The Wellness Scoop - Ozempic & Weight Loss Drugs: Game Changers or Health Hazards?

Episode Date: October 16, 2025

This week we’re diving into one of the biggest health conversations of the year as we explore GLP 1 weight loss drugs. From Ozempic to Wegovy these medications have changed how we think about food, weight and willpower but they’ve also raised big questions about what healthy really means. Dr Jack Mosley joins us to unpack the science behind these drugs, the truth about food noise, muscle loss and long term side effects, and what happens when you stop taking them. We also look at natural ways to support GLP 1 function through diet and lifestyle. As these drugs become more accessible and more widely marketed are they a genuine breakthrough or another quick fix in disguise Learn more about your ad choices. Visit podcastchoices.com/adchoices

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And as always, we're here as your hosts. I'm Ella Mills. And I'm Rihanna Lambert. And today we are diving into some juicy topics as chosen by you. Now, we have had so many questions, haven't we, Ella, about weight loss drugs, GLP ones recently. And I think these drugs have obviously become, well, they've dominated a lot of the conversation and the headlines on health and wellness over the last year or so. We have just been inundated with questions from our community on the topic. So we thought now was the time to get our first expert guest in for our weekly Q&A so we can give you all the best answers to your questions. That is exactly right. So this is really exciting. So we're going to welcome Dr. Jack Molesley here today, who recently wrote a brilliant book called

Food Noise. And it was just this rigorously researched, deeply insightful guide to the rise of GLP ones, these weight loss medications. So Jack felt like the perfect person to come on and take your questions. But Jack, before we get into everybody's questions, I thought, you know what? Could we start at the top with just what are GLP ones? Yeah, thank you so much for having me and great to be here. So GLP ones are gut hormones and the reason they have become so interesting and so popular is because of their ability in reducing weight. I'll just go into how GLP-1s actually work and the kind of medical version of them,

the synthetic version. So, GL-P-1s, firstly, they've been used for 20 years in type 2 diabetes, and they work by reducing blood sugar. But the other kind of main ways they work is they slow down the bowels and they slow down your digestive tract. And this is one of the reasons why you actually have quite a lot of side effects with GLP ones as well, which I'll kind of get to later. But the reason they have really become so popular and so widely used

is because of their ability to act more centrally on the brain and they reduce your physical hunger, but they also seem to reduce your cravings. What's kind of become known is your food noise. And ultimately, that's how you lose weights with a diet. GLP ones. They reduce your cravings. They reduce your appetite. You eat less and you ultimately lose weight. Jack, thank you for giving that overview. I think what people perhaps are seeing GLP ones as is like this kind of magic drug, you know, a magic jab that will instantly

enable you to lose weight. Is there any way out there that this wouldn't work for somebody? Or is it pretty much 90 to 100 percent you will lose weight if you take this jab? For the most part, they do seem to work on most people, I'd say at least in the studies. And we're kind of seeing with semi-glutide, so that's a Zempic, you lose around 15% of your body weight in the trials over about a year period. And with Manjaro to Zepatite, typically people do lose around 20% of their body weight. But I think the really important thing to note is actually in these trials, people were provided a lot of support, a lot of nutritional guidance, and they were encouraged to exercise and do all these other things alongside it. So in the real world, we're

definitely seeing less weight loss and we're actually seeing slightly higher rates of people stopping these medications. It's so interesting. I know quite a few people we've taken them and one of them did it with quite a lot of that support and a nutritionist and a complete overhaul of diet and it was so effective and has seemed to kind of create amazing habits. But anyway, it's been very interesting to watch. But moving on to our community questions, this is from Anonymous, but I think it's such a great place to start. Jack, do you think this is going to become the norm? I think they're going to become more and more widespread in their use. And especially as we see more medications becoming available. So we are seeing there's dozens of medications in the pipeline

at the moment. So currently there are once weekly injections, but we will see injections at once monthly as well. And next year, we're likely to see these new oral medications come through, which are currently in these kind of phase three trials. So I think they are going to become more and more widespread. And they are very unlikely to be a passing fad. And as we all know, we do live in this kind of abysogenic environment and obesity has just risen and risen over the last few decades. I think, though, the kind of message remains that they're not magic fixed. They are powerful drugs. You still do need to make those lifestyle changes alongside them. The concerning side of it, of course, there's so many positive benefits. And I reiterate

