Best Friends with Nicole Byer and Sasheer Zamata

Gayle & Oprah. Bonnie & Clyde. Nicole & Sasheer. Enter the pantheon of best friendship. When you’re forced to change your number, are sick of being single, or want to take a pole-dancing class, you’re going to need a best friend...and if you don’t, you can still have this podcast.

140 episodes transcribed
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Comedy

Sasheer is a Daring Soul

Episode Date: February 18, 2026

Nicole and Sasheer have so much to dish about this week, covering everything from the Black Eyed Peas and Vanilla Ice's decision making...

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Comedy

Nicole Phones a Friend

Episode Date: February 11, 2026

This week on Best Friends, Nicole and Sasheer are locked in and ready to learn about everything from glittery lotion to snowboarding uphill....

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Comedy

Sasheer Has 20/20 Vision

Episode Date: February 4, 2026

This week, Nicole and Sasheer chat about Waymos (aka Vin Voms), reminisce about visiting a dangerous waterfall, practice eye strengthening ex...

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Comedy

Nicole's Newly Into Tron

Episode Date: January 28, 2026

This week, Nicole and Sasheer take a trip down memory lane all the way back to Nicole's middle school cafeteria. Sasheer also shares her exci...

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Comedy

Nicole Knows Her Cars

Episode Date: November 19, 2025

Nicole and Sasheer are back with a special solo episode for your video watching eyes and podcast listening ears! They get into Nicole's lates...

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Comedy

Nicole's In Her Pants Era

Episode Date: November 5, 2025

Nicole and Sasheer are back in the studio to debrief Sasheer’s house project, uncover the origin story of cereal mascots, try a new...

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Comedy

Nicole's Fruit Journey

Episode Date: October 22, 2025

Nicole and Sasheer are back from a quick trip to Vegas and ready to break down all of their funniest moments, from seeing Ashlee Simpson to t...