The Ultimate Human with Gary Brecka - 302. The Antibiotics That Reversed Alzheimer's Blood Marker - Dr. Richard Horowitz

Starting point is 00:00:00 42% of people, 55 years or older, expected to become demented. And yet, they spend $2.4 billion a year at the NIH, and no one has come up with a solution for it. When we realize that we spend $5 trillion a year on health care, we estimate that 85% of all chronic disease is preventable. We have to start looking at things like our chemical supply, our food supply, our water, our air, as micro-toxic environments that accumulate over time. And ultimately, what does it come down to? Inflammation in the brain. All chronic disease is driven by chronic inflammation. But where's the inflammation coming from?

Starting point is 00:00:33 Bacteria, viruses, parasites, fungi, microbiome issuans in the gut, vitamin mineral deficiencies, sleep disorders. We are waking up to infectious disease and toxicity as a root cause of some of the most prevalent chronic conditions that plague society of mankind. And I don't know why this happened in medicine, but they're like naming a disease and throwing trucks at it instead of getting to the underlying causes.

Starting point is 00:00:56 For folks that are watching this, like, where do we start with testing to just get a dashboard of what kind of villain we're after? For those of us who want to optimize our health, I discovered that... Hey guys, welcome back to the Ultimate Human Podcast. I'm your host, human biologist Gary Brecker. Today's episode is deeply personal for me. Like a lot of people my age, I've been watching my own mother's memory decline. I've been searching for answers, not just a diagnosis of it's aging.

Starting point is 00:01:36 My guest is Dr. Richard Horowitz, a board service. certified internist who's treated over 13,000 patients over 41 years, he is widely considered the closest thing that the chronic illness world has to a master diagnostician. Dr. Horowitz developed the MS-IDS model, 16 hidden factors from Lyme disease and Bartonella to mold and toxins that quietly drive everything from brain fog to Alzheimer's. He just published the first study showing this same model reversing P-Tal-217, the most sensitive Alzheimer's biomarker there is. using a nine-week protocol. If you or someone you love is dealing with unexplained chronic illness

Starting point is 00:02:15 or watching a parent decline like mine is, and being told there's nothing that can be done, this conversation is going to give you real, actionable hope. Let's get into it. Hey, guys, welcome back to the Ultimate Human Podcast. I'm your host, human biologist, Gary Brecker, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between.

Starting point is 00:02:35 And today is one of those in-between podcasts. It's going to be a very personal. journey for me and my family. I am so excited to have this guest on the podcast because his core competency fills a void that I have been trying to fill for over 10 years. You know, we talk about the body spontaneously just going wrong, Alzheimer's, dementia, early onset, cognitive decline, neuroinflammatory disorders, autism, ADD, ADHD, OCD, all of these chronic illnesses, autoimmune. And we just seem to have adopted the philosophy. that for whatever reason, the body has somehow spontaneously just begun to malfunction.

Starting point is 00:03:15 Nothing could be further from the truth. I've been talking about mold, mycotoxins, parasites, viruses, and heavy metals for the last 10 years, but it's really a paucity of expertise in the medical community. And our next guest, Dr. Richard Horowitz, is probably the closest thing that the chronic disease world has to a master diagnostician. And he is a monolithic giant. I'm excited to read his book. And welcome to the podcast. Thank you, it's great to be.

Starting point is 00:03:46 Dr. Horowitz. I'm so excited for this. And I, you know, when I was prepping for the podcast, I thought about the framing around this and all the different avenues that we could go down. But, you know, I'm on a very personal journey right now. Like a lot of people, my age, I'm 55 years old. I know I look 20, so don't like that shock you.

Starting point is 00:04:04 I was thinking 25. 25, okay. I'm just trapped in this gorgeous spot. but um you know like a lot of people my age um you know we're facing that decision about our parents you know is it time to bring them back in with us is it time to get them into some kind of assisted care memory care um you know a skilled nursing facility and it's a really hard decision and what really prompted this journey for me you know my parents live in tennessee and i'm in miami so i don't I wasn't seeing them that often.

Starting point is 00:04:38 My dad was calling me sort of more and more frequently about my mom repeating herself all the time and sort of forgetting things. And then the pattern tightened, meaning like her short-term memory got worse and worse and worse and seemed to cataclyly go off of a cliff. So this is a very personal journey for me around neuroinflammatory issues, Alzheimer's,

Starting point is 00:05:05 dementia, cognitive decline, because nothing's worse than losing a living loved one. And, you know, to be able to alleviate that pain for people would be one of the greatest gifts to humanity. And I feel like your work is heavily centered around that very problem that I'm dealing with right now. You know, it's interesting. When I started off as a board certified internist, I was not expecting to be a specialist in Lyme disease or Alzheimer's disease or autism or ADHD, none of these things. But interestingly enough, my spiritual teachers, I did my training in Belgium for seven years in French

Starting point is 00:05:40 at the Free University of Brussels. And I met Tibetan teachers. I was learning meditation there at the time. And I went to one of my spiritual teachers at the end of medical school and I said to him, Lamagenden, what's the most important thing you want me to know? I'm about to go out into the world as a doctor. And he said, Richard, the most important thing

Starting point is 00:05:57 is exchange yourself with others. Put yourself in people's shoes and do for them what you would want done for yourself. He said, if you do this, everything will go well. Well, interesting on my journey, so now it's 41 years in medicine, having seen over 13,000 people, I just turned 70, by the way. Yeah. And I just can't believe at this point that I've developed a model that is extremely

Starting point is 00:06:17 effective for not just chronic Lyme, but I just published the first study in the Journal of Alzheimer's Disease Reports. I saw that. Where we found that all 16 of the same factors, which I call MSIDS, multiple systemic infectious disease syndrome, the same 16 factors I've been looking at in chronic Lyme that have gotten people better are now published for Alzheimer's disease, and I just reversed Ptow 217, the most sensitive and specific Alzheimer's biomarker for the first time ever in the world using a nine-week oral antibiotic protocol, very short term. So I'm really curious to hear about your mom's case and

Starting point is 00:06:50 see how I can help because these are the kind of people I've helped all the time in my practice. Yeah, I would love it. In fact, you know, I'll document it. I'll put it transparently out on social media. I'm doing everything that I can do. with the knowledge that I have and the community that I have, which I will say has been very effective. You know, last 12 weeks has been incredible shift in my mother's journey. Hyperbarics, you know, red light therapy, lithium orate,

Starting point is 00:07:18 very, very, very clean diet, getting her glycemic profile down. She's been in that pre-diabetic range, like so many elderly men and women, for almost a decade, heavily insulin resistant, on statin medication for 20, five years now, heavy statin medication.

Starting point is 00:07:36 I mean, just the cessation of her cholesterol medication, I saw not an immediate, but I would say a noticeable return. And that's been talked about in the literature that sometimes statins, you do have to be careful with cognitive decline. Yeah, yeah. Because they also lower K-10 levels, and we know that mitochondrial dysfunction is one of the things in Alzheimer's disease, right in dementia, you have to watch for it.

Starting point is 00:07:59 Yeah. But what I find fascinating, you know, thankfully your work is now starting to receive the bright light that it deserves because HHS is very focused on Lyme. And I think that we are waking up to infectious disease and toxicity as a root cause of some of the most prevalent chronic conditions

Starting point is 00:08:21 that plague society of mankind. Mold, mycotoxins, parasites, viruses, heavy metals. And that once these things are in the body, You get these behavioral characteristics that mimic all kinds of chronic disease and we start trying to treat the chronic disease but nobody's going into the soil and saying, hey, what is the bug or the parasite

Starting point is 00:08:43 or the viral pathogen that lit this fire? And why are we going after the villain? You know, why are we only focused on amyloid plaques and neurofibrillary tangles and, you know, the byproduct of these conditions and not the genesis? You're absolutely 100% on target In fact, it is in the 16-point model,

Starting point is 00:09:03 it is infections and toxins that is always at the top of the list. So in this model that I describe an ending chronic illness, which has been the model I've developed over 41 years of 13,000 people. The infections that we've seen are not just one bacteria. It's not just Lyme disease. We find clemenade pneumonia. We find mycoplasma species. There are 18 different species of Bartonella,

Starting point is 00:09:23 which most doctors have never heard of. Maybe. Yes. And on top of that, we do see viral reactivation in people. Long COVID caused people to reactivate Epstein Barr and herpes virus six. But people get toxoplasmosis. A third of the world's population has toxo.

Starting point is 00:09:38 It's been associated with neurocognitive decline. Babesia, the parasite I see all the time, is associated with it. And finally, even fungal infections, they find fungus in the brains of people with Alzheimer's, not just in the gut. And it's interesting, most people know about Candida syndrome, right, if you're in the functional medicine space.

Starting point is 00:09:55 Right. They may not realize, though, that when you get leaky gut and intestinal hyperpermeability, and you've got Candida Oak growth in the grut, it's actually affecting your brain at the same point. They found fungus there. You combine these infections with toxins like mold.

Starting point is 00:10:09 90% of my patients are now showing positive for multiple mycotoxins. 90%? I don't want to gloss over that statement. 90% of your patients are showing positive results for mycotoxins. Okrotoxins, trichlothicines, glyotoxins, aflotoxins. They're showing up in all of these patients.

Starting point is 00:10:26 And we do find that when we detox the patients, and I've created some very simple protocols. Everything, by the way, I've tried to do over my career is oral, generic, easy to find, you know, solutions that anyone in the world can find this to do it. So I've detox thousands of people from mold. I was loaded with heavy metals myself. I had to take the amalgams out of my mouth

Starting point is 00:10:46 because I was so mercury toxic. And I was afraid of what it was going to do to my body from the free radical oxidative stress. So this is common at this point. So as you said earlier on, as we're getting older, Alzheimer's disease at this point, the NIH, these are figures from them, 42% of people, 55 years or older, expected to become demented. That is mind-numbing.

Starting point is 00:11:08 That is ridiculous. You would even remotely accept that. And yet, they spend $2.4 billion a year at the NIH, and no one has come up with a solution for it. So this article that I just published where there's 16 factors now gives people hope. It's like, hold on. I have cognitive decline. I have Alzheimer's, and we'll talk about the biomarkers.

Starting point is 00:11:25 I'd like to see your mom get. But there's things now that give people hope. Like, I don't just have to go on an anti-ameloid antibody like lachanamab dinanamab, which they just showed in a Cochran review is really not making much difference. Now, maybe if you addressed the infections like Lyme and Bartonella and pulled out the mold

Starting point is 00:11:44 and addressed all these other inflammatory factors, these drugs might actually be more effective. And that's something, and I know Secretary Kennedy is very interested, right? In looking at these chronic diseases, God bless them, because we needed someone to take a look at this. Yeah, you know, I think that, you know,

Starting point is 00:11:58 when we realize that we spend $5 trillion a year on health care, where the sickest, fatest, most disease-riddenation in the world, we estimate that 85% of all chronic disease is preventable. And, you know, we have to start looking at things like our chemical supply, our food, our food, our water, our air, as micro-toxic environments that accumulate over time. You know, I've sat in front of so many functional medicine doctors, and I think they would all agree that immunofatigue,

Starting point is 00:12:26 this slow progressive overwhelming of the immune system is one of the greatest hallmarks of aging, right? Just exhausting the immune system with low-grade fights going on on so many different fronts. Absolutely. And in fact, what I think most people don't know is that regarding your immune system, Lyme disease causes chronic variable immune deficiency

Starting point is 00:12:49 and 20% of my patients and 85% have subclass deficiencies. You then get Bartonella on top of Lyme, you'll see again even worse immune functioning. And what is Bartonella? So Bartonella is another bacterial infection. It's intracellular. It's showing up in 80 to 90% of my chronically ill patients at this point

Starting point is 00:13:05 who say, Doc, I'm tired, I'm achy, I have joint pain, muscle pain, I have brain fog, I have mood swings, I'm depressed, I anxious, I can't sleep. Bartonella is showing up in a large number, and most doctors don't even need to look for it. But when you combine Lyme and Bartonella, and then you get long COVID, which exhausts your T-Cast. cells. So now Lyme and Bart have exhausted your B cells from the bone marrow making antibodies.