where Ella said, I've also seen people have wonderful results in the clinic and personally. But Georgie's got a really good question. And she said, if you're not overweight, is it bad for you? For example, if you just wanted to do it for four weeks or if you're considered a healthy body size in shape and you just wanted to drop a little bit of weight because that's what we're seeing a lot of in the media. And I think this is where we have to be so careful because these are not cosmetic drugs. They're not aesthetic drugs. These are medications designed for people living with obesity or overweight with obesity related diseases. They haven't really been studied in kind of

populations of people who are of a healthy BMI. And I think this is where we do have to be so careful because they're not medications that you can really take for a few weeks or get beach body ready or kind of ready for that wedding. I think we still do have to approach them very carefully. And we don't know what the kind of the risk to reward it becomes more difficult, especially when you have a healthy BMI. It's really interesting. who talk about that because that is what we have seen so many questions on. I think because there has been in the press quite a lot of positive things, obviously these drugs are being so heavily researched at the moment where, you know, there's things coming out saying to your point, it changes

the food noise, but people wanting to drink less and potentially being interesting for addictive behavior, for some anti-inflammatory benefits, potentially some cancer protective benefits. And as a result, they're getting this, it feels like sometimes in the media, this halo effect of actually should everybody, no matter what their BMI be on that, should be on them. So someone else has said BMI is normal, but have a huge amount, huge, huge amount of food noise. That was, that was not me. They said lots of hugers and really battle to stay this weight. Can I get it? Should I get it? Yeah, I think once again, with people of a healthy BMI, there are potential risks and there's all these other risks of, so you have these gastrointestinal risks. You do have nausea, vomiting, diarrhea,

constipation. You do have some more serious risks like pancreatitis, gallstones, bowel blockages. And then you also have these more long-term consequences, which I think are important to consider. So muscle loss, and I'm sure you guys have talked about this a lot, is that kind of malnutrition side of things, because, you know, we're already not necessarily eating enough fiber. and all these important healthy fats and polyphenols and fruits of veg. So it could restrict that further. And I think the final thing to say is if you have a kind of past history of any eating disorders, especially restrictive eating disorders, I do have says that it could exacerbate them.

I'm so glad you brought that up because I think the psychological impact as well is absolutely massive. And if you don't have the right support network around you, This is obviously for people, because people can get this on the black market, Jack. You know, we know this is happening. We can't deny that there doesn't seem to be a cutoff criteria if you pay privately to be able to get hold of one. So there's lots of different factors to really take into account. And I do question. I don't think people are being screened that way before they take these medications.

And the question from Nat that I have next for you really leads on to the main concern. That's a reason why a lot of people are not opting for. it perhaps, which is what do you know are the long-term side effects of this drug? So we do have, we've got 20 years of these medications being around and being used for type two diabetes. What we don't necessarily know is the weight loss doses are often much higher than what has been used for diabetes. And we've also got this new generation of weight loss medication. It's a new generation of the gLP ones. That's like I say, a Zempic and Majaro, and there's more coming. And these lead to significantly higher body weight loss than

the old generation. And like I say, when your appetite is being restricted that much more, we don't really know the full long-term consequences, how some of that kind of subclinical micronutri deficiencies could play on, how things like the muscle loss could play out. And I think the other thing to think about with this is most people on these medications are not getting anywhere near the level of support we're seeing in the study. So like you say, it's kind of like the wild west of online pharmacies. So even if you are getting the right medication, most of these pharmacies are not providing nutritional advice at all really. And I think the kind of aim with a lot of these online pharmacy is just to get out as much medication as high dose as possible

without considering the kind of wraparound support. I was really struck actually speaking to someone I know who's who's on them at the moment. And when he started them, it was through a big online pharmacy and they say, do you think you need to go up a dose? He was like, I don't know. You know, it's really interesting. These are obviously powerful drugs and they're kind of being put out to laymen, to the point of like just general public, people with no medical knowledge whatsoever to say, like, do you think you should increase your dose? Do you need to increase your dose? Yeah, all online, just the kind of online questionnaire, which I was so surprised about. But we mentioned a minute ago about the pros, that, you know, the positives of these drugs that have been, as I said, quite widely reported.

