Best Friends with Nicole Byer and Sasheer Zamata

Gayle & Oprah. Bonnie & Clyde. Nicole & Sasheer. Enter the pantheon of best friendship. When you’re forced to change your number, are sick of being single, or want to take a pole-dancing class, you’re going to need a best friend...and if you don’t, you can still have this podcast.

153 episodes transcribed
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Comedy

Nicole Hates Mondays

Episode Date: May 20, 2026

What do hundreds of Garfield-themed phones washed ashore and a robbery of 12 tons of Kit Kats have in common? Nicole and Sasheer talk about b...

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Comedy

Nicole Has A Nut Stash

Episode Date: May 13, 2026

This episode, Nicole and Sasheer leave no conversational stone unturned, covering everything from falling in love with chatbots to Baby’...

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Comedy

Sasheer is a Daring Soul

Episode Date: February 18, 2026

Nicole and Sasheer have so much to dish about this week, covering everything from the Black Eyed Peas and Vanilla Ice's decision making...

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Comedy

Nicole Phones a Friend

Episode Date: February 11, 2026

This week on Best Friends, Nicole and Sasheer are locked in and ready to learn about everything from glittery lotion to snowboarding uphill....

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Comedy

Sasheer Has 20/20 Vision

Episode Date: February 4, 2026

This week, Nicole and Sasheer chat about Waymos (aka Vin Voms), reminisce about visiting a dangerous waterfall, practice eye strengthening ex...

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Comedy

Nicole's Newly Into Tron

Episode Date: January 28, 2026

This week, Nicole and Sasheer take a trip down memory lane all the way back to Nicole's middle school cafeteria. Sasheer also shares her exci...