic pathway from the expression of that condition, I'm low on energy, you need to draw that back into the root of the tree.

Why are you low on injury? Because I'm low on oxygen. What is oxygen carried in? Red blood cell and hemoglobin. Where is that made? Bone marrow. What stimulates the bone marrow to make red blood cells in hemogloin? The hormone testosterone. How is the hormone testosterone made? Dihydropy endrosterone. What is the level of dihydripy endosterone? What is the level of vitamin D3? Now you're reach the root. If you don't restore that physiologic pathway before you just start bringing things in the top, like hormone therapy, you haven't restored the raw material the body needs to do its job. And I'll take one more question. I'm not aware. I'm, I think the, I haven't seen a causal relationship. There may be a correlated relationship, but I haven't read a clinical

study myself, that there's a causal relationship between NAD and decreased risk of cancer. It makes sense metabolically, right, by giving the cell more nicotinide adenid dinucleotide, which actually helps oxygen utilization in the Krebs cycle. So that makes sense to me. But I'm unaware of a study that has a causal relationship between improving NAD and decreasing cancer. I have a question here. You have one?

Oh. Right here. Gary. Right here. You're yelling at me, but she's talking. I'll get to yours in a second. Yes, ma'am. Hi, we run a comprehensive weight loss program into our clinic,

and we do a lot of blood work. What I find is that the clients are having a very healthy weight loss throughout the weeks, supported by GLPs, peptides, IV therapy, and many other modalities. What I find is that their therapy level and homocysteine level rise throughout this process. And they're on GLP-1s? Yes.

Okay. GLP one or two, like I like Trezepatide better or the three-year. You like it better than somagletide or returituride? Yes, yes. But I find that, you know, is this because of the process of detoxification that's happening into their body? They're losing maybe a bit of a weight loss too quickly that their home-sisternable. Yeah, I mean, usually the...

And I do support their methylation throughout this process. Yeah. Rapid weight loss is a toxic process. I mean, I've had patients where you drop 200 pounds. I mean, remember, fat cells that you're born. with are the fat cells that you still have in adulthood. So they store not just, they're not just adipose tissue, they actually store toxins. And so rapid weight loss can put a lot of inflammatory compounds back into the bloodstream. What's interesting about the GOP-1s, and I'm a fan

of GOP-1, is that the body makes GLP-1, and we make GLP-1 largely in response to nutrient density. And so the question should be, not do I want to lose weight, but why am I fat? And if you're fat, because you've been bathing your cellular biology in a toxic soup, then bathing it in less of that toxic soup is not going to solve the problem. You may lose weight, right, because you've slowed gastric emptying and you've controlled the appetite. But the real question should be, what got me to the point where I am? And GLP-1s, actually, there's some fascinating research I'm reading on GLP-1s about actually having the opposite effect, lowering inflammation, improving neuro-inflammatory conditions, not in the full double doses.

every month over month, but in smaller doses. But I think even before we ask, you know, do you want to take a GOP-1, or do you need a GOP-1, is are we eating foods that properly release GLP-1? This is why you can eat three boxes of Oreos, but you can't eat your way through six avocados. It's too much nutrient density. Yes.

So, guys, thank you so much for your time. Thank you so much. I'm happy to continue this conversation after this. Yeah, thank you.