And I think what's creating quite a lot of the confusion to my mind in terms of people with a healthier BMI or wanting to lose three or four kilos sort of thing, wondering if they should take them. Because, as I said, they're sort of, you know, conferences and studies coming out saying, oh, actually it could be positive for cancer prevention, anti-inflammatory. Lenny's asked for that, what are the pros as well of these drugs, particularly regarding inflammation? Are we seeing some interesting new developments there that we weren't expecting outside of the weight loss? So there definitely are some fascinating studies looking into this. And especially, I think the inflammation side of things is particularly interesting. What we are seeing in the studies, like you say, we are seeing this reduction in all sorts of things, from heart disease, type 2 diabetes, stroke, obstructive sleep apnea, polycytic ovary syndrome,

all of these things. And like you say, cancer and even dementia too. What we haven't quite kind of teased out is whether there is this independent GOP1 effect on this or whether a huge amount of that is actually just improving your metabolic health and reducing obesity. Because we know, a lot of the initial fat you actually lose when you lose weight can be visceral fat. And that's the fat that's metabolically active that can cause a lot of this smouldering inflammation in the first place. So I suspect a lot of the effect is just due to weight loss and improve metabolic health. There may be a small independent effect, but I think it is possibly too early to stay for sure. And we still, again, a lot of this is studied in people living with obesity

and is not studied in people of a healthy BMI. I think that's the really key thing to reiterate, isn't it? Because it's the fact that these drugs are appealing to everybody. That is really it. And like Ella said, I think we get very excited. I mean, if this could help cure or cancer, it's such a huge sweeping statement to make. We have seen media outlets jump on that. We've seen these stories come out.

And a story, not a story, a question I've got from Ali. It's almost like a little anecdote. Ali said, thanks for talking about GLP1. As a personal trainer, this is something my clients bring up all the time. I think it's great for those who have a lot of excess fat. And what I've noticed, though, is that clients who are only slightly overweight and wanting to take it to lose six to 10 pounds. I think that the Serena Williams advert hasn't helped.

Can you also discuss what happens when people try to come off GLP1? So most people plan to, will this be the next yo-yo diet on and off meds for life? Which I thought, what a good question. Yeah, now that's a great question. So just kind of tackling the bit about the yo-yo diet and that weight meat gain. So we do know with these medications, so they reduce your appetite and they reduce that food noise. And I kind of think of them as these noise-canceling headphones that you can go about your day. You can ignore that pesky food noise.

once you tape them off, that food noise does return with a vengeance. And we're seeing in the studies that two-thirds of the weight you initially lost is regained within the first year, and actually by 20 months, all the weight is really regained. At least that's what we see in the studies. And that weight regain is actually quite significantly higher than if you go, even on what you describe as maybe a more conventional diet. So there is this concern that, especially if you don't change your eating habits and you don't do all these extra lifestyle interventions whilst you're on the medications. And if you're not using them as maybe a way to embrace these healthy eating habits, then I think that's when, yeah, the weight regain is a concern.

We had so many questions on that. I can't kind of list them all out because there were so many, but all of these saying, I think it's everybody. wanting to get to the root of is this a miracle, honestly? Because as I said, there were so many people saying, well, can I take it and then will I regain the way? Because I do think they're being given this kind of halo to some extent, which was why I was curious about your viewpoint at the beginning of like, will this be the new normal? Because I think they're touted as this idea that kind of it's the next frontier, like actually in future, will all be taking them. And someone had asked in particular, like, what are the benefits of microdosing?

Because I think there is some suggestion, certainly I feel from things that I read, that these are so powerful, actually, should everybody to be taking them, should everybody be microdosing on them? Yeah, well, I think with the microdosing avenue, like I said, we still don't know whether the inflammation is actually just because you're improving the root cause of many of these problems, which often is obesity and eating potentially too many processed junk foods as well. So we don't know whether there are these independent effects. And even back to the cancer thing, with obesity, obesity increases risk of 13 different