Starting point is 00:13:28 Long COVID exhausted your T cells. And then you get gliotoxins on top of that from mycotoxins. Now you've poisoned your immune system with these bacterial infections. No wonder people are coming down with cancer. I'm coming down. Your immune system is being basically impacted by these infections and toxins. The toxins are affecting the microbiome of your gut. You need a healthy microbiome because most of your immune system is in the pyres patches of the gut. So all these toxins, if you're not supporting the microbiome with prebiotics and probiotics and even postbiotics, right, and eating a proper diet, how can you expect your immune system as you get older, right? I'm 70 or your mid-50s. How are we going to make it to 100 to make the oxygen in good health

Starting point is 00:14:08 and strong? Yeah. It's not, it's not going to be as easy if you don't look for these infections and toxins. I couldn't agree with you more. So to unpack all of this, because I want to try to keep this conversation narrow because there's so many, so many places that we could go. Let's just narrow in on lime because I think lime is the great undiscovered pandemic of the last century. I really do because the number of patients that we have seen with chronic Lyme infections that actually manifested first as EBV or cytomegalovirus or another form of infection. And if you were looking myopically at it, you said, okay, I wiped out the. the, this, you know, the EBV titers are back in normal range.

Starting point is 00:14:58 And symptoms don't improve. In fact, symptoms get worse. You know, progressive cognitive decline continues, maybe even accelerates. So, you know, for folks that are watching this, like where do we start with testing with panels to just get a dashboard of what kind of villain we're after? Sure.

Starting point is 00:15:18 So the first thing, most important thing to learn about Lyme is it's a clinical diagnosis. Okay. You don't make the diagnosis based on a blood test. It's by taking a proper clinical history. Now, interesting, you learn in med school that 90% of all diagnoses are based on pulling it out of a patient. They say the patient will diagnose themselves if you listen long. And it's true.

Starting point is 00:15:36 Right. And I can tell you after doing this for 41 years and 13,000, it is true. It is listening to the patient, but you have to know how to take a proper history. So I have on my website CanGet Better.com, a questionnaire that we validated in 1,600 people. we published this in 2017 in the International Journal of Medicine. We looked at three medical practices who did Lyme disease, healthy patients.

Starting point is 00:15:58 It turns out if you score over 63 on this questionnaire, it's two standard deviations above the mean. It's very high probability of Lyme. But specifically, there is one specific factor people need to know about Lyme that shows up in 95% which is migratory pain. If you have migratory muscle pain,

Starting point is 00:16:16 migratory joint pain, one day your knee hurts and two days later your shoulder hurts and three days later your ankle hurts, that is a hallmark symptom of Lyme as well as migratory neuropathy. Tingling, numbness, burning, stabbing sensations, even vibration.

Starting point is 00:16:31 If it migrates, the number one disease that does that is Lyme. There's no other disease that causes migratory neuropathy and we see neuropathy in 90 to 95% of our patients. Wow. So if you have a chronic fatiguing, musculoskeletal, cardiopulmonary, neuropsychiatric illness,

Starting point is 00:16:47 meaning you're tired, You're achy. You have brain fog. You can't fall asleep. You keep waking up the middle of the night. You're anxious and depressed, which is also chronic fatigue syndrome, fibromyalgia, long COVID, mold.

Starting point is 00:16:59 They all overlap the symptoms. The way you know it's Lyme clinically, is Lyme has good and bad days with the symptoms come and go. Not the case with viral infections causing chronic fatigue or fibro or mold that's in your body all of the time. Sort of consistent, not transient.

Starting point is 00:17:13 Correct. Okay. Also, you will see in women, especially around their menstrual cycle when the estrogen goes down, the bugs come out. So all of a sudden, women will tell you right before the menstrual cycle or during or right after,

Starting point is 00:17:26 all their Lyme symptoms get worse. So if you have a chronic fatiguing illness where you have good and bad days and it's right before your menstrual cycle, it gets worse with migratory pain. And then you start looking at Lyme-specific bands and also, let's say you took an antibiotic for urinary tract infection.

Starting point is 00:17:41 And you said, gee, my joint pain and my brain fog are better. Or you said, gee, I'm achy all over my body. and I can't think that's a Herksheimer reaction. You're killing off the bacteria. You're getting a cytokine storm. So reactions to antibiotics when you don't know you have lime is a clue for someone that Lyme might be there.

Starting point is 00:18:00 But there's a game I like playing called Lyme Bingo. And in this game, you get a good lab like Hygienics Labs in California that checks for nine different strains of Lyme. So why don't the regular blood tests work? Well, the two-tiered test by the CDC of an Eliza followed by a Western blood was done on one strain of Lyme disease, which is the B-31 laboratory strain. That is not the strain that is in the environment

Starting point is 00:18:24 that is making most people sick. So the tests are not going to be reliable. So we useigenics lab. If you get a 23 band, USP C, outer surface protein C, 31 band, outer surface protein A, 34 band, outer surface protein B, 39 band, very specific, or in 83-93. So you get one of these,

Starting point is 00:18:47 these bands with a chronic fatiguing muscular-iskeleton illness coming and going, good and bad days, migratory pain, better or worse with antibiotics, bingo, you have Lyme disease. And it's literally that simple. You score high on this questionnaire on can get better.com over 63,

Starting point is 00:19:04 migratory pain, even one band tells you you have been exposed. You do not use CDC criteria. CDC even had this on their website, by the way, a while back. Really? Yeah. Okay, so somebody that has a profile that fits the description that you just said.

Starting point is 00:19:21 On your website, does it say exactly what, can they get this test on the website? I assume this is Quest Laboratories. So I call this the, well, so the test itself, you'll get from hygienics, but I call this the Horowitz-EmSitz questionnaire, HMQ. The link for it is on can get better.com. You just download it from the site.

Starting point is 00:19:38 Okay. And the nice part about it is it's 38 questions, questions that you'll get in many chronic fatiguing illnesses. And it comes from my good friend Joe Boroscano. I just adjusted it and statistically validated it. But it's nice because when you go to your doctor, most doctors have 15 minutes for patients, right? If they're in an HMO model.

Starting point is 00:19:55 I was doing that kind of medicine when I first came out. These complex chronic glial patients are an average of 45 minutes or an hour that we have to take with them. But if you hand them this questionnaire, you can just look at the questionnaire and go, question one and 22, fevers, day sweats, night sweats, chills, flushing,

Starting point is 00:20:13 air hunger, I can't catch my breath in a cough. Those are symptoms of a parrot. a site called Babesia, which show up in 60 to 80% of my Lyme patients. So it's like having malaria on top of Lyme. So by just taking this questionnaire and bringing it to your doctor and checking migratory pain,

Starting point is 00:20:30 if you then get one of these bands back, you've got your diagnosis. It's not so difficult to diagnose, but this questionnaire really helps. Now, the treatment for Lyme, I think, is where you have so much divergence. Some treat it solely as a viral pathogen, ignoring, bacterial and parasitic co-infections.

Starting point is 00:20:50 Some will just look at lime titers and say, well, once we've done the doxycycline for 21 days and the lime tiders, you know, down, that's all she wrote. And then weeks, months later, patients start coming down with these types of patients. They don't, these types of symptoms, they don't link it back to that diagnosis. They think it's something new. And now you're off in the wrong correction. Yeah.

Starting point is 00:21:13 Listen, there's what I share on this podcast and then there's what I share. with my inner circle. If you've been following me for a while, you know how I hold nothing back here. But my VIP community, that's where the real magic happens. Picture this. You're struggling with energy crashes, brain fog, or just feeling like you're not operating at your peak, and you don't know where to get real answers. But here's what really sets this apart. You're not just getting my insights. When I have incredible guests on the podcast, VIP members get to submit questions for a private podcast segment. So that world-renowned expert we just interviewed, you get exclusive access to their knowledge, tailored to your specific situation. This section is under

Starting point is 00:21:51 the private podcast section in the Ultimate Human Community. And speaking of exclusive, you're getting my personal protocols. The exact tools I use for water fasting, gut optimization, and morning routines that have taken me decades to perfect. This isn't theory. This is what works in the real world. The community launches challenges throughout the year where you get direct access to me and my network of experts. It's like having a personal health advisory board for less than $100 a month. Your health is your wealth and this investment pays dividends for life. Join the VIP community at the Ultimate Human.com forward slash VIP and step into your ultimate potential. Now let's get back to the Ultimate Human podcast. So as you said, I think people need to really know this. 14.5% of

Starting point is 00:22:33 the world's population has been exposed to Lyme according to BMG Global Health, one of seven people. Wow. Now that's, I believe, probably, and you said it early, this is a pandemic, right? We're in a really bad problem with this disease. So here's the problem with it. About 10. 11 years ago, John Hopkins researchers, same time it came out of the University of New Haven with Eva Shoppies Group, Kim Lewis from Northeastern University, Stanford. They all came out with a very important study about Lyme disease, that it wasn't a normal bacteria. It's what's called a biofilm persistor bacteria.

Starting point is 00:23:04 So how does that differ? And this is, by the way, how I came up with an answer and what I believe is a cure for chronic Lyme. Correct. So what are biofilm persistia bacteria is tuberculosis and leprosy? So when I was doing HIV medicine back at Mount Sinai in my residency, a lot of people were coming in with mycobacteria amavium avium intracellulari.

Starting point is 00:23:23 They were coming with TB. This was right in the middle of the HIV epidemic. I got used to using tuberculosis drugs. And I always wanted to use these TB drugs in line, but I needed an excuse. So back in 2015, when John Hopkins said, hey, this is a biofilm persistor bacteria. And I went, oh, you don't just mean it persists.

Starting point is 00:23:41 You mean it persists like tuberculosis and leprosy. Now, how do they cure, leprosy, refampin and dapsone for a year. What did I do? I looked at the qualities of this drug called dapsone. So dapsone number one is anti-inflammatory. And as we're about to discuss during this podcast, every disease we're going to talk about today,

Starting point is 00:23:59 ADD, ADHD, autism spectrum disorder, Alzheimer's disease, allergies and asthma, autoimmune diseases, rheumatoid arthritis, chronic fatigue syndrome, fibromyalgia, cancer, cardiovascular disease, digestive disorders, irritable bowel, inflammatory bowel, hormonal disorders, mood disorders, pain, every one of them has all 16 inflammatory factors on the MSIDS model that I discovered in Lyme. How do I know?

Starting point is 00:24:25 Wow. I did a deep dive in the medical literature. It's all an ending chronic illness. But the point about this that's important to realize is by looking at the literature for Lyme disease and finding these 16 factors in discovering the Dapzone is number one anti-inflammatory because all the diseases I mentioned have all 16 factors and they're all driven by inflammation.

Starting point is 00:24:46 All chronic disease is driven by chronic inflammation. But where's the inflammation coming from? Bacteria, viruses, parasites, fungi, microbiomeissions in the gut. I'm coming from leaky gut and intestinal hyperpermeability with mass cell activation,

Starting point is 00:25:02 vitamin mineral deficiencies, sleep disorders. I call these the six rivers of inflammation driving an ocean of inflammation, which then causes mitochondrial dysfunction. Your hormones go off. You have potts disordernami and autonomic dysfunction. Your immune system doesn't work. You develop liver disease with fatty liver disease driving metabolic syndrome and liver inflammation, as well as pain syndromes and mood disorders. So in Lyme, when all these 16

Starting point is 00:25:27 factors were causing problems, when I looked at Dapsone and I said, hold on, this drug is anti-inflammatory, gets up into the central nervous system, so I might not need IV drugs. It hits autoimmunity. Lime causes autoimmune reactions in the body. Many people who came to me said, I have lupus because my antinuclear antibodies were positive. It was Lyme causing antinuclear antibodies. Or, Doc, I've been diagnosed with rheumatoid

Starting point is 00:25:50 arthritis because their rheumatoid factors were positive. Wow. But the marker for rheumatoid, CCP, cyclic sick, was negative. It was the Lyme causing autoimmune reactions, causing rheumatoid factors. Right? So the point being, Dapsone was anti-inflammatory,

Starting point is 00:26:05 got up into the CNS, affected autoimmunity, and it hit these biofilm persistor forms, white, while lowering down inflammation. So I decided to try it by adding in doxycycline or minocycline. I published my first study in 2016. It was a home run out of the park from the beginning.