cancers. So there's all these upstream effects of what obesity of the problems obesity can cause. So it will be interesting to see if they do do studies into people of a healthy BMI, but I think I'm a bit skeptical for now because, again, we kind of talked about some of these addiction issues. It does actually seem to reduce your, for instance, your alcohol consumption, but only if you are living with obesity. And I think if you are giving it to someone who is healthy BMI who might even be malnourished because they drink too much alcohol, then the risks rapidly increase or further malnourishment. It raises the question. I know, we find in the Retrition Clinic is, you know, weight loss is never a linear line. It's very

rarely a linear line. I think that's what most people, when they go on these drugs, they're like, wow, you know, it's just been a, there's no plateau. I'm just losing and I'm losing. And weight loss requires psychology and it requires nutritional intervention. Like you said, most people are going to be deficient in fibre, their gut microbiome is going to be impacted, their nutrient absorption. And I think a lot of people are now also releasing books on GLP-1s. things are popping up everywhere before we have the research, which has another thing to question, you know, completely with nutrition. But Lizzie's asked such a good question. She said, are there natural alternatives? Because are there foods that act like GLP1s?

So it's a really interesting question. And so there are certain foods may slightly increase your GLP1 more than others. But the important thing to remember here is that there's so many other gut hormones involved in appetite. And GLP1 is just one of dozens and dozens of gut hormones, including important hormones like ghrelin and leptin are particularly important in appetite. So what is happening when you take the GOP ones, you're giving this incredibly much higher dose of GLP1 in your bloodstream. And the other important thing is that it's not broken down rapidly. So when you get this natural occurring GLP1, it's broken down within, two minutes really. So I, when there's a lot of stuff saying, oh, this will naturally increase your

GLP ones, again, I would be a bit skeptical of that. So I would be, I would be careful, especially when there's supplements and products that are promoting a natural GLP one, I would beware, especially on social media. It's funny that you said that because we had another question for Martina literally saying that are natural GLP1 supplements available, that are available on the market a good substitute or are they a money grab? I would say a money grab almost certainly. These medications have been carefully designed to not be degraded by the body and keep that really high level of GDP1. So often actually the levels are more than 10 times higher than your body would be producing. So that's another thing to consider.

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Close the garage door? Yep. Installed window sensors, smoke sensors, and H-Rexam. cameras with night vision. No. And you set up credit card transaction alerts, a secure VPN for a private connection, and continuous monitoring for our personal info on the dark web. I'm looking into it. Stress less about security. Choose security solutions from TELUS for peace mind at home and online. Visit tellus.com slash total security to learn more. Conditions apply. I know in your book you talk about food noise. I think it's just first of all important for our

listeners to touch on why we're in this predicament. So it's really really, hard to lose weight, living in an obesitygenic environment. Can you just touch and explain briefly to everybody why you felt compelled to write about it, first of all, and what the major challenges are, because a lot of the questions we've also had are

I'm experiencing this. A lot of people saying, I can't get rid of the food noise. Yeah, so I really wrote this book because it is the wild west out there of online pharmacy prescribing, really. And I think people are just not providing that extra support, they're not provided that the risks and rewards of these medications, the side effects and how to manage them. And I think with all that in mind, if you don't have

that kind of extra advice guidance, then you're probably going to lose less fat, more muscle. You may have some degree of malnutrition. And then it'll also be more difficult to keep that weight off for the long term. So I think the book really is, and I've got 50 nutritious recipes written by my mum, who has written many successful health books, Claire Bailey Mosley, just to provide all the right nutrients you need and encourage you to retain that muscle. So I think it's just so important to provide that kind of wrap around information. So would you say food noise then it's definitely just it's marketing everywhere, it's advertising, it's the lack of information,

is it social media, there must be so many facets to it. Yeah, so food noise itself is a turn that was basically popularised because of the weight loss medications. And yeah, it's your cravings, it's that constant mental chatter around food. And I think the interesting thing with food noise is the volume is likely turned up a lot higher for some people than others. So for some people, it may just be that urge to go out and grab that sugary, salty snack. But for others, some people do wake up thinking about food.

They're often planning their next meal, even when they're currently eating. And I think all of this is so exacerbated by, well, firstly, things like our stressful lives, but also you kind of, you mentioned that food environment. We live in this food environment where these addictive foods are everywhere. and they are designed to be overeaten and the kind of slight sound as smell is designed to attract us so often our best intentions

can be derailed by that food noise and by the food environment we live in. Do you think there's enough conversation when we're looking at GLP ones and all these drugs around the kind of irony here that we have created to your point this, I mean it's a deeply capitalist problem but that we've created this food environment

that we now have to medicate our way out of because, you know, it's really interesting. I went to the supermarket yesterday. It's my daughter's birthday. Yesterday we're having a birthday party on Saturday. I went to buy some stuff for the birthday party. It was just had breakfast. It was 9 o'clock in the morning.

Like, all was good. And suddenly I find myself in like the sweet aisle. And you're like, oh, I can eat a bit of this. I can eat a bit of that. And you just, I didn't even want it. But suddenly you're there and you are surrounded by, you know, bright packaging and all the rest of it. And you're like, and we have that all the time.

And it's so difficult to consistently say, no, thank you. I don't know. I feel quite strongly that we're not talking about the kind of insanity of the situation where, you know, there is a conversation or well, maybe everyone will be on these drugs. Maybe, you know, people of a healthy weight will be microdosing and everyone of a slightly overweight or obese will be on these drugs in the kind of fuller sense of the drug. And we'll all be on it forever. and that will be how we cure food noise.

And then you hear that some manufacturers are trying to manufacture products that get around the GLP ones and still make you want to eat more food and you just sort of have to step back and think like, this is a dystopia, isn't it? I completely agree. I think Big Pharma is trying to solve a problem created

by Big Food ultimately. And we do live in this situation where for many decades, these big food companies have, just been allowed to run rampant. Many people consider some of these big food confectionery companies are almost the new big tobacco and they've used a similar playbook. So we do live in this situation where these medications are effective at reducing that food noise at kind of providing what some people class is like a sticking plaster, but it's not solving many of the root cause

issues. And I think the only real way to tackle some of that is realistically some degree of regulation. And I think people are making steps in that direction, which is great to see. Yeah, it is very dystopia. I think we live in such a strange place where if you really strip it back to basis, we've got more access to food than ever before. And it's just caused so much ill health, essentially. And of course, we've got to look at ultra-process foods here. We've got to the types of foods, like you said, hyper-palatable options that are being produced and marketed everywhere. And Jack, can I just ask what your opinion is on the changing landscape? So I saw, for instance, the other day on quite a well-known podcast, two girls on a TV show openly discussing

the fact that they went from, you know, a size 10 to a size 6 or a size 12 to a size 8. You know, healthy sizes essentially for women. And they said, well, it's because I've been using a Zen pic. And they're very open about it, but what kind of message? I mean, Ella, the messaging around it is big. Yeah, I think, Jack, we've talked a lot this year and it started back in kind of January, February time, where it was award season and you had your, you know, the Oscars and all the rest of it. And there was quite a lot of commentary on the kind of return of size zero, the celebrity landscape. And, you know, the return of the lollipop body where your head is, you know, the top of the lollipop and your body's because your body is so small. And I think something

really and I have just consistently noticed in the show and our community and the headlines that we've been picking up, there's this increasing pressure again outside of these drugs for people from a health perspective when we're talking about, you know, obese, a BMI and health conditions associated when we're looking at actually just particularly the female body, I think unfortunately in this case. And the insecurities it's creating and people starting to use it just solely for aesthetics. I think we're both quite nervous about the pressure that that's putting on people. What do your take on that landscape and do you think it's shifting? This is probably one of my biggest concerns with the GLP ones, is that unfortunately there is a

loss of stigma around weight, which is often exacerbated by the media, really. And this is where things do become quite dangerous because when people who are taking them who are maybe of a healthy BMI or what's kind of described as a normal BMI between 18 and 25, then I think we have to be very, very careful because these sorts of weights may become the new norm. If someone of a normal BMI is taking these medications and then someone who's not taking the medications, they see their friends taking them, then it could be that they are encouraged. to take them themselves. I think this is really quite a concerning thing. And this is where I think more regulation definitely needs to be in place. So at the very least, there should be an initial

video consultation or in person where you can really prove your BMI, your weight. And do you think we're going to see that regulation? Do you think that people behind the scenes are really working and foresee this being a concern? I really hope so. And unfortunately, these things do take time for whatever reasons, especially because these medications are relatively new. They've kind of, at this weight loss dose, they've really been around since around 2021. And I really hope they do make these changes because it would be quite concerning if a lot of people who are of a kind of healthy body weight are then taking these medications to reduce even further. Yeah, we did have a few questions on things like that.

We had one there, didn't you, on some eating disorders? So this is quite, well, it's a natural question here. And I think there's a lot of ethics behind this question. I'll let you deal with it, Jack, when it comes. So Charlotte has said, has there been any research into using GLP-1s to treat binge-eating disorders or any other eating disorders? So with binge eating disorders, there has been some small, randomized controlled trials. and most of these are with some of the previous generations so that they are a little less effective like lyra glutide and they do seem to slightly reduce that binge eating pattern and I think

mechanistically it probably does make sense that they they could be effective because part of some of the issues in binge eating is that sudden urge to eat those hiker palatable foods like you say, and then you get into these vicious cycles often where you succumb to that food noise and then you may end up binge eating and then you feel terrible about yourself. And then that can actually lead to further binge eating. So there are some trials actually underway at the moment in the next generation of GLP1 weight loss medications. So things like Minjaro that are underway, but we don't know yet how effective they are. But it's definitely interesting to keep an eye on. It is interesting because you just think it's kind of chicken and egg,

but I think a lot of people in my clinic that work with eating disorders would argue, well then you're just putting a plaster over it again by looking at a medication for a binge eating disorder rather the dealing with why you're binging in the first place. So I think it's definitely a space to watch. Ella, we've got, have we got one more there that we can ask Jack? We have. And do you know what? I think it's such a great place actually to wrap it up. and maybe I could add on to this question, which is, what do you wish everyone knew about these drugs? And I wonder, Jack, if there were like three to five things.

Because as I said, they're given this kind of, as everything is, in a clickpatey landscape, a kind of devil or like miracle angle, I think most of the time, you know, dystopian world, this is big pharma gone mad, or like, these are a miracle, everyone will be on them, ASAP. what do you think everyone actually needs to know about these drugs? Yeah, I'll just go through a few then. So firstly, that these weight loss medications can be really effective for people

who have really struggled with their weight, and they have tried all these diet options first. If they're living with obesity and obesity-related diseases, then these medications can help some people, but they're not a magic fix at the end of the day. And tied to that is you still do need to, so secondly, you do need to make those nutritional changes. For me, the Mediterranean-style diet is the most evidence-based diet in the world and is pat full of plenty of protein, healthy fats, fiber, all the nutrients you really need. And it has been linked to incredibly good health outcomes as well in reducing heart disease, dementia, all sorts of things.

thirdly these medications in the trials you can you see 25 to 40% of the way you lose is is muscle so eating enough protein and doing those some of those strength training exercises when you're on these weight loss medications is actually really important and I think finally if if you don't make those sustainable healthy eating habits lifestyle changes and learn to eat to live differently then it is very likely that you will regain that weight. So if you are, and I'm very much not encouraging people to take them and I'm not saying, don't take them. If you feel like it is right for you,

then you still need to make those sustainable eating habits in a way that lasts a lifetime, really. Jack, thank you so much. I think it's very important to summarise. So essentially they can't negate the benefits of living and breathing a healthy lifestyle. that still has to happen alongside taking these medications. And what I've concluded from what you've said today

is we just don't have the research on a healthy BMI yet. It really is concretely based on those that are categorized above the amount that we would classify to be healthy. And it's really watched this space because it does look like we're going to just hear more and more from people with GLP-1s, I think, and more emerging. Without a doubt, and I think with me, more emerging and the more widespread availability and those costs coming down that we need to be

we need to approach it with more care and knowledge than ever i think and they really you know they could change how we act in society as a whole it's um there a breakthrough medication but one that needs to be approached in the right way that's a really really helpful summary jack thank you so much for joining us and taking everyone's questions thank you guys so much for listening as always keep sending your questions in i definitely think we're going to you to do a part two of this in six to 12 months when we start getting more information through because yes you said this is definitely an evolving topic but anything else you want us to talk about send us your questions on the apple podcast comments and reviews on spotify or you can always

email them to me ella at deliciousiello.com otherwise have a lovely day and jack thank you so much again for joining us thank you so much for having me now i've had a great time Thank you.