Starting point is 00:26:22 Wow. My wife who had been sick for 25 years with chronic Lyme is now eight years in full remission since she did dapsone combination therapy. Wow. And I have many people in full remission from this protocol. So it can't just be that one silver bullet. No.

Starting point is 00:26:35 No, okay. The point I'm making here is when we believed before with Lyme that was chronically persistent because it had different forms of the bacteria, cell wall forms, amoxicillin and IV-Rocephine hits the cell wall form, or the bug goes inside the cells, the intracellular compartment. That's where doxycycline or xithromax or refampin or quinolones go. Or it had what's called cystic forms, L-form cell wall deficient forms that was flageal or plaquinole or metronidazol. We thought the bug would kept changing forms,

Starting point is 00:27:06 but until 2015, we didn't know it had biofilm persistor forms. And I have now published by 11th article in the medical journals, right? Ten of them are by me, one is by Tufts University, where they showed that giving refampin and dapsone cured lime in the animal model. We have a model in culture showing when you add dapsone to doxy or minnow and refampin and zithro, it lowers down these biofilm persistors. So we now have 11 published studies, including the last one on Alzheimer's disease, showing that Lyme can be a cause. Before it was a theory, it was hypothetical.

Starting point is 00:27:40 It was right, difference between association causation. We've now proven it. But the key was hitting the biofilm persistor forms of the bacteria. So, yes, you're going to hear people do IV therapies for years. I had a woman come in with one year of IV recephine nonstop. She stopped the drug and within one month she relapsed. I gave her Dapsone combination therapy. she went years in remission with a nine-week oral generic protocol.

Starting point is 00:28:06 So now it took me almost my whole clinical career to figure this out. This wasn't overnight. But it was almost like right in front of your face. It's just that, you know, when we get off on the wrong track and we think, wow, this is, this is morphing like a virus. You know, it's sort of COVID replicated into less infectious forms. Right. So when we start thinking that this replicatory cycle

Starting point is 00:28:32 where it's actually changing forms, you lost the genesis that no, it's always been there. It's just been, it has a biofilm that's protecting it, not only from some of these drugs, but also protecting it from detection. That is exactly it. That's the issue. Your immune system cannot recognize these bugs

Starting point is 00:28:49 when it's under the biofilms. That's exactly right. And in fact, why do you go to the dentists? So then you don't have the antibodies. Right. And why do you go to the dentist and take the plaque off your teeth? It's because,

Starting point is 00:28:57 Formonus ginger valis, which causes a cause of Alzheimer's, is under the biofilms on your teeth. That's why you have to have the plaque taken off. It's why we go to the dentist several times per year to do it. These biofilm infections, by the way, they've been around forever. Endocarditis of the heart. Candida infections of the gut is a biofilm infection.

Starting point is 00:29:14 Salmonella is a biofilm infection. Joint infections, right? When you get a joint replacement, these are biofilm infections that happen. So these biofilm infections have been around for a long time, but for Lyme, it was not known until about a decade ago. Wow.

Starting point is 00:29:28 And I tried putting in, by the way, for a randomized multi-center placebo trial, unfortunately, the NIH turned it down because of politics. And that's why I'm so happy that Senator Kennedy, you know, finally got in there. Secretary Kennedy got in. We need somebody at the helm who really is taking this seriously. Yeah, and I think he is taking it seriously. And, I mean, there are Lyme committees and subcommittees and there is a bright light being shown on this disease right now because, again, the end destination for a lot of

Starting point is 00:29:55 these chronic infections is our other neuropathologies. And now we're down the road of these neuropathologies and we missed the genesis of them. So can we, I want to stick with Lyme for a minute, and then I definitely want to get into Alzheimer's and cognitive decline because, you know, first of all, it's very vindicating for me to see that someone with your level of credentials and experience as is giving validity to the fact that a lot of these pathogenic invaders cause or mimic these chronic conditions. And I have long since held the belief that autoimmune is not idiopathic. It doesn't just spontaneously and randomly, the immune system just wakes up one day and

Starting point is 00:30:40 decides to attack you, whatever random tissue it's attacking. There is something is calling the immune system to that location, whether it's a virus or a parasite or mold or mycotoxin or, well, you know, Lyme. And having the diagnostics to give us that data so that we know who the villain is is the first step. No, it's crucial, so I'll take two autoimmune diseases. Let's take MS, multiple sclerosis and rheumatoid arthritis. Okay.

Starting point is 00:31:09 All 16 MSid factors that I had published in the literature for Lyme, and this is in my new book and the chronic illness, apply to MS. So I've had many patients come in with because MS is a demiliting disease, except the demyelination was not due to multiple sclerosis, which has now been shown to Epstein-Barr variants, but also, as you said, it's the immune system attacking from what?

Starting point is 00:31:30 Chlamydia pneumonia, right? By the way, MS was not in the Faroe Islands years ago until the British invaded the Faroe Islands. They knew that there was an infectious cause for MS from years ago. Rumatoid arthritis, there's a bacteria in your mouth called Agrabatobacter. If you have this bacteria, it tells,

Starting point is 00:31:48 your immune system to cause autoimmune reactions in the body, as well as having the wrong microbiome in your gut. You have the wrong previtellus species, from micudis, bifidobacterium. You don't have the right short-chain fatty acids in your gut. That's going to drive some of these autoimmune reactions. So in both MS and in rheumatoid arthritis, and I've had many patients come to me with these diagnoses, we got them off their metatrexateate. We stopped their ABC drugs for MS with Avinx, Betaserin, copaxone, steroids, because it wasn't true MS. It was lime and Bartonella and mold driving an autoimmune demilinating disease, but we also had a look at the microbiome. We still had to address the mitochondrial dysfunction. The hormones were thrown

Starting point is 00:32:29 off from the lime. So we still had a look at the 16 points. But once the bugs, the bacteria and the toxins, these two major factors which were driving autoimmunity, these people got tremendously better. Wow. So and even the people who have true autoimmune disease, you have a patient, and it's in my book, the patient had true rheumatoid arthritis, but methotrexate and steroids and a rava and emerald, they weren't working. Why? He came in with migratory pain. Well, migratory pain is the hallmark of lime.

Starting point is 00:32:56 Rumatoid arthritis is bilateral symmetric pain. We treated as lime and that all of a sudden his autoimmune drugs worked. They weren't working because he had bacteria and parasites like Babesia that were helping to drive this autoimmune inflammation in his body. It's no longer enough to name a disease and throw drugs at it.

Starting point is 00:33:16 You must unlayer every illness into these 16 points, especially for you and I, people that are healthy, right? I feel great, but I have to look at my own toxin levels. I have to make sure I don't have infections. I'm taking prebiotics and probing. I'm doing everything I can for these 16 points because I wanna live a long healthy life and optimize my health, but how can you optimize

Starting point is 00:33:37 if you've got infections and toxins and issues with your microbiome? Yeah. So you've gotta look at all of these factors if you wanna stay well, even if you're not, you know, a sick and chronic-agre in a preventative zone. So can we go through those 16?

Starting point is 00:33:49 Yeah, sure, let's do it. I think this would make a lot of sense because these are ways to shine bright lights on areas where we're not normally looking in a human body. So where do we start? Obviously, we start with the panel. Right, so let's start, so these 16 factors,

Starting point is 00:34:05 let's start with the six rivers of inflammation that cause an ocean of inflammation. Okay. As we said, all chronic disease we're seeing a real rise in chronic diseases, as you said. 86% of our healthcare costs, 70% of the deaths, 18% of the GDP in this country is from chronic illness,

Starting point is 00:34:20 and we don't have a model to address chronic illness. So it turns out when I did a dive into the medical literature, and I looked for ADD, autism, out, all 16 points. So what are the first six? Infections, there's four types. A, bacterial, B, viral, C, fungal, D, parasitic. So the bacteria that most of the time, in my patient population will cause problems,

Starting point is 00:34:42 are intracellular. They're inside the cells. That could be mycoplasma pneumonia, mycoplasma fermentans, chlamydia pneumonia, Borrelia beredorferi Lyme disease, other Borrelia species, 18 species of Bartonella.

Starting point is 00:34:56 So whenever these bacteria go into the intracellular compartment, they cause a huge amount of inflammation and you get chronic fatiguing, musculoskeletal, neuropsychiatric illness, right? So that's just one piece of the puzzle, especially when you've got these intracellular bacteria. But you can have strep,

Starting point is 00:35:12 also causing an autoimmune reaction with pans pandas, right? Not just causing a huge dramatic fever or glomelian nephritis, causing autoimmune reactions. And Lyme does the same thing with these autoimmune reactions, right? So that's one piece of the puzzle is bacteria. Bacteria. Viruses, CMV, Epstein-Barr, herpes virus six, but also HSV-1, HSV-2, parvovirus.

Starting point is 00:35:33 Many of these viruses are associated with Alzheimer's dementia. They're associated with autoimmune illness. Many diabetics, if you're not yet a type 1 diabetic, They show that early on in life, some of these viral infections will cause that autoimmune issue to start coming out. And most people have been exposed to these bacterian viruses. Now we've got parasites. Toxo is one third of the world's population.

Starting point is 00:35:55 And Babesia microte, Babesia duncanai, Babesia otocolii, these different species of parasites are now getting in, driving inflammatory reactions in the body. So if anyone's listening and says, I have day sweats. I have night sweats. I have shaking chills. I have air hunger, I can't sleep to catch my breath or a cough. Those are classic symptoms of babesiosis. We see this in a large percentage

Starting point is 00:36:17 of our chronically ill population. And then Candida, you know, I didn't really learn about Candida, except in immunosuppressed patients in med school. Candida syndrome, these people, let's say that you and I are well. But let's say you start falling asleep at 10 o'clock in the morning after breakfast or at 2.30 in the afternoon, you just take a dive.

Starting point is 00:36:35 That oftentimes is reactive hypoglycemia due to metabolic syndrome and too much insulin spikes, right? but Candida syndrome is associated with many of these people with hypoglycemia. So let's say people are optimizing their health. They're doing high intensity interval training. They're getting enough sleep. They've got a clean diet.

Starting point is 00:36:51 They're off sugar. But they're tired all the time. Many of these patients I found have candida overgrowth in their gut because they took courses of antibiotics and the doctors never gave them probiotics with prebiotics to get the right bacteria. I've had Candida syndrome. I know what it is.

Starting point is 00:37:07 My wife has had it. It causes the same symptoms as chronic Lyme, as long COVID, you'll see exactly the same symptom. Even with mold, it's fatigue, it's brain fog, it's muscle and joint pain. You treat with fluconazol or etrocanazol or a nystatin, all of a sudden,

Starting point is 00:37:23 their fatigue and brain fog is better. Wow. So all four bacteria, viruses, parasites, fungi, need to be looked at in this model, especially for people like us that are healthy, but want to stay strong and healthy as we get older. The second is toxins. As we've talked about, mold toxins,

Starting point is 00:37:40 they're showing up and up to 90% of my patients. With okra toxins, glial toxins, I'm in the mole capital of the world, right here in Miami. Miami, yes. And many other areas, you know, I think people, as the weather has changed and people have gotten flooding now from their basements, from changes in the climate.

Starting point is 00:37:55 A lot of people are getting mold. We had it in our house. It was a $150,000 renovation because they did not shut off the chimney flu and the water was coming down. We had black mold. Now, my wife and I never got sick, and I wondered, was it all these,

Starting point is 00:38:08 supplements that I'm taking all day long. I saw your supplement. Oh, I have something with me if you want to see. You know, and we're going to talk about these inflammatory pathways. Why I suggest, we'll get to this afterwards, for inflammatory pathways specifically that need to be either stimulated or blocked to stay healthy, because these infections and these toxins that are driving inflammation, there are certain underlying inflammatory pathways that we can work with nutraceuticals and diet that can kind of balance us and

Starting point is 00:38:35 keep it healthy. But so there's a test from real-time laboratory. in Texas. You take 2,000 milligrams of glutathione. You get into sauna, you sweat a little bit to mobilize the toxins. We're finding mold in a lot. And again, you can do serum mercury lead,

Starting point is 00:38:48 arson academy aluminum. But a lot of times you need to do like an EDTA challenge or a DMSA challenge to look for metals. Is it a 2,000 migs of glutathione? Is that oral? So you take it. I actually do it orally. Okay, take it.

Starting point is 00:39:01 Go in, what, a liter of fluid while you're in there, maybe mineral water or no, no fluids. No, no. So we make sure they drink an eight ounce glass a purified water every 15 minutes to hydrate. They take oral liposoma glutathione, get into sauna to sweat for 15, 20 minutes. We found the people that didn't take glutathione

Starting point is 00:39:17 that didn't sweat, you don't see the mold toxin show up as much. So, and by the way, we're just talking about a few toxins among, I know you know this, thousands that are getting into the body. Right, right. So they have now shown, the CDC is now shown between 150 and 200 toxins show up and everybody's blood and urine on a regular basis. The truth is it's thousands of toxins. all carcinogenic, affecting your hormone.

Starting point is 00:39:39 Why are women having a problem getting pregnant? Why are mems spurn count down by 66%? Yeah. It's from these environmental disrupting chemicals. It's going to another 1% a year and female fertility rates are going down. Male sperm counts are going down. I mean, these two are diverging.

Starting point is 00:39:53 These toxins are affecting the hormone receptors in the body, which is why people were having problems with fertility. Right? So, and they're blocking your hormone. So your hormone testing looks normal for your thyroid and your adrenals, but you're getting blockage for these hormone receptor sites.

Starting point is 00:40:07 by the environmental toxins. So infections and toxins are the first two most important. But number three and four is the microbiome of your gut, followed by leaky gut, intestinal hyperpermeability, and mass cell activation. So every disease I looked at, from autism, ADHD, Alzheimer's, cancer, cardiovascular disease, chronic fatigue, fibro, mood disorders,

Starting point is 00:40:27 it was an abnormal microbiome of the gut with the gut brain axis that was driving inflammation. So if you've taken any courses of antibiotics without the right probiotics, and even if you haven't, these environmental toxins are destroying the microbiomes of people's gut.

Starting point is 00:40:44 So I take four different probiotics a day. Really? With a prebiotic from orthomolecular called MGP fiber. It's got soluble and insoluble fiber, so it's taking some of those toxins and the liver entropatic circulation. And I'm even taking a postbiotic called PDC activate

Starting point is 00:41:00 with a type of a strain of a bacteria that drives my immune system to get my natural killer cells and T cells more activated for viruses. So the microbiome is extremely important. If you don't have enough short chain fatty acids in from these bacteria, you're gonna get inflammation in your body.

Starting point is 00:41:18 And I had leaky gut. Do you know, I had asthma and allergies early in my life and did not know that it had mass cell activation and histamine sensitivity. I was allergic to over 50 to 60 foods. Wow. I healed my gut, got off these histamine foods. I have no more asthma.

Starting point is 00:41:33 My allergies are much better. So did I have to take asthma meds for the rest of my life? No, I needed to get to the underlying causes of where the allergies and asthma from. Gosh, asthma is such a pandemic. So three and four is your microbiome, leaky gut. Five is vitamin mineral deficiencies.

Starting point is 00:41:47 Now, most people will check B12, but they may not know there's a marker of B12 deficiency called methamelonic acid. We see a lot of people with a cult B12 deficiency. Or they check their minerals, but they don't know that 99% of their minerals are inside the red blood cells. So you need magnesium for 300 detox of

Starting point is 00:42:07 enzyme in your body. So you get all these toxins in. If you don't have enough magnesium, you can't get rid of them. And then you're getting asthma, irritable bowel, and back spasms. What are these all have in common? Magnesium deficiency, right?

Starting point is 00:42:20 So it's not a question of taking Roaxin for your back spasm or asthma sprays. You need to look for magnesium deficiency. If you don't have copper, you need it for superoxide dismutase to deal with all your free radical oxidative stress. If you don't have zinc, you have an aldehyde problem in your body

Starting point is 00:42:35 from your phase one liver detox. but you have to check red blood cell zinc, red blood cell magnesium, red blood cell copy. We find up to 20% of these chronically ill patients are all mineral deficient. Now are these intracellular nutrient assays? There's not serum blood studies, like you would get a normal lab corp that says your magnesium.

Starting point is 00:42:55 No, those are your lab core and quest. Lab core and quest, but they're not serum blood tests, they're intracellular. We do serum and we do red blood cell. Okay, but it's true standard labs. So it's, okay. Yeah, bio reference, Quest, lab corps. So you could just add that diagnostic code and just do RBC, RBC hemoglobin.

Starting point is 00:43:12 Absolutely. And even R79.9 in this ICD9 code is like, you know, laboratory abnormality. Right. We've never had patients had problems getting insurance to cover these tests. Okay. So vitamin mirrors and the sixth is insomnia, sleep disorders. Now here's the problem with sleep. All 16 MSSIDs factors that we're talking about underlying insomnia, but Lyme causes people to not fall asleep, keep waking up in the middle of the night. so does Bartonella. But you might have a young thin woman who might say, I have sleep apnea. It's like 10% of young thin women

Starting point is 00:43:42 even have obstructive sleep apnea. Or men as they get older, have benign prostatic hypertrophy. Or mood disorders, depression, anxiety, are keeping people up at night. If you have insomnia, you get an elevation in cytokines like intralucin 6

Starting point is 00:43:56 and that throws off your whole system. So if you don't get to sleep, right, nothing else you're doing, right? You're trying to pull these nails. Nothing is going to work. So those are the six main factors. It's infections, toxins, microbiome issues, leaky gut with mass cell activation, vitamin mineral deficiencies, and sleep disorders.

Starting point is 00:44:14 Wow. Right? So those are the six main factors. So now you've got all this inflammation coming from different sources. It has downstream effects. What is the downstream? Number one is mitochondrial dysfunction. Yeah, the genesis of everything. I mean, you know this well because I know your work.

Starting point is 00:44:28 That's the genesis of aging. The mitochondria is the powerhouse of the cell. If you have mitochondrial dysfunction, your brain cells don't. work. The heart doesn't work after heart attacks. It causes liver dysfunction, one non-alcoholic fatty liver disease. Same thing with Crohn. You need functioning mitochondria for every cell and every, you know, organ in your body. Yes.

Starting point is 00:44:47 But there's nothing surrounding the mitochondria like your DNA of histones to protect it from the free radicals. There's nothing protecting your mitochondria. So everyone is doing mitochondrial regeneration, which I do daily, ATP 360 from research nutritionals, CO-Q10, acetyl-carnatine. people will take certain probiotics to get urolithin in A to get higher. So I do ergothyanine from mitoprime from zymogen. I'm doing this daily.

Starting point is 00:45:12 But if you're doing mitochondrial generation and you still have free radicals of tracking your mitochondria, you might say, well, why am I still tired if I'm doing mitochondrial generation? I'm getting to sleep and I'm exercising because the infections and the toxins and the microbiome had not been adequately addressed, so your mitochondria is still under stress.

Starting point is 00:45:31 And then the hormone, get thrown off because this inflammation affects the hypothalamic, pituitary axis. So men in their 20s come in with low testosterone. And they're coming in on beta HCG shots and creams, and I'm thinking, hold on, nobody figured out why a 25-year-old male has low testosterone. Lime is the number one cause of low testosterone

Starting point is 00:45:51 in my population. And how do we get it back up? We give them clomophane and arimidex. I give them a drug that they use for women in pregnancy, which stimulates lutenizing hormone in the brain, tells the testicles to make testosterone, no shots, no creams. We get the pituitary to kind of jumpstart again.

Starting point is 00:46:10 And then we give them a remodex and astrosol to stop the testosterone from aerotizing to estrogen. I get the testosterone from 100 to 600 with a low dose of these drugs that are all generic, right, easy to get from your doctor. Yeah, our clinical director's done that for young males for years. I mean, because you know, putting these young men

Starting point is 00:46:28 on hormone replacement therapy and starting them on testosterone injections in their early 20s is my numbing. I mean, that's... It shrinks the testicles. It shrinks the testicles, low as the sperm count. Right, I mean, you're not gonna have children easily early. So you have to get to the, and I don't know why this happened in medicine, but they're like naming a disease and throwing trucks at it instead of getting to the underlying causes.

Starting point is 00:46:48 And a lot of doctors and patients out there don't realize that is a very common cause, but also the adrenal cland. This may sound surprising to you, but 99% of my patients have low adrenal function. Wow. Everyone on a DHA-C-Cortisol salivary test, not blood, salivary testing, we find phase one, phase two, phase three. Cortisol, aldosterone, like all of the- Well, especially, aldosterone's more with the blood pressure control, but D-H-E-A-Cortisol thrown off in most

Starting point is 00:47:14 of this population because they're under stress. So let's say you're optimizing your health, you're exercising, you're taking mitochondrial supplements, you're getting to sleep. A lot of people have never checked their adrenals through a salivary test, and we're finding in most, even in long COVID, All 16 MSSID factors we're talking about today,

Starting point is 00:47:32 and it's all in end of chronic illness. It's the last chapter of my book, VAS for viruses. All 16 factors are affected in long COVID. I published it two years ago in the journal Microbiorganism. Most doctors don't know that adrenal support is needed for these people with long COVID. It's not just Epstein-Barrin-H-V-6 reactivation, right? And your serotonin goes down

Starting point is 00:47:52 because the bifidobacterium, your gut was thrown off. So now they're giving him fluvoxamine, this drug that raises your serotonin, but why? Because it threw off your microbiome from the COVID, affecting your bifido. But they're not going backwards to look at the biochemistry and the biology.

Starting point is 00:48:07 It's a systems biology problem. So we've got mitochondria hormones. Then we've got the immune system thrown off by these toxins, as we said, in infections, or autoimmunity. Lyme causes ANAs, rheumatoid factors, antithirogly. ANAs, like just a high anti-nuclear antibody.

Starting point is 00:48:25 One of my favorite biohacks outside of breathwork, by far is mineral salts, Baja gold sea salt. It's got all of the trace minerals that the body needs. You know, most of us are not just protein deficient, meaning amino acid deficient or fatty acid deficient. We are mineral deficient. So a quarter teaspoon of this in water, first thing in the morning will make sure that you get all of the essential minerals that you need. It tastes amazing. In fact, I made a steak today. I actually made a grass fed steak with grass fed butter and I put just mushrooms and a little bit of rosemary and I sprinkled Baja Gold C salt all over the top.

Starting point is 00:48:56 Try it. It'll be your new favorite for cooking, too. It's the cheapest and one of my favorite biohacks. I don't know. A $15 or $20 bag of this will probably last you five years. It's literally the world's best biohacking secret. Now let's get back to the ultimate human podcast. So antinuclear antibodies are caused by environmental toxins and Lyme disease. Wow. Same thing with rheumatoid factors. People come in and say, I think I have Hashimoto's thyroiditis. My antithyroid globulin and antithyroid peroxidase are positive. Lyme causes that through a process called molecular mimicry. So your immune system is trying to go after the bug, but instead of just going after the tail of the spirok, it goes after your thyroid. It goes after your pituitary. Because the proteins are similar, right? Correct. It goes after your myelin sheets. You get anti-milin antibodies. You get demilination, which looks like MS or looks like ALS. 10% of our ALS patients who came in did not have

Starting point is 00:49:50 true ALS. Wow. They had Lyme-induced ALS. We were able to stop the process and reverse. it. Wow. Right now, most unfortunately, our genetic with superoxide dismutase problems, but if you're the one out of 10 that's lucky, they didn't know that the demyelination was from infections, from toxins, from the wrong microbiome. So in other words, all these factors on the MSIDs model are interacting with all the rest causing demyelination. And then your immune system is suppressed by these toxins and infections with autoimmune reactions. Then we have the liver. One third of the world's population has fatty liver. Why is that a problem? And That's caused by PFAS, by the way.

Starting point is 00:50:27 Yeah, non-alcoholic fatty liver. Not alcoholic. It's called non-alcoholic fatty liver disease. So why is that a problem? It causes metabolic syndrome and insulin resistance. And you get cirrhosis later on in life with liver cancer and your doctor never knew because you had no symptoms. These are a silent liver disease

Starting point is 00:50:48 that is affecting one third of the world's population. Wow. And metabolic syndrome and insulin resistance is related to Alzheimer's disease. It's related to, It's related to cardiovascular disease. It's related to cancer. So every one of these MSIDS factors

Starting point is 00:51:01 is affecting every other disease that's there. And this is not known, and I didn't even know this until I started writing end in chronic illness. So we're dealing with the liver, the hormones, the mitochondrial, autoimmune immune pain syndromes. People would come in,

Starting point is 00:51:15 I had a woman come in on 480 milligrams of morphine sulfate for pain. This was a young woman, oh, you're gonna love this story. Wow. She's 15 years old, she comes from the south, She's actually from the Tennessee area. She comes in with her mom.

Starting point is 00:51:27 But no trauma, no, no post-surgical was just pain. Just comes in. Her mother flies her up in a wheelchair from the South. And she says to me, I've seen eight doctors, including seven neurologists, no one can figure out what's wrong with my daughter. She's tired, she's achy. She stands up and she starts passing out.

Starting point is 00:51:44 You'll probably know what that's about to be. Yeah. And she's got this incredible pain, this neuropathic pain in her body on morphine. The pain is not controlled with 480 milligrams of morphine. Oh my gosh. So I take it, I give her the HMQ, the Horowitz-Mpsons questionnaire, and she says, yes, I have migratory pain all over my body. Now I'm going to show you how I made a diagnosis without a blood test. I went, well, there's only seven diseases in medicine that cause migratory

Starting point is 00:52:09 pain. You don't have lupus, right, based on the way she was presenting with butterfly rasses. She did have got a cochle arthritis. She didn't have inflammatory bowel disease. She didn't have writer syndrome. So in other way, she didn't have these other diseases that caused migratory pain, right? She then, we stood her up with her mom, and she started, her heart weight went to 140. She had pots dishononemia, postural, autostatic tachycardia syndrome. What are the four major causes of pots? Lyme disease, Bartonella, long COVID,

Starting point is 00:52:39 which at the time when I saw her COVID wasn't even around, and mold. Those are the four major cause that usually cause postural autostatic tachycardia, although Ella Danlo syndrome and Marfan's and other things with, as you know, with hypermobility syndrome can be affected. Yeah, she has it. Yeah. She's not by him. Has pots.

Starting point is 00:52:55 So we knew already are, so it's the pots that's causing these pseudo seizures that she was having. So she picks up her shirt, I examine her, and she's got these

Starting point is 00:53:03 stretch marks across her body that are purplish, and she was never overweight. She had the classic Bartonella stretch marks that were present across her breast marks.

Starting point is 00:53:12 They looked like somebody gained and lost 200 pounds, and these are very classic for Bartonella. So right now, migratory pain, I knew she had Lyme.

Starting point is 00:53:21 Right? Potts, we knew because we stood her up and her heart went up, and her blood pressure drop. We knew she had Bartonella because she had the classic rash, like Lyme has the bullseye type rash, which half the time, by the way, doesn't look like. I haven't heard of the stretch marks.

Starting point is 00:53:33 So it is a classic. If you look it up, I can show you the journals. Yeah, no, I believe that. They're purplish or they're whitish. And a lot of times they're perpendicular to the skin plane, but a lot of times they're whitish and they look like a Christmas tree pattern where they're perpendicular and they can be purplish.

Starting point is 00:53:49 And they change, by the way, when we treat it. But she also said to me, yes, questions, one in 22 on the age computer, I have drenching sweats. Now, this girl's 15 years old. Now, when men would come in with drenching sweats, I used to say, I'll bet you're in manipause. They liked the joke, by the way. But so she had babesia.

Starting point is 00:54:06 So without ever doing a blood test, I said to the mother, I know why you saw eight doctors and your daughter's sick. She has Lyme, she has bobezia, she has bartonella and she has pots. So she left the office, we drew the blood. I put her on, and at the time, we weren't doing as much with dapsone.

Starting point is 00:54:22 I put her on doxycycycycy. I gave her salt, fluids, and licorice to raise her blood pressure. Salt fluids are in licorice. Just to raise her blood pressure, right? And we started treating the Babesia with some malarone. She flies in one month later. This girl was in a wheelchair unable to walk on morphine. She's off the morphine.

Starting point is 00:54:41 She's walking out of her wheelchair and she has no pain whatsoever. After one month of treatment of her Lyme Babesia Bartonella and treating her pots appropriately. And now you would use something more biofilm Now I would use Dapsone therapy with these biofilm agents. At the time, we didn't even know this. But the point being, that was the 90% we talked about is how do you make a diagnosis?

Starting point is 00:55:01 You pull it out of the history out of the patient. It was by taking a good clinical history and examining her. Wow. And I've had patients in wheelchairs who couldn't walk. We treated their parasite with Babesia. They get out of wheelchairs and they start walking because the parasite was affecting their immune system

Starting point is 00:55:16 and making them so weak they couldn't. Or a woman who couldn't talk for five years. Words would not come out of her mouth. It was called dysarthria and aphasia. Like if she had a stroke, she went to Mass Channel, nobody could figure it out. It was Bart Nella. We treated Bart and she started saying words.

Starting point is 00:55:31 So I have seen these kind of crazy cases where people have seen 10, 20, 30 doctors. The key that I'm noticing for all these chronic fatiguing musculoskeletal neurocyte is you gotta go back to the 16 point Msids model. It's where I'm finding the solutions and I've done this for 41 years. And does that panel catch all of these?

Starting point is 00:55:50 I mean, the panel that you just described earlier in the podcast, it catches all of these, because I've got to put a link to that in the podcast notes. Yes. And also, you know, in my prior books, but in the chronic illness, I discussed the panels in the first 30 or 40 pages, I discussed the panels for Lyman Bartonella. What are my favorite labs?

Starting point is 00:56:06 What are the labs you're going to do from mold? What are the labs we use for the adrenal dysfunction? All of this is in the book so you can take it to your doctor and you can work with your functional medicine doctor or train your doctor, right? And just teach them what these tests, but everything is laid out clearly

Starting point is 00:56:20 as a roadmap to get these paper back to health. Wow. And then once you have this data on the pathogenic invader, it can't be as simple as that short course of antibiotics and then a long course of probiotics, or is it? So the interesting part for Lyme is for the people, like my wife was sick for 25 years with Lyme disease. And before I knew the dose of dapzone

Starting point is 00:56:44 that was needed to cure Lyme, and I'll tell you, the universe is very kind to me. So I was in prayer years ago of please let me have solutions for these chronically ill patients. So what happens? A guy comes into my office, he's seven years sick.

Starting point is 00:56:57 I give him the Dapzone protocol, but at the time I was using 100 milligrams a day. He comes in month four and he says, Doc, I'm feeling terrible. I said, oh, what's going on? He said, oh my God, I'm so tired. I'm achy, I'm brain fog. I said, oh, what are you taking?

Starting point is 00:57:10 Well, I'm taking Doxy, I'm taking refampin and I'm taking Dapzone twice a day. I said, oh my God, you're taking too much Dapzone. You're taking double the dose. I said, stop. it, come back in a month. He comes back in a month. He was sick for seven years and he goes, Doc,

Starting point is 00:57:23 I feel amazing. I went, huh? He said, I'm off all my treatment. My energy is fabulous. My brain fog has gone. The joint, I said, what? I said, don't do anything. I don't want you taking any more medication.

Starting point is 00:57:35 Come back in three months. He goes back in three months, he says, I'm well. Is he still on it? No. No, he's off. Because he took double, he took 100 milligrams of Dapsone for one month, which I didn't know at the time

Starting point is 00:57:46 was enough to get Lyme in remission, we thought we didn't know the dosage. Right. So for Bartonella, it's a little different. But ultimately, what we found out is it's a nine-week oral protocol. So my wife who did 50 of Dapsone for a year said, Doc, a hubby, I feel great. She stopped it. She was PCR positive for Lyme in her blood.

Starting point is 00:58:05 Wow. We did a hundred of DAPSone. Huh? The hundred of Dapsone. We did a hundred of Dapsone for six months. She said, I feel great. She stopped it. She relapsed.

Starting point is 00:58:13 I said, you know, honey, this guy just came into my medical office. He took a double dose of Dapsone. Would you like being my guinea pig? She said, absolutely, Rick. She took 100 of Dapsone twice a day. She's eight years in remission. For how long? Eight years.

Starting point is 00:58:27 No, no, no. For how long did she take the... One month. 30 days. But now she had done a year of Dapsone at 50 milligrams. Right. Six months of Dapsone at 100. So she did a year and a half of lower dose

Starting point is 00:58:37 and she lowered the biofilm persistural load of the bacteria. So she only needed one month. But ultimately, I got this protocol after tweaking this and playing around with. thousands. Yeah. It's a nine-week oral protocol. So if you don't have Babesia and Bartonella or mold, and you take this protocol for chronic Lyme, you will most likely go into remission. I publish this, it's at least 50% of the people that go into long-term remission. Most of the people that don't,

Starting point is 00:59:03 they have active parasites like Babesia. They have other intracellular bacteria like Bart. If you have barred, you need four two-week pulses of oral, this oral generic protocol, and it's only six days of dapzone, right? Just six days. and that will put a lot of these Bartonella patients into full remission. Wow. So I have gotten this protocol down to very short-term oral antibiotics

Starting point is 00:59:24 while giving you four probiotics twice a day, 500 trillion of these bacteria. Four probiotics twice a day. So no C-Diff, no problems with yeast overgrowth, with nis statin. And you can take that with the antibiotic. Right, but I'm also giving you, I'm blocking and stimulating

Starting point is 00:59:40 four inflammatory pathways, so I'm blocking inflammation. And I want to go through this because this is really important. I want to go through this too. For those of us who want to optimize our health, I discovered that not only are these 16 MSSIDs factors underlying cancer, cardiovascular disease, chronic fatigue syndrome, autism,

Starting point is 00:59:57 every disease pretty much the major diseases, but there are 16 inflammatory biochemical pathways underlying these 16 factors. So you would recommend this even if somebody doesn't have a line, just to go through this and like I do parasitic detox. Correct. So I'm going to talk to you about the first four pathways that when people take dapsum. I'm doing this. And by the way, this is what I take every day.

Starting point is 01:00:20 So I don't know if this is embarrassing at this point to show you, but like that is my dinner time and this is my breakfast. Now, you and I might be able to talk. You don't even have eggs or steak or chicken or anything. It's all in there. You and I should talk after this podcast about how to maybe put this in a drink and get this so people don't have to swallow what I'm doing. But let me tell you why I'm doing what I'm doing.

Starting point is 01:00:44 Every family member in my immediate family has died of a different form of cancer. My mother died of lung cancer and she had cervical cancer. My father died of pancreatic cancer and he had an early case of colon cancer. My uncle Al, who delivered me at my Monadies Hospital in Brooklyn,

Starting point is 01:01:01 he had a form of prostate. Every aunt and uncle, they're all dead. Wow. They're Ashkenazi Jews. I don't know what their BACA status was. But I discovered when I was looking at cancer that all 16 of these, It's factors affected cancer,

Starting point is 01:01:16 but there were pathways driving cancer. So when I did the DAPSone protocol, and people said to me, I feel horrible when you're killing the bacteria. I knew I had a block inflammation, as we've talked about. Chronic inflammation is driving almost all these chronic diseases. That's the roadmap to health, right?

Starting point is 01:01:33 To both stay healthy and to reverse it. So what did I do? The first pathway on this protocol is blocking a pathway called NFCAPA B. NF Kappa B is the number one switch inside your nucleus, When it turns on, you get two necrosis factor alpha, interleukin 1, IL-6, you get all these inflammatory molecules. And necrosis factor is something that is prolonging or interrupting autophagy, right?

Starting point is 01:01:58 I mean, what? Correct. So you bring up a very important point. So our cells need autophagy. We need to clean house. Right. On time, yeah. In time.

Starting point is 01:02:07 So if you have damaged mitochondria, if those mitochondria do not go through autophagy, If you can't clean those out and get rid of them, that's gonna lead to Alzheimer's disease. That can lead to autism. That'll lead to cancer. Damaged mitochondria without autophagy is going to lead to this problem, right? So these inflammatory pathways

Starting point is 01:02:26 are showing up in autism and cancer, and chronic, in all of these diseases. So when I give people this Dapsone protocol, I'm not just giving them antibiotics. I'm giving them probiotics to support the gut, but I'm giving them NAC, NACC, N acetyl Sistine, a precursor of glutathione, right? Right?

Starting point is 01:02:42 Which is what? Which is what? Which is a precursor for glutathione. Enacetyl cystic. Enacetyl cystin helps the body, cystin, you need cystin glycine glutamic acid to make glutathione. Right.

Starting point is 01:02:53 So if you're eating a high protein diet with lots of cysteine, right? Way-based protein, you're getting a form to help your body to make glutathione. Why is glutathione so important? It's the number one master antioxidant in the body. Now when people died of COVID during the first wave, we talked about this earlier.

Starting point is 01:03:10 They were dying from ARDS, acute, respiratory distress syndrome. They had white outs in their lungs. Most people don't know that you have 140 times more glutathione in your lung tissue than anywhere in the world. They did not know that. So if you have toxins from the environment

Starting point is 01:03:24 and you used up all your glutathione. And now you got the virus using up glutathione. And you didn't have enough glutathione, you were gonna get acute, right? So in the protocols I use, we block this first switch that drives inflammation using NAC, alpha-lypoic acid, really interesting.

Starting point is 01:03:41 It regenerates glutathione intracellulally. It's water soluble, fat soluble, gets up into the brain. It regenerates mitochondrial function. And it's one of the most powerful antioxidants that exists while regenerating mitochondria and regenerating glutathione, and then we give them glutathione. So the first thing that I do, and this is the supplements I take. NAC, alpha liposac acid, glutathione.

Starting point is 01:04:04 I'm blocking that number one switch, right? NF Kappa B, which shows up in autism, Alzheimer's, cancer, chronic fatigue, every major chronic disease, pretty much you're gonna see. Wow. The second pathway I stimulate called the NRF2 pathway. So NRF2 really important pathway. Yeah.

Starting point is 01:04:20 This is how you stop your genetic, so every one of my family died of cancer. This pathway tells your genetic structure to hit the P53 cancer gene and shut it down and open up your detoxification pathways to help shoveling out these environmental toxins. All of these psychotective proteins. Correct.

Starting point is 01:04:37 Exactly, that's it. So how do you stimulate NRF2? turmeric curcumin, broccoli seed extract, sulfuricine glucosinate. If I, oh my God, that is like one of my favorite supplements of all time. Because that is so important in hitting this P53 gene, do you know that they gave sulfurphane

Starting point is 01:04:56 to autistic kids between 100 to 300 milligrams and they started reversing autistic syndrome? Because it hits a biochemical pathway called the mTOR pathway, right? The mechanistic target of rapamycin, which you need for longevity. Right. Well, the mTOR pathway,

Starting point is 01:05:11 people think autism and Alzheimer's, they're two different diseases, they're not. They're on a different spectrum of neuro-inflammation in the brain. And if the mTOR pathway is hyper-stimulated in autism and Alzheimer, how do you lower it? Broccoli seed extract. When they give Alzheimer's patients,

Starting point is 01:05:28 we're gonna talk about your mom later. Okay, good. When they gave sulforaphate glucosinilate to people with dementia, they noticed their cognition improved because it stopped this overactivation of this pathway. So broccoli seed extract with curmin, with green tea, EGCG, right?

Starting point is 01:05:43 Very, very important. So Cochermin, green tea, broccoli seed, and very, very important with broccoli seed extract. These will stimulate a pathway called NRF2. The third pathway is called NLRP3 in phlamasomes. Now this is important in cancer, in Alzheimer's disease, in most chronic illnesses that you're going to see.

Starting point is 01:06:03 How do you shut it down? Well, it turns out these first two things we talked about, NFCAPB, NRF2, if you take these supplements with curmin, broccoli seed extract. Resveratrol, by the way, is also a great NRF2 stimulator. It hits the certhuan genes of the body for longevity, right? It's part of my protocol. It also affects NLRP3 in flammasomes,

Starting point is 01:06:22 but you also do it with low-dose naltrexone and low-dose melatonin. Wow. So in al-D., so if you have a problem sleeping with LDN, I take actually mine in the morning just to make sure it's not, but I take 4.5 milligrams of low-dose-naltrexone compounded through infuserv in Florida.

Starting point is 01:06:39 It's my favorite compounder. And I take it with very low dose, one milligram melatonin, to block NLRP3 inflammatory lymphombs. And the fourth is inflammatory prostate glandums. Take, if you're eating healthy fish, which difficult these days, you can, you know, wild organic salmon. Fish has great omega-3s, but I take a mercury-free fish oil.

Starting point is 01:06:57 I take ortho-a-o-o-megra-molecular. But these first four pathways are among 16 inflammatory, but when you look at all 16 pathways, if you were to take things that block NF-CAPA B, an acetyliscylasease, alpha, hypoic acid. Now, I should tell you, you have to be careful with alpha hypoic acid. If you're hypoglycemic like I am,

Starting point is 01:07:16 if you take 1,200 milligrams, which is pretty much, you have to be careful with blood sugar swings. Yeah. Now, not one of my patients died during COVID when I gave them this protocol. Why? We now know that there were microclots

Starting point is 01:07:29 that were forming with COVID, and now some people think these spike proteins are in the body causing inflammation in these nutrifil extra cellular traps. It's driving inflammation. Why did none of my patients have a problem because I told them,

Starting point is 01:07:41 and it's still on my website from 2020, because I published the first article on glutathione for COVID, I told him to block NFCAPA B. I didn't realize at the time that COVID virus needs to lower glutathione to replicate. I didn't know that either. When my patients now get COVID.

Starting point is 01:07:57 It needs to lower glutathione to replicate. So influenza virus has to lower glutathione to replicate. Wow. So does den fever, so does HIV. So does COVID. So by taking, when I get COVID, I've had it twice, I take 2,000 milligrams of glutathione three times a day with any six times a day, three times a day.

Starting point is 01:08:14 Three times a that's the maximum dose that you normally can take. Okay, 6,000. And not one of my patients who did this generally ever fell ill. Not one person died. I only had two people in the hospital and they were both immune deficient by the way for COVID. But when you stimulate NRF2 with curmin,

Starting point is 01:08:30 resveratrol, broccoli seed, green tea extract, you take NACC, alpha lipos, glutathione. You take LDN, Militonin and a multi-mineral supplement, very important. Yeah. I take Minorex from Zymogen, which has copper and zinc and magnesium. I take magnesium malate as well as magnesium glycinate. Sometimes you'll threanate if I have a problem sleeping at night.

Starting point is 01:08:52 But you need a multi-mineral, as we talked about, for these detox pathways. And I told people to do this with omega-3 fatty acids. All of my patients did well during COVID simply by looking at the virus driving inflammation and saying, how do we block inflammation? How do we lower inflammation? It was very logical, so Paxlovid is very good to stop the virus from replicating. People get less long COVID when they take it.

Starting point is 01:09:15 But it's still, as you know, people get relapses and they get rebounds. And a lot of people get Epstein-Borin-HV-6. And this could be from the glutathione deficiency. Correct. So again, you've got to look at your immune system. It's not just getting COVID. Do you have these other infections and toxins

Starting point is 01:09:29 and microbiome issues? All of this is now shown up with long COVID. Wow. So for these like 45 million Americans with long COVID who say, I don't know what, what to do. The last chapter in ending chronic illness, V is for viruses, it shows you how every one of these 16 MCIDS factors

Starting point is 01:09:44 is associated. Look at your adrenals, look at the microbiome of your gut, right? And you'll find if you address, by the way, a lot of these people that had a marker of long COVID called VEGF, vascular, it wasn't from the virus affecting the endothelium driving inflammation, it was Bartonella. Was it the VEGF driving up to cause this angiogenesis?

Starting point is 01:10:05 That can also be a good thing. Right, I mean, upregulating VEGF for tissue and wound repair. Correct. Like anything in the body, it's all about balance, right? But in the patients, when I did a long hauler panel through Patterson's lab in California, and I looked and I found that their cytokines and chemokines were up and they had VGF. Through the roof. Through the roof.

Starting point is 01:10:25 Okay. It wasn't just from spike proteins that were sitting inside the endothelial driving, right, the inflammation. Because they didn't know they had Bartonella. Bartonella causes elevations in VEGF. And I suspect at this point that a lot of the long COVID patients out there because I've seen many of them that have gotten better,

Starting point is 01:10:42 they didn't know they had Lyme, they didn't know they had Bartonella, they're viruses that reactivated and I have in the book some solutions for EBV that I think need to be looked at. Epstein Barr is a horrible virus that causes cancer,

Starting point is 01:10:55 burkitts lymphoma, right? Not just chronic fatigue center. And everybody's got it. It's really widespread. And so it undulates too. So if you look at the antivirals for Epstein Bar. Yeah.

Starting point is 01:11:05 It's like all these viruses these drugs like Artenis, they're not easy to tolerate. It turned out when I was doing the deep dive in the medical literature, that spironylactone, a drug they used for women with PCOS to lower testosterone, and dipyrodamol, persantene, a drug that's used to stop strokes

Starting point is 01:11:21 with transidishemic attacks, if you combine these drugs, which are very well tolerated with an antiviral like famyclyver, it shuts down the virus at every stage in the replication. Now, don't get me wrong. I need a randomized multi-center trial,

Starting point is 01:11:34 Secretary Kennedy, if you're listening to this, let's get the monies in this. But the point I'm making is, I did this dive in the literature and it's like I discovered all these things that it's like, oh my God, so many people are going to benefit, but yes, we do need the money

Starting point is 01:11:49 put into these studies because association does not always equal causation. But I do believe I found an answer for a lot of these illnesses that people are suffering. This gives them hope. We all spend one third of our lives sleeping. One third.

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Starting point is 01:12:37 because it meets my standards for human optimization. Sleep chemical free. Visit theultimate snooze.com and use code ultimate for 10% off. Now let's get to sleep. Now let's get back to the Ultimate Human Podcast. Wow. Wow. So I am definitely going to put this protocol in the show notes

Starting point is 01:12:55 and even the lab values in the show notes. I want to switch gears to not necessarily my mother per se, but cognitive decline. Alzheimer's, dementia, because as you said, if 42% of the population over 55 years old, which I'm about to turn that population, is expected to get one of these cognitive ailments, that to me is mind-numbing. It is. And it can't be that all of a sudden, half of the world's population at that young age is going to

Starting point is 01:13:30 suffer from. That's correct. And ultimately, what is it? down to inflammation in the brain, right? So all of these diseases we're talking about, whether it's neuroinflammation, these microplastics that get into your arteries. Yeah, insulin resistance in the brain.

Starting point is 01:13:44 It's the genocry strokes, heart attacks when they get in here. So what's interesting about inflammation, inflammation in the brain, Alzheimer's. Inflammation in the heart, heart attacks, congestive heart failure. Inflammation in the joints, rheumatoid arthritis. Inflammation in the skin, scleroderma, psoriasis.

Starting point is 01:14:02 You name the organ, and I'll show you where inflammation is causing disease we're talking about. So then the problem is, well, where's the inflammation coming from? So unfortunately, they spent $2.4 billion a year of NIH funds, and I had to be the first guy who told them that there's not just an association of Lyman Alzheimer's, but causation, and by the way, it's not the only cause.

Starting point is 01:14:24 We'll talk about this to a second. All 16 MSSIDs factors that we're talking about today, the six rivers of inflammation of infections, toxins, microbiome, leaky gut, with mass cell activation, vitamin mineral, sleep disorders, 10 downstream effects, mitochondrial,

Starting point is 01:14:40 hormonal dysfunction, liver disease, pain syndrives, immune, autoimmune, all of these factors are been showing up in Alzheimer's. So in this article, I just published, if someone went to the neurologist

Starting point is 01:14:51 and said, I have cognitive decline and they did a Moka test, right, Montreal Cognive Assessment, and they didn't score well on it. This is exactly what happened to my mom. And they did Alzheimer's biomarkers. So what are these biomarkers you need to check?

Starting point is 01:15:05 And these are not being routinely done, by the way, by physicians. So you first want to check. And this is, by the way, my favorite is Quest Labs, covered by insurance. The amyloid beta 4242 ratio is the first biomarker you want to check. Okay. If you have a low ratio, that is bad. You don't want low. Normally we think, you know, a low ratio means you're taking the sticky protein amyloid beta

Starting point is 01:15:26 42 and you're depositing it in your brain. That's not what you want happening. So first biomarker amyloid beta 424. Second, p-tow phosphorylated tau-181. Third biomarker, p-tow phosphorlated tau-217. Now, that is the most specific sensitive and specific biomarker for Alzheimer's, and that's the biomarker that it reversed

Starting point is 01:15:48 with the nine-weekedapsone protocol in my patient. Now, what's great about this study that I just published is this patient was sick with chronic Lyme for 15 years and had not touched one antibiotic in 15 years. All I did was give her the nine-week oral dapsone protocol and three months later her Alzheimer's biomarker completely reversed to normal and I didn't realize it at the time

Starting point is 01:16:10 when I published this in the Journal of Alzheimer's Disease Reports. No one had ever done this before in the world medical literature. Wow. The anti-ameloid drugs lower these biomarkers by 23% in six years. Oh my God. I lowered it by 63% in nine weeks. because the amyloid was being driven

Starting point is 01:16:27 by Lyme Borrelia burgdorferi. Okay. So you need Ptow 181, Ptow 217, and the last one is neurofilament light. Now, this is a non-specific marker of inflammation, not specific for Alzheimer's, but what's nice about that is if you have hypertension or cardiovascular wrists or even other diseases,

Starting point is 01:16:46 and you have inflammation from IL6, no matter what the cause. Like an endothelial marker? Yeah. That neural filament light will show up as a marker saying you better do a better job in the inflammation in your body. The fifth biomarker is if you are APOE-44,

Starting point is 01:17:00 which is the genetic marker for Alzheimer's, which by the way, none of the patients I checked in my practice were APOE-44. Wow. They still reversing biomarker. So, well, because of the pathogen, yeah. Yeah. So, but the last one is called

Starting point is 01:17:13 glial fibroac acidic protein, GFAP. Okay. So if you are Alzheimer's APOE-44, you want to get GFAPE, leal fibricic acid because if that's positive, your 10 year risk down the line is gonna be high, you're gonna develop dementia. You don't have to do that biomarker

Starting point is 01:17:30 if you're not APOE44. Okay. Now I discovered in my patients before I finished clinical practice after 41 years of seeing 13,000 these patients, that half of my patients were showing up with these Alzheimer's biomarkers. Wow. And I asked a colleague of mine.

Starting point is 01:17:44 The predisposition genetic markers? No, no, no. The actual blood mark. Okay. Oh yeah. Okay. were showing up with low beta amyloid 4240 without even having a predisposition, which means one of these pathogenic invaders. Correct. Wow. And they were never, and you're not taught in

Starting point is 01:18:00 internal medicine. Do a prostate exam. Go for a colonoscopy. Check your cholesterol. Check your blood pressure. Check your hemoglobin. All good. But now that you know the risk of dementia is 42%. Wouldn't you want to check your Alzheimer's biomarkers? Of course you do. Because it's silent. You want to know if you have neuroinflammation in your brain before it happens, right? So these are covered by Quest Laboratories by LabCorp, but I like Quest specifically the way they do it. So you would want your mom specifically, if she's having issues,

Starting point is 01:18:29 to look at these biomarkers. Now, you also want to look, however, at the 16 MSSIDs factors we talked about. Now, I don't know your mother's clinical history at all, but I would want it to fill out the HMQ on my website, can get better, and see what her score is. We're filling it out right after this podcast. We'll speak about it.

Starting point is 01:18:46 I want to know, does she have any migratory pain? I want to know if she has any neuropathy with tingling numb. I want to know what her symptoms are, right? So I want to look at the infections, but not just Lyme. I want to look at Bart. I want to commit a pneumonia. So I, and this is all in my book. This is under A is for autism, ADHD, Alzheimer's, allergies, asthma.

Starting point is 01:19:05 So in one of the chapters in any chronic illness, you will find all 16 MSSID factors. All you got to do is take it to your doctor, go to the lab and go, these are the bugs I want to check. This is the way I'm going to check mold. You just go through the list. It's a checklist. It's simple.

Starting point is 01:19:21 So that is what we need to do. And you and I are going to be in correspondence because I want to show you that this is possible and prove this to you because I've already seen results in my patients. By the way, the number one effect of Dapsone, the number one of all these patients

Starting point is 01:19:33 is cognitive improvement. Wow. So when I published my 10- Any age. Any age. I've had 80-year-old people come in. Doc, I'm tired. I'm achy. My brain's not working.

Starting point is 01:19:44 I'm sure I have out. Alzheimer's like, you know, Alzheimer's, you have Lyme. I treat them with Dapsone, and they come back months later and go, oh my God, it wasn't, I was getting old, because I hear this all the time. I'm getting old. It's like, getting old doesn't mean anything. I'm 70 years old. I feel like I'm 25.

Starting point is 01:19:58 That has nothing to do with it. So, but you treat the infections that were underlying, the fatigue, the pain, the cognitive difficulties, right? The neuropathy, the sleep disorder, the mood. Do you know that one out of five people in the U.S. is depressed and anxious? We have mental health. Yes. We have a mental health epidemic.

Starting point is 01:20:14 all 16 factors on the MSSID's model are causing mood disorders from depression, anxiety, OCD, bipolar disorder, and schizophrenia. I've had people with schizophrenia with hallucinations reverse the hallucinations by treating the lime and the bartonella and getting rid of mold,

Starting point is 01:20:32 not giving them zyprexa for the rest of their life for their psychotic break. Medicine needs to know. You can't just name the disease and throw drugs at it. You've got to unlayered to the 16 root causes. and that is what is in chronic illness. This is why I think ending chronic illness,

Starting point is 01:20:48 I hope will be, it will be really kind of the manual for people, both for patients who say, hey, I'm well, but I don't want to get sick. For the patients who say, I've gone to 30 doctors, I can't figure out why I'm ill, right? For the providers that say,

Starting point is 01:21:02 oh my God, I'm seeing all these chronicleal patients, I don't know what to do, right? And for those parents that say, and I just got this call from this patient, this, I get calls from all over the world. I got one just yesterday from a UK, from a mom. My five-year-old is so sick with Lyme. I can't find a doctor to treat.

Starting point is 01:21:20 How do I get them better? It's heartbreaking, listening to these stories. Everything I have published is in the open access medical literature. You just go to the open access literature. All of my protocols are in the literature. You don't need to speak to me. It's all published for you. Everything I did is oral generic.

Starting point is 01:21:39 So it's the cheapest, fastest way to get you better because we're in a worldwide epidemic. So Alzheimer's, yes, you need to go through those 16 points and you need to go through these Alzheimer's biomarkers. That's gonna be for me the first step to see kind of what is going on. Do you know if your mom has actually been checked for these things?

Starting point is 01:21:56 No, she hasn't. I know that she hasn't. For mold or for mold? Yeah, I've done a vibrant wellness mold metals. Mycotoxins, Aflatoxin A was there, Aflatoxin B. So she had these. Okra toxin.

Starting point is 01:22:10 Oh yeah. She had, as most my patients have too. Yeah. Yeah. Yeah. And the beauty is, I found that there's a protocol and I describe it. But I want to do the rest of this testing. Yeah.

Starting point is 01:22:19 Yeah. Yeah. In any case, yeah, so in that case, this testing is going to be very important. But also, what I describe in any chronic illness, we now know that inflammation, chronic inflammation is underlying chronic disease. So I have a part in the book where I'm going to give you stage one, stage two, stage three testing. Stage one testing is general inflammatory markers. CRP, C-reactive protein,

Starting point is 01:22:41 indirect marker of interleukin 6, erythrotite sedimentation rate, TGF beta 1, which we see in lime, we see in mold. C4A, we see in lime, we see in mold, right? So MMP9, which you can see in joint inflammation, we see in line. So I'm gonna give you the 10 general markers of inflammation, but then the second stage is, well,

Starting point is 01:23:01 not all these biomarkers necessarily show up. So you can do, and I'm sure you know this, you can go to functional medicine laboratories and check lipid peroxides to see how much free radical stress is affecting the outer membranes. You can do eight hydroxyguine to see how much your DNA is affected

Starting point is 01:23:16 or protein carbonyls to see how much oxidative stress affects your proteins. So you go to a precision point diagnostics or doctor's data, some good functional medicine lab, and you get, so all of these biomarkers done, this is the second level of testing with, let's see, a T-Bars test. To see how much free radical oxidative stress

Starting point is 01:23:33 because CRP may be normal, said rate may be normal, a VGF may even be normal with Bart. Sometimes it shows up high, with long COVID sometimes, it does it. It changes over time. But the third level of testing is what we're talking about for your mom.

Starting point is 01:23:47 You wanna go ahead and get these Alzheimer's biomarkers biomarkers done and maybe even get chemokines done from somebody like Patterson's lab to see whether you've got CXL3, CXL4, CXC, look at these chemokines that are now looking at these very specific biochemical pathways. So you can go backwards and go, hold on, the interferon gamma's high, is that maybe a virus?

Starting point is 01:24:09 Or is it, so you can kind of go backwards when you get back the results of all this testing. And so I divide it up into these three levels of inflammatory testing, which makes sense in seeing how you do these biomarkers. Wow. And these are multiple labs. So so far you've named five labs.

Starting point is 01:24:26 Right, but although the good news is a lot of them can be done through Quest, LabCorp BioRef. They can be done through local lab. I wanna definitely get the baseline done as many as we can through Quest. Yeah. I mean, I like, you know,

Starting point is 01:24:38 Doctors Data, Airon, like when I'm doing, doing a DHA cortisol saliva, I like functional medicine labs. Yeah. If I'm doing a six-hour year at MSA challenge for metals, I like doctors date in Chicago. Yeah.

Starting point is 01:24:49 But that's a $60 test, right? I mean, these are not expensive tests. Right. I think the saliva test is 100. These are not expensive tests for people to do. And yet they're so important because here you're trying to optimize your health, you're doing mitochondrial, you're exercising.

Starting point is 01:25:03 If your adrenals are low, you may never figure out why I just never feel like I've got that that bump to get through the day. because you missed that one nail in the foot of the 16 points that you just left it off. That's the beauty of a checklist. You don't have to be a rocket scientist. Just look at the checklist

Starting point is 01:25:19 and start looking and just seeing, what have you checked? What haven't you checked? It's a very logical way of just approaching all of these different chronic illnesses. And even for people that are like in my condition that just want to be the best version of themselves, they should still just prophylactically do this protocol.

Starting point is 01:25:35 So that you can, because we all have something. Of course. Right, I mean, the, you know, just a daily environmental exposure. We all have something without even fear mongering. And this is a way of at least cleaning that slate so that it doesn't accumulate and become. Correct. I mean, look, I'm in good health. I'm 70 years old.

Starting point is 01:25:58 I feel great. But my whole family died of cancer. There's not one person left. Wow. So here's the thing. I want to block NFCAB because I found out that NFCAPAB even in cancer. It's not just affecting Alzheimer's and autism and ADHD. That same switch is affecting cancer as well as mood disorders, right?

Starting point is 01:26:16 So it's kind of like when you block that switch or you stimulate NRF2 with resveratrol and curmin and broccoli seed extract and green tea, you're opening up your detox pathways. You're hitting the P53 cancer gene. You know, you're lowering down inflammation in the body. So if you're doing hyperbarics and you're doing saunas and you're doing, right, all of the great things you're doing, I mean, you took me around. I mean, God bless you. It's fabulous what you're doing.

Starting point is 01:26:39 Thank you. But if you've still got free radical oxidative stress coming from infections and toxins of the microbiome, you're- swimming uphill, yeah. Right, exactly. It's like trying to detox someone from a mold infection while they're still in a moldy home, you can't do it.

Starting point is 01:26:52 I mean, that's the cardinal rule of detoxification. You know, is remove the toxic loads. So I think living on the planet, I mean, the reason I'm swallowing these supplements is once I learned that these biochemical pathways, that there are these 16 M-SIDS factors, with 16 biochemical pathways underlying. Even these first four pathways in ending chronic illness,

Starting point is 01:27:13 just with these 10 or 11, 12 supplements, you're already covering most of these 16 biochemical pathways. And it shows up in almost every chronic disease I looked at from depression to anxiety. So, you know, we've got a suicide, 750,000 people, right, who suicide, you know, worldwide. We lose more of our military servicemen to suicide than we do to battle.

Starting point is 01:27:34 Yeah. You know, when you start looking at those kind of statistics, The same with law enforcement. I mean, these rates are so high. And by the way, in my population, a lot of these people had PTSD. And the mind-body connection was so strong in these people that if they had abuse,

Starting point is 01:27:51 if they had physical abuse, emotional abuse, or sexual abuse. And I always ask about this because I had some abuse issues when I was young and I understand what they were going through. If we treat them, if we treat the infections, if we remove the toxins,

Starting point is 01:28:05 and work the microbiome, and do the mitochondrial, and we don't affect, and we don't work on the brain, we don't work on the mind and the emotions by doing vagal retraining and limbic retraining, right? I have to get through people, not just through EMDR, eye movement reprocessing, or doing cognitive behavioral therapy.

Starting point is 01:28:22 I've got to do limbic retraining with the antihopterdhydridebral retaining or the gutta amygdala insular retraining or primal trust. I have to use ways of getting into your brain with the amygdala and hypothalamus and going, you're wired for illness. because you had severe stress and trauma as a youngster.

Starting point is 01:28:41 A lot of these people took on like, there must be something wrong with me. And when you feel that, when you've been traumatized, your immune system won't work well. You can't fight the infections. You can detoxify. So I found in some women that when I address the PTSD

Starting point is 01:28:55 through vagal and limbic retraining, all these other things I was doing to make them better finally work. But if I didn't address it, and that's also, think about it. People optimized their health with high intensity, interval training and mitochondrial,

Starting point is 01:29:08 getting to sleep and proper diet. But stress, stress kills. You might be in a high stress job and all the things you're doing, your adrenals are taking a hit, your immune system taking a hit. The only time I get sick and your immune system is taking a massive hit.

Starting point is 01:29:22 Is when I'm stressed out, I don't get a good night's sleep, the virus will show up. If otherwise, I never get sick from things, but I meditate on a regular basis, right? I do stress, so people, if they wanna optimize their health, and by the way, I even have the meditation techniques

Starting point is 01:29:36 taught to me from my Tibetan teachers, I have them in ending chronic illness. Oh, wow. They taught me very, and I have a medical. How long do they take? Five minutes three times a day. Five minutes three times a day. Anybody can do this.

Starting point is 01:29:46 Anybody can do this. Even walking meditation outside on the street, you can look at the empty clear nature of your mind and pay attention to the inner environment and the outer once you learn how to do this. I was trained by, I've been very fortunate. I've been trained some really some incredible Tibetan masters. It's 45 years I've been training with them

Starting point is 01:30:05 and working with them. So I have a medical detective substack, by the way, that is free. I have a five-part meditation series, and I took their 45 years of teaching on the nature of mind of how to awaken, and I put it into a five-part substack on meditation. And again, this is all free for people to get,

Starting point is 01:30:22 because I wanted to make sure this information is out there, but even stress reduction, optimizing, how many people actually really unload during the day? And it's one of the most essential things for optimizing to stay healthy because you don't want to get short telomere, you know what short telomeres does longevity. You know what meditation does?

Starting point is 01:30:40 It lengthens your telomeres. It affects your autonomic nervous system and brings down your cortisol and brings down your autonomic and all that epinephrine in your body. You need to take a little break from a high-stress job and environment. So true.

Starting point is 01:30:53 Just five minutes, three times per day. And I made sure all of these kind of techniques are in the book so people could really benefit. Wow. Dr. Horowitz, this has been just an incredible... I have to have you back. I mean, there's so much to unpack here. I am gonna allow my audience to follow this journey. I've documented it so far with my mom

Starting point is 01:31:11 and I'll throw myself in there and document my journey. And this has been a really profound discussion. For my audience that wants to know how to find you, obviously I'm gonna put a link to the book, but how can they find you a social media or website? So I'm at all the social media channels. You can find me at can get better.com. Can get better.

Starting point is 01:31:29 And then chronic illness.com. Okay. Facebook, Dr. Richard Horowitz. So if you look up Dr. DR. Dr. Richard Horowitz, I have a Facebook account. Ali's helping me with Instagram. So yes, it's on all the social media. Okay, great.

Starting point is 01:31:44 So two other things. One, we're going to go into my VIP group because I told my VIPs that you were coming and they've got some great questions for you. If you're interested in becoming a VIP, you can just go to the Ultimate Human.com forward slash VIP and just sign up to be a VIP guest in mind. You get private podcast, private time with me,

Starting point is 01:32:01 hours and hours of live Q&As. You can ask me anything. This is going to be. be an amazing journey, Dr. Horwitz. I'm really excited to go on it personally and to take my mother on this journey. I wind down all my podcasts by asking all of my guests the same question.

Starting point is 01:32:16 What does it mean to you to be an ultimate human? What does it mean? What does it mean to you to be an ultimate human? So for me, an ultimate human is to maximize the potential. It's to maximize the physical, emotional, mental, and even spiritual, potential of every human being. Wow.

Starting point is 01:32:34 So this book and the chronic illness, it addresses the physical. It addresses, obviously, all the toxins and infections we talked about, but also the emotional about talking about I had trauma as young. I've done my healing journey. You did.

Starting point is 01:32:49 But I believe to be the ultimate human, it's physical, it's emotional, and it's spiritual. And because I have had the blessing of studying with these enlightened masters, which I met them in Belgium in my medical school. So very left-brain, right brain of you.

Starting point is 01:33:02 Yeah. That's exactly it. And so what I got from them is, they basically said that all things are possible. All things. But to get to that state where all things are possible, you have to go from your dualistic perception of me, you, good, bad, happy, sad, man, woman,

Starting point is 01:33:19 what I can do and what I can't do because our ego is wired in this life to limit our potential. And I believe because of some people have had the blessings of wonderful parenting and some have had challenges, but because we've all had challenges, in our lifetime.

Starting point is 01:33:35 For me, the ultimate human beings at this point, you wanna do your best to find out what your gift is to the world. What is your, what is your unique gift? You've obviously discovered yours, which is sharing your biological insights, right of systems biology and how you can get the word out to people. I hope I've discovered my, this is my new gift. I thought it was a gift for Lyme.

Starting point is 01:33:53 Then it turned out it was a gift for Alzheimer's and chronic fatigue and all these diseases. But how did I even get to this? It's because my Tibetan teachers taught me always work for the benefit of others. always work with compassion. People are suffering. Try and relieve their suffering.

Starting point is 01:34:08 Have love. When you say, I want to love you, it's like, I want you to be happy. Suffering, compassion. If you combine love and compassion in your daily journey and doing all the things that optimize your health

Starting point is 01:34:21 and doing high intensity interval training and mitochondrial, but for me it's on all levels. It's got to be physical, emotional, mental, and especially the spiritual level because if you're missing for me that dimension, then some of achieving your full potential of what is really possible.

Starting point is 01:34:37 I believe, by the way, that the only reason I have written this book or done anything I've discovered in medicine is because my teachers taught me that when you get to the state of the open, relaxed mind, where you meditate and you go to the bottom of the ocean where your true nature exists

Starting point is 01:34:52 and you can achieve this and touch this level, all things are possible at this level. And I believe that there is a way of working with that spiritual component that when you have the proper motivation of wanting to benefit people and do the best for them in their lives, I believe with that particular motivation

Starting point is 01:35:09 and then integrating the physical, emotional, mental component, I think we can become the ultimate human. But for me, it's also that spiritual component and that's why I've integrated into the book and I've done the medical detective substacks because I think they've given me such insights into the nature of mind

Starting point is 01:35:26 into what is possible. I think most people don't realize that they can go beyond the limit, of what they normally think, because the ego gives you limits of, I can do this, I can do that, but once you transcend the ego and you go from dualistic perception

Starting point is 01:35:40 to this unlimited open state of mind where all things are possible in what they call the state of Dharmakaya, it's very interesting because I didn't know in medicine, I could maybe, maybe find a cure and an answer for certain cases of Alzheimer's, for certain cases. I only wanted to go in medicine to benefit,

Starting point is 01:35:58 but the way they taught me to plant the seeds was plant the seeds of aspiration prayers. May I be of greatest benefit to the greatest number of people to relieve their suffering. I did that every day, 45 years ago when I started doing medicine. I must believe that I'm a spiritual human experiment

Starting point is 01:36:15 that these seeds I planted end up being with you today and writing this. Because I can't imagine how else, how I meant publishing all these studies and finding all these things. It was through that motivation of trying to benefit others. I was just led to the right place,

Starting point is 01:36:31 was ultimately working through that spiritual connection of how can I benefit others? How can I be of service? And that, for me, I think that is really, I think needs to be integrated. And especially from the stress component, just living the lives we're living, you need little meditation breaks during the day. Oh yeah, definitely. Dr. Horowitz, you are the ultimate human. Thank you for coming on the podcast. Thank you. Until next time, guys, that's just science.

The Ultimate Human with Gary Brecka - 302. The Antibiotics That Reversed Alzheimer's Blood Marker - Dr. Richard Horowitz